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The role of tau kinases in Alzheimer's disease

published in: Current Opinion in Drug Discovery and Development

date of publication: 2010-09-01

main subject: Alzheimer's disease

Cites articles 108

Date

Title

Authors

2010-03-31

Caspase activation precedes and leads to tangles

Tara L Spires-Jones, Bradley Hyman, Rose Pitstick, George Carlson, Brian J Bacskai, Alix de Calignon, Leora M Fox
2010-01-01

Tau phosphorylated at tyrosine 394 is found in Alzheimer's disease tangles and can be a product of the Abl-related kinase, Arg.
2010-04-13

The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons
2010-04-01

A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo

Kazuhiro Ito, William L. Klein
2010-03-30

Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice

Tsuneya Ikezu
2010-03-06

Glycogen synthase kinase-3beta and the p25 activator of cyclin dependent kinase 5 increase pausing of mitochondria in neurons

Jean-Pierre Brion
2010-02-27

Drosophila models of human tauopathies indicate that Tau protein toxicity in vivo is mediated by soluble cytosolic phosphorylated forms of the protein

Magalie Lecourtois, Dominique Campion
2009-11-19

Experimental diabetes mellitus exacerbates tau pathology in a transgenic mouse model of Alzheimer's disease

Lars M. Ittner, Jürgen Götz, Fabien Delerue, Yazi D Ke
2009-11-19

Amyloid-beta42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism

Scott Ryan, David S Park, Daniel Figeys
2009-10-16

Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain

Daniel Vogt
2009-10-08

Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer's disease

Inge Grundke-Iqbal, Cheng-Xin Gong
2009-08-22

c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice

Enrique M Toledo, Rommy von Bernhardi
2009-07-01

Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin

Sally A Frautschy, Harry V Vinters
2009-06-02

Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease

Lars M. Ittner, Jürgen Götz, Yazi D Ke
2009-05-01

Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects

Tomas L Falzone, Concepción Lillo
2009-01-30

Mechanisms of tau-induced neurodegeneration

Inge Grundke-Iqbal, Cheng-Xin Gong
2009-02-01

The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity

Irina Gaisina
2009-10-01

Conformational changes specific for pseudophosphorylation at serine 262 selectively impair binding of tau to microtubules

Markus Zweckstetter, Eckhard Mandelkow, Martin Blackledge
2009-08-05

Altered phosphorylation but no neurodegeneration in a mouse model of tau hyperphosphorylation.

Thomas Fath, Jürgen Götz, Jakob von Engelhardt, Lars Lewejohann
2009-11-06

Neurodegeneration in an Abeta-induced model of Alzheimer's disease: the role of Cdk5

João P Lopes, Catarina R. Oliveira, Paula M. Agostinho
2008-12-01

Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.

Tsuneya Ikezu, Pawel Ciborowski
2008-12-01

Tau oligomerization: a role for tau aggregation intermediates linked to neurodegeneration
2008-10-29

Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity
2008-10-17

Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model

Tzu-Kang Sang
2008-09-26

Structure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau Dephosphorylation

Yigong Shi
2008-10-02

Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia

Lars M. Ittner, Thomas Fath, Jürgen Götz, Janet van Eersel, Yazi D Ke
2008-08-01

Cytosolic abnormally hyperphosphorylated tau but not paired helical filaments sequester normal MAPs and inhibit microtubule assembly

Inge Grundke-Iqbal
2008-08

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

Yuan He, Matthew S Macauley, David J Vocadlo, Keith A. Stubbs, Gideon Davies
2008

Role of axonal transport in neurodegenerative diseases

Andrew Grierson, Kurt J De Vos, S. Ackerley, Christopher C. Miller
2008-05-14

Novel genetic tools reveal Cdk5's major role in Golgi fragmentation in Alzheimer's disease
2008-05-08

A review of islet of Langerhans degeneration in rodent models of type 2 diabetes
2008-01-01

"JIP"ing along the axon: the complex roles of JIPs in axonal transport

Sandhya P Koushika

Article - wd:Q34138413

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