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Targeting TORC2 in multiple myeloma with a new mTOR kinase inhibitor.

author

Patrick Frost

Joseph Gera

published in: Blood

date of publication: 2010-08-04

language: English

main subject: multiple myeloma

Cites articles 35

Date

Title

Authors

2010-01-13

Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor

Marina Konopleva
2009-05-14

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

David M. Sabatini, Nathanael Gray
2009-03-03

Phase II trial of temsirolimus in patients with relapsed or refractory multiple myeloma
2009-02-10

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

Robbie Loewith, Zachary A Knight
2009-01-01

Regulation of D-cyclin translation inhibition in myeloma cells treated with mammalian target of rapamycin inhibitors: rationale for combined treatment with extracellular signal-regulated kinase inhibitors and rapamycin

Patrick Frost, Joseph Gera
2009-04-21

The pharmacology of mTOR inhibition.

David M. Sabatini
2009-02-24

TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2.

Gerard Manning
2008-09

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

Antonella Papa
2008-07-17

Combined functional and molecular analysis of tumor cell signaling defines 2 distinct myeloma subgroups: Akt-dependent and Akt-independent multiple myeloma

Hans-Konrad Müller-Hermelink, Hermann Einsele
2008-06-05

Clinical and biological significance of RAS mutations in multiple myeloma

S. Vincent Rajkumar, Rafael Fonseca
2008-05-30

Dexamethasone-induced apoptotic mechanisms in myeloma cells investigated by analysis of mutant glucocorticoid receptors
2008-05-16

Wnt signaling inhibits Forkhead box O3a-induced transcription and apoptosis through up-regulation of serum- and glucocorticoid-inducible kinase 1.
2008-12-01

mTORC2 is the hydrophobic motif kinase for SGK1.

Virginie Mieulet
2008-06-01

Involvement of hepcidin in the anemia of multiple myeloma

Tomas Ganz
2006-04-06

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

David M. Sabatini
2005-10-01

Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/phosphatidylinositol 3-kinase cascade

Patrick Frost
2005-08-19

Analysis of PTEN deletions and mutations in multiple myeloma
2005-02-01

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

David M. Sabatini
2005-02-03

Regulation of cap-dependent translation by eIF4E inhibitory proteins
2005-10-11

mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes
2004-12-01

Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3

James T. Murray, Rudi Marquez, Dietmar Kuhl
2004-08-19

Combination of the mTOR inhibitor rapamycin and CC-5013 has synergistic activity in multiple myeloma

Paul G. Richardson, Kenneth C. Anderson, Joseph H Antin, Shaji K Kumar, Nikhil V Munshi, Noopur Raje, Dharminder Chauhan, Kenji Ishitsuka, Teru Hideshima, Klaus Podar, Steven Le Gouill, Constantine S Mitsiades
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Upstream and downstream of mTOR

Nahum Sonenberg
2004-08-10

In vivo antitumor effects of the mTOR inhibitor CCI-779 against human multiple myeloma cells in a xenograft model

Patrick Frost
2004-07-27

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

Hediye Erdjument-Bromage, Paul Tempst, Do-Hyung Kim, David M. Sabatini
2004-01-01

mTOR as a target for cancer therapy

Shile Huang
2004-01-01

Raptor and mTOR: subunits of a nutrient-sensitive complex,Raptor and mTOR: Subunits of a Nutrient-Sensitive Complex
2003-12-24

Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone

Anna Dimberg
2003-09-01

Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling

C. Ronald Kahn, Paul G. Richardson, Kenneth C. Anderson, Nikhil V Munshi, Dharminder Chauhan, Teru Hideshima, Klaus Podar, Constantine S Mitsiades, Laurence P Catley, Nicholas S Mitsiades, Masaharu Akiyama, Reshma Shringarpure
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Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779
2001-11-01

Hierarchical phosphorylation of the translation inhibitor 4E-BP1

Anne-Claude Gingras, Stephen K Burley
2001-11-01

The AKT kinase is activated in multiple myeloma tumor cells

Article - wd:Q34374071

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