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Dysregulation of the TSC-mTOR pathway in human disease

published in: Nature Genetics

date of publication: 2005-01-01

language: English

Cites articles 92

Date

Title

Authors

2004-07-27

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

Hediye Erdjument-Bromage, Paul Tempst, Do-Hyung Kim, David M. Sabatini
2004-04-01

eIF4E--from translation to transformation

Nahum Sonenberg
2004-01

mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E

Andrew R. Tee
2004-07-01

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

Nabeel Bardeesy, Ronald A. DePinho
2004-07

The LKB1 tumor suppressor negatively regulates mTOR signaling

Nabeel Bardeesy, Lewis C. Cantley, Ronald A. DePinho
2004-03-09

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

Nabeel Bardeesy, Rebecca L Hurley, Lewis C. Cantley, Ronald A. DePinho
2004-04-01

Autophagy as a cell death and tumor suppressor mechanism

Devrim Gözüaçık, Adi Kimchi
2004-06

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Cahir J O'Kane, Douglas F. Easton
2004-05-23

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways.

Massimo Loda, Todd Golub, Judith Manola
2004-07-01

De novo germline mutation in the serine-threonine kinase STK11/LKB1 gene associated with Peutz-Jeghers syndrome
2004-05-01

Ras is involved in the negative control of autophagy through the class I PI3-kinase
2004-01-01

Roles of phosphatidylinositol 3'-kinase and mammalian target of rapamycin/p70 ribosomal protein S6 kinase in K-Ras-mediated transformation of intestinal epithelial cells

B Mark Evers
2004-04-02

Tuberous sclerosis complex 2 gene product interacts with human SMAD proteins. A molecular link of two tumor suppressor pathways

Francis W. Ruscetti, Daniel C Bertolette
2004-09-19

BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling

Leanne Wiedemann, Linheng Li
2004-05-01

Searching for the hereditary causes of renal-cell carcinoma
2004-02-09

A germ-line insertion in the Birt-Hogg-Dubé (BHD) gene gives rise to the Nihon rat model of inherited renal cancer
2004-07-19

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
2004-09-01

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
2004-08-11

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

M Joaquin, George Thomas
2004-05-24

Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte

Christopher G. Proud
2004-05

The TOR pathway: a target for cancer therapy
2003-02-01

Tor signalling in bugs, brain and brawn

Estela Jacinto
2003-06-01

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
2003-06-01

Rheb promotes cell growth as a component of the insulin/TOR signalling network
2003-06

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
2003-06

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
2003-08-01

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
2003-11-26

TSC2 mediates cellular energy response to control cell growth and survival
2003

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

Jérôme Boudeau, Dario Alessi
2003-07-22

Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases
2003-11-01

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

Fiona C Leiper, Dietbert Neumann, Uwe Schlattner, Theo Wallimann, David Carling
2003-04-01

Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma

Article - wd:Q34380413

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