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Acetylcholine receptor (AChR) α5 subunit variant associated with risk for nicotine dependence and lung cancer reduces (α4β2)₂α5 AChR function

published in: Molecular Pharmacology

date of publication: 2010-09-29

main subject: nicotine, nicotine dependence, lung cancer

Cites articles 36

Date

Title

Authors

2010-07-01

The nicotinic acetylcholine receptor alpha5 subunit plays a key role in attention circuitry and accuracy

Craig D C Bailey, Evelyn K. Lambe
2010-04-16

Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice
2010-01-01

On the origin of ion selectivity in the Cys-loop receptor family
2009-08-20

Mouse striatal dopamine nerve terminals express alpha4alpha5beta2 and two stoichiometric forms of alpha4beta2*-nicotinic acetylcholine receptors
2009-05-14

Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.

Carlos Cruchaga, Richard A. Grucza, Alison Goate, John P Budde, Laura J. Bierut, Victoria L. Stevens, Nancy L Saccone, Sarah Bertelsen, Louis Fox, Oliver Reyes, Jerry Stitzel, Noah Spiegel, Weimin Duan, Joe Henry Steinbach
2009-05-01

Phasic acetylcholine release and the volume transmission hypothesis: time to move on

William Howe
2009-03-01

Nicotinic receptors in the habenulo-interpeduncular system are necessary for nicotine withdrawal in mice

Renea Sturm
2009-06-01

Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes

Jerry Stitzel, Richard A. Grucza, Alison Goate, Pamela A F Madden, Laura J. Bierut, Arpana Agrawal, Dorothy Hatsukami, Naomi Breslau, Nancy L Saccone, Michele L Pergadia, Gary E Swan, Weimin Duan, Eric O Johnson
2009-01-12

Acetylcholine-stimulated [3H]GABA release from mouse brain synaptosomes is modulated by alpha4beta2 and alpha4alpha5beta2 nicotinic receptor subtypes
2009-08-12

John Daly's compound, epibatidine, facilitates identification of nicotinic receptor subtypes
2008-11-19

Crucial role of alpha4 and alpha6 nicotinic acetylcholine receptor subunits from ventral tegmental area in systemic nicotine self-administration

Jean-Pierre Changeux
2008-09-12

Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site
2008-07-11

A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction

William M. McMahon
2008-06-02

Variants in nicotinic receptors and risk for nicotine dependence

Tatiana Foroud, Victor Hesselbrock, Bernice Porjesz, Marc A. Schuckit, William J Horton, Jerry Stitzel, Richard A. Grucza, John I. Nurnberger, Jay A. Tischfield, Howard J Edenberg, Alison Goate, Samuel Kuperman, John P Budde, Pamela A F Madden, Danielle M. Dick, Xiaoling Xuei, Dorothy Hatsukami, C. Robert Cloninger, Naomi Breslau, Ovide F. Pomerleau, John R Kramer, Nancy L Saccone, Sarah Bertelsen, Louis Fox, Laura Jean Bierut, Oliver Reyes, Gary E Swan, Eric O Johnson
2008-04-01

A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

Thorgeir E. Thorgeirsson, Frank Geller, Jon T Bergthorsson, Gyda Bjornsdottir, Halla Skuladottir, Gregory T. Jones, Laura Asin, Berta Sáez Gutiérrez, Roberto Pola, Lambertus Kiemeney, Augustine Kong, Tómas Gudbjartsson, Jeffrey Gulcher, Julius Gudmundsson, Katja K H Aben
2008-04-03

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

Vladimír Bencko, Kristian Hveem, Dimitris Trichopoulos, Lars Vatten, Hans Einar Krokan, Franco Merletti, David Zaridze, Vladimír Janout, Eleonóra Fabiánová, Neonila Szeszenia-Dabrowska, Peter Rudnai, Wolfgang Ahrens, Elio Riboli, Frank Skorpen, Mark Lathrop, Paolo Boffetta, Antonio Agudo, Pierre Hainaut, Valerie Gaborieau, Jolanta Lissowska, Paolo Vineis, Diana Zelenika, John K. Field, Eiliv Lund, Joseph K. McLaughlin, Steven A. Narod, Jakob Linseisen, Bas Bueno-de-Mesquita, Simone Benhamou, Ivana Holcátová, Kristina Kjaerheim, Lorenzo Simonato, Claire M. Healy
2008-05-01

Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1

Peter Broderick, Jian Gu, Gordon B. Mills
2008-04-01

Roles of accessory subunits in alpha4beta2(*) nicotinic receptors
2008-03-26

Structural mechanisms underlying benzodiazepine modulation of the GABA(A) receptor
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Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking

Vincent Mooser, Federica Tozzi, Clyde Francks
2007-07-14

Allosteric modulation of nicotinic acetylcholine receptors.
2007-06-02

Heterogeneity and complexity of native brain nicotinic receptors

Michele Zoli
2007-06-15

Galanthamine and Non-competitive Inhibitor Binding to ACh-binding Protein: Evidence for a Binding Site on Non-α-subunit Interfaces of Heteromeric Neuronal Nicotinic Receptors
2007-10-24

The alpha4beta2alpha5 nicotinic cholinergic receptor in rat brain is resistant to up-regulation by nicotine in vivo
2007-06-15

Nicotinic alpha5 subunit deletion locally reduces high-affinity agonist activation without altering nicotinic receptor numbers.
2006-01-03

Common determinants of single channel conductance within the large cytoplasmic loop of 5-hydroxytryptamine type 3 and alpha4beta2 nicotinic acetylcholine receptors

Tim Hales, Jane E Carland
2006-11-28

Ca2+ permeability of the (alpha4)3(beta2)2 stoichiometry greatly exceeds that of (alpha4)2(beta2)3 human acetylcholine receptors.
2005-09-23

Nicotine acts as a pharmacological chaperone to up-regulate human alpha4beta2 acetylcholine receptors
2005-04-01

A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization
2003-10-01

Human alpha4beta2 acetylcholine receptors formed from linked subunits
2003-03-20

Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors
2002-06-01

First and second transmembrane segments of alpha3, alpha4, beta2, and beta4 nicotinic acetylcholine receptor subunits influence the efficacy and potency of nicotine

Article - wd:Q34458445

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