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Stability of p53 homologs

author

Dmitry B Veprintsev

Alan Fersht

1943 -

published in: PLOS One

date of publication: 2012-10-24

language: English

Cites articles 44

Date

Title

Authors

2012-08-06

Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition

Alan Fersht
2012-08-06

First-order rate-determining aggregation mechanism of p53 and its implications

Alan Fersht
2012-06-19

Mutant p53 aggregates into prion-like amyloid oligomers and fibrils: implications for cancer

Carlos H.I. Ramos, Ana Carolina Stumbo, Yraima Cordeiro, Jerson Lima, Guilherme A P de Oliveira
2011-06-10

Interaction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 Tetramer

Alan Fersht, Andreas C Joerger, Nina Morgner, Kevin Pagel, Carol V. Robinson
2010-02-10

The tumor suppressor p53: from structures to drug discovery

Alan Fersht, Andreas C Joerger
2010-05-19

p63 and p73, the ancestors of p53.

Daniel Coutandin, Volker Dötsch
2009-12-23

Conservation of DNA-binding specificity and oligomerisation properties within the p53 family

Andreas C Joerger, Dmitry B Veprintsev
2009-09-16

Stability effects of mutations and protein evolvability
2009-08-13

Adaptive evolution of p53 thermodynamic stability

Alan Fersht
2009-07-01

Cognate DNA stabilizes the tumor suppressor p53 and prevents misfolding and aggregation.

Yraima Cordeiro, Jerson Lima
2008-07-29

Targeted rescue of a destabilized mutant of p53 by an in silico screened drug

Alan Fersht, Andreas C Joerger, Frank M. Boeckler, Dmitry B Veprintsev
2008-01-01

Structural biology of the tumor suppressor p53.

Alan Fersht, Andreas C Joerger
2008-02-09

The p73 DNA binding domain displays enhanced stability relative to its homologue, the tumor suppressor p53, and exhibits cooperative DNA binding.

Franca Fraternali
2008-04-30

Application of high-throughput isothermal denaturation to assess protein stability and screen for ligands
2008-01-30

Algorithm for prediction of tumour suppressor p53 affinity for binding sites in DNA.

Dmitry B Veprintsev, Alan Fersht
2006-10-11

Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination

Aled Edwards, Oleg Fedorov, Cheryl Arrowsmith, Gregory A Wasney
2006-10-02

Structural basis for understanding oncogenic p53 mutations and designing rescue drugs

Alan Fersht, Andreas C Joerger
2006-02-06

Core domain interactions in full-length p53 in solution

Alan Fersht, Dmitry B Veprintsev
2006-06-05

Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains.

Alan Fersht, Andreas C Joerger
2005-09-01

Missense meanderings in sequence space: a biophysical view of protein evolution

Daniel Hartl
2004-11-01

Adaptation of enzymes to temperature: searching for basic "strategies".

George N. Somero
2004-07-01

p63 and p73: roles in development and tumor formation
2004-01-09

Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations

Alan Fersht, Andreas C Joerger
2003-08-01

Fibrillar aggregates of the tumor suppressor p53 core domain

Yraima Cordeiro, Jerson Lima, Leonardo R Andrade, Débora Foguel
2003-04-16

Kinetic Instability of p53 Core Domain Mutants

Alan Fersht, Lars O. Hansson, Dmitry B Veprintsev
2002-08

Live or let die: the cell's response to p53
2002-02-01

Determination of ligand-MurB interactions by isothermal denaturation: application as a secondary assay to complement high throughput screening
2002-03-01

A virtual tour of the Guide for zebrafish users
2001-10-01

Rescuing the function of mutant p53.

Alan Fersht
2001-12

High-density miniaturized thermal shift assays as a general strategy for drug discovery
2001-07-26

High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53.
2001-05-01

The ligand affinity of proteins measured by isothermal denaturation kinetics

Article - wd:Q34462386

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