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A pilot trial of the microtubule-interacting peptide (NAP) in mice overexpressing alpha-synuclein shows improvement in motor function and reduction of alpha-synuclein inclusions

author

Marie-Françoise Chesselet

published in: Molecular and Cellular Neuroscience

date of publication: 2010-12-27

main subject: overexpression, Synuclein

Cites articles 40

Date

Title

Authors

2009-12

Genome-wide association study reveals genetic risk underlying Parkinson's disease

Christian Gieger, Thomas Illig, Henry Houlden, Sampath Arepalli, Peter Lichtner, Daniela Berg, Rejko Krüger, Günther Deuschl, Katrina Gwinn, Delia Lorenz, Michael Steffens, Sonja Scholz, Claudia Schulte, Jose Bras, Honglei Chen, Yikyung Park, Michael S. Okun, Alison Goate, Stephen Chanock, Thomas Gasser, Kelly D Foote, Christine Klein, John Anthony Hardy, Hubert H Fernandez, Mark R Cookson, Joel S Perlmutter, Xuemei Huang, Andrew Singleton, Coro Paisán-Ruíz, Arthur Schatzkin, Olaf Riess, Bryan Traynor, Manu Sharma, Dena G. Hernandez, Stefan Schreiber, Javier Simón Sánchez, J Raphael Gibbs, Michael Marmot, Albert R Hollenbeck
2009-10-01

Addressing Alzheimer's disease tangles: from NAP to AL-108.
2009-03-12

Microtubule depolymerization suppresses alpha-synuclein accumulation in a mouse model of multiple system atrophy

Yasuyo Suzuki
2009

alpha-Synuclein and neuronal cell death

Mark R Cookson
2009-03-02

NAP protects memory, increases soluble tau and reduces tau hyperphosphorylation in a tauopathy model

Yan Jouroukhin
2008-11-06

Genomewide association study for susceptibility genes contributing to familial Parkinson disease

Tatiana Foroud, Nathan Pankratz, Jeanne C Latourelle, Anita L DeStefano, Richard H Myers, James F. Gusella, Francis Walker, Cheryl A. Halter, Kimberly Doheny, Jemma B Wilk, PSG-PROGENI and GenePD Investigators, Coordinators and Molecular Genetic Laboratories
2008-07-01

Olfactory deficits in mice overexpressing human wildtype alpha-synuclein

Eliezer Masliah, Sheila M Fleming, Nicole A Tetreault, Caitlin K Mulligan, Ché B Hutson, Marie-Françoise Chesselet
2008-05-01

Abnormal colonic motility in mice overexpressing human wild-type alpha-synuclein

Yvette Taché, Marie-Françoise Chesselet
2008-02-01

Association of olfactory dysfunction with risk for future Parkinson's disease

Lenore J Launer, Caroline M Tanner, Lon R. White, Kamal H Masaki, Helen Petrovitch
2008-01-16

A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease

Yan Jouroukhin, Rebekah Feng, Ottavio Arancio
2007-01-01

Olfaction in Parkinson's disease

Richard Doty
2007-12-01

Behavioral and histopathological consequences of paraquat intoxication in mice: effects of alpha-synuclein over-expression
2007-01-04

Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra

Tom N Grammatopoulos, David G. Standaert, Bradley Hyman
2007-12-01

NAP, a neuroprotective drug candidate in clinical trials, stimulates microtubule assembly in the living cell
2007-11-20

Impairment of microtubule system increases alpha-synuclein aggregation and toxicity.
2007-08-24

Activity-dependent neuroprotective protein snippet NAP reduces tau hyperphosphorylation and enhances learning in a novel transgenic mouse model.

Albert Pinhasov
2007-01-01

Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage

Mark Mattson
2006-12-01

Impairment of microtubule-dependent trafficking by overexpression of alpha-synuclein
2006-08-23

Behavioral effects of dopaminergic agonists in transgenic mice overexpressing human wildtype alpha-synuclein

Eliezer Masliah
2006-08-01

Peptide neuroprotection through specific interaction with brain tubulin
2006-07-21

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

Susan Lindquist, Aaron D Gitler, Nancy M. Bonini
2005-01-01

NAP: research and development of a peptide derived from activity-dependent neuroprotective protein (ADNP)

Paul S. Aisen
2005-01-01

Activity-dependent neurotrophic factor-9 and NAP promote neurite outgrowth in rat hippocampal and cortical cultures
2004-12-01

The femtomolar-acting NAP interacts with microtubules: Novel aspects of astrocyte protection
2004-10-01

Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein

Pierre-Olivier Fernagut, Eliezer Masliah
2004-05-01

Intranasal administration of NAP, a neuroprotective peptide, decreases anxiety-like behavior in aging mice in the elevated plus maze.

Roy N Alcalay
2004-04-29

A femtomolar acting octapeptide interacts with tubulin and protects astrocytes against zinc intoxication
2003-09-01

The neuroprotective peptide NAP inhibits the aggregation of the beta-amyloid peptide
2003-02-24

Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease

Corinna Burger, Anders Björklund
2003

Staging of brain pathology related to sporadic Parkinson's disease
2002-08-01

NAP accelerates the performance of normal rats in the water maze

Albert Pinhasov, Roy N Alcalay
2002-06-01

Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters

Edward Rockenstein, Eliezer Masliah

Article - wd:Q34612993

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