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Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.

pengarang

Thomas Moore-Morris

1981 -

Matthew Stroud

1950 -

Emily R Pfeiffer

diterbitkan dalam: PLOS Genetics

tanggal publikasi: 2014-02-20

subyek utama: Biomekanika, Kardiomiopati

Cites articles 58

Date

Judul

Pengarang

2013-02-19

Myopathic lamin mutations impair nuclear stability in cells and tissue and disrupt nucleo-cytoskeletal coupling

Lori L Wallrath
2013-01-25

The LINC complex is essential for hearing

Lilach M Friedman, Henning F Horn, Kyle J Roux, Karen Avraham, Amiel Dror, Kuan-Teh Jeang
2012-09-04

Structural insights into SUN-KASH complexes across the nuclear envelope

Zhubing Shi
2012-07-01

Mechanosensitive mechanisms in transcriptional regulation

Donald E. Ingber
2012-05-25

LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins

Ulrike Kutay
2012-05-01

LINC complex alterations in DMD and EDMD/CMT fibroblasts

Sabu Abraham, Iakowos Karakesisoglou
2012-02-03

Thymosin beta 4 is dispensable for murine cardiac development and function

Stephan Lange
2011-11-01

Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders

Kris Noel Dahl
2011-11-14

Nuclear lamins and laminopathies
2011-11

Nesprin-3 regulates endothelial cell morphology, perinuclear cytoskeletal architecture, and flow-induced polarization

Emily R Pfeiffer
2010-12-01

Myocardial lineage development
2010-04-10

Nuclear morphology and deformation in engineered cardiac myocytes and tissues
2010-05-01

The genetics of dilated cardiomyopathy
2010-02-01

Diseases of the nuclear envelope
2010-02-01

Matrix elasticity, cytoskeletal forces and physics of the nucleus: how deeply do cells 'feel' outside and in?
2009-11-24

Nesprin-1 mutations in human and murine cardiomyopathy
2009-10-28

Nesprin 1 is critical for nuclear positioning and anchorage
2009-08-17

Bringing KASH under the SUN: the many faces of nucleo-cytoskeletal connections
2009-08-03

Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality

Hongqiang Cheng
2009-07-07

Obscurin determines the architecture of the longitudinal sarcoplasmic reticulum

Stephan Lange, Gretchen A Meyer, Hongqiang Cheng
2009-02-20

IL-6 loss causes ventricular dysfunction, fibrosis, reduced capillary density, and dramatically alters the cell populations of the developing and adult heart
2009-02-19

Identification of potential pharmacological targets by analysis of the comprehensive G protein-coupled receptor repertoire in the four cardiac chambers

Thomas Moore-Morris, Matteo E. Mangoni, Laurent Journot, Christelle Dantec, Joel Nargeot
2008-12-01

Patterns of evolutionary conservation in the nesprin genes highlight probable functionally important protein domains and isoforms

Roland G. Roberts
2008-11-13

Disruption of nesprin-1 produces an Emery Dreifuss muscular dystrophy-like phenotype in mice

Yuan Zhang, James M Holaska
2008-09-12

Dysfunctional connections between the nucleus and the actin and microtubule networks in laminopathic models

Christopher M Hale, Denis Wirtz
2008-06-01

Nuclear shape, mechanics, and mechanotransduction
2008-03-12

Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness

Christopher M Hale, Denis Wirtz
2007-08-29

Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity

Roland G. Roberts
2007-07-13

Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration

Jerry Ssu-Hsien Lee, Christopher M Hale, Denis Wirtz
2007-01-31

Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation

Xiaochang Zhang
2007-06-29

Determination of cell types and numbers during cardiac development in the neonatal and adult rat and mouse
2006-09-01

Effects of static and cyclic loading in regulating extracellular matrix synthesis by cardiovascular cells

Jane Grande-Allen

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