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Inverse agonism gains weight

author

Roger A H Adan

published in: Trends in Pharmacological Sciences

date of publication: 2003-06-01

Cites articles 40

Date

Title

Authors

2003-02-01

Agouti-related protein prevents self-starvation.
2003-01-01

Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations

Philippe Froguel, Christian Vaisse
2003-03-01

Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms

Giles See How Yeo, Sadaf Farooqi, Stephen O'Rahilly, Julia M. Keogh, Emma J Lank, Benjamin G Challis
2002-02-01

Mechanisms of inverse agonism at G-protein-coupled receptors
2002-09-01

A polymorphism in the human agouti-related protein is associated with late-onset obesity

Treva K. Rice, Claude Bouchard, Tuomo Rankinen, Michael A Province
2002-10-01

Lessons from constitutively active mutants of G protein-coupled receptors

Pierre Corvol, Stéphanie Miserey-Lenkei, Charles Parnot
2002-06-01

Sustained orexigenic effect of Agouti related protein may be not mediated by the melanocortin 4 receptor
2001-01-01

AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor
2001-05-01

Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor
2001-04-01

Effects of leptin and corticosterone on the expression of corticotropin-releasing hormone, agouti-related protein, and proopiomelanocortin in the brain of ob/ob mouse
2001-05-01

Time course of short-term and long-term orexigenic effects of Agouti-related protein (86-132).
2001-05-01

Association between an agouti-related protein gene polymorphism and anorexia nervosa

Johannes Hebebrand, Helmut Remschmidt, Stephanie H M van Goozen
2001-09-01

A role for the Agouti-Related Protein promoter in obesity and type 2 diabetes.

Mark D. Shriver
2001-02-01

Antagonist and agonist activities of the mouse agouti protein fragment (91-131) at the melanocortin-1 receptor
2001-01-01

Constitutive signaling of the human cytomegalovirus-encoded chemokine receptor US28.
2000-04-06

Central nervous system control of food intake
2000-12-01

High constitutive activity of native H3 receptors regulates histamine neurons in brain

Xavier Ligneau
2000-02-01

alpha-Melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression
2000-07-01

Long-term orexigenic effects of AgRP-(83---132) involve mechanisms other than melanocortin receptor blockade

Randy J. Seeley
2000-12-01

Tonic inhibition of food intake during inactive phase is reversed by the injection of the melanocortin receptor antagonist into the paraventricular nucleus of the hypothalamus and central amygdala of the rat.

Helgi B. Schiöth
2000-03-01

Inverse agonism at heptahelical receptors: concept, experimental approach and therapeutic potential
2000-05-01

Inverse agonism at G protein-coupled receptors: (patho)physiological relevance and implications for drug discovery

Adriaan P IJzerman
1999-09-01

Anatomy of an endogenous antagonist: relationship between Agouti-related protein and proopiomelanocortin in brain
1999-02-01

Altered energy balance causes selective changes in melanocortin-4(MC4-R), but not melanocortin-3 (MC3-R), receptors in specific hypothalamic regions: further evidence that activation of MC4-R is a physiological inhibitor of feeding.
1999-04-01

Several Mutations in the Melanocortin-4 Receptor Gene Including a Nonsense and a Frameshift Mutation Associated with Dominantly Inherited Obesity in Humans
1999-01-01

Agonists and inverse agonists for the herpesvirus 8-encoded constitutively active seven-transmembrane oncogene product, ORF-74

Mette M. Rosenkilde, Hans Bräuner-Osborne, Thue W Schwartz
1999-09-01

Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
1998-06-01

Constitutive activation of opsin by mutation of methionine 257 on transmembrane helix 6

Thomas P Sakmar
1998-07-01

Human interferon-gamma-inducible protein 10 (IP-10) inhibits constitutive signaling of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor
1998-02-01

Interaction of Agouti protein with the melanocortin 1 receptor in vitro and in vivo
1997-10-03

Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
1997-03-01

Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice

Article - wd:Q35161587

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