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An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor β (RARβ, NR1B2) Selective Agonist.

författare

Vanessa Delfosse

1982 -

Hinrich Gronemeyer

1951 -

William Bourguet

Pierre Germain

Valérie Vivat

Catherine Teyssier

publicerad i: PLOS ONE

utgivningsår: 2015-05-01

språk: engelska

huvudämne: tretinoin

Refererar artiklar 41

Datum

Titel

Författare

2014-03-19

Dual RXR Agonists and RAR Antagonists Based on the Stilbene Retinoid Scaffold

Claudio Martínez, Hinrich Gronemeyer, Angel R de Lera
2013-11-22

Functions, therapeutic applications, and synthesis of retinoids and carotenoids

Hinrich Gronemeyer, Belen Vaz
2012-03-06

Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors

Dino Moras, Natacha Rochel
2012-01-01

Retinoid receptors and therapeutic applications of RAR/RXR modulators

William Bourguet, Hinrich Gronemeyer, Angel R de Lera
2011-04

Overview of the CCP4 suite and current developments

Paul Emsley, Kevin Cowtan, Randy Read, Keith S Wilson, Airlie McCoy, Harold R Powell
2010-12-27

Stromal retinoic acid receptor beta promotes mammary gland tumorigenesis

Vincent Giguère
2010-07

A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor

William Bourguet, Catherine A. Royer, Hinrich Gronemeyer, Angel R de Lera, Pierre Germain
2010-02

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Nathaniel Echols, Jane Shelby Richardson, David C. Richardson, Li-Wei Hung, Paul D. Adams, Thomas C. Terwilliger, Randy Read, Ralf W Grosse-Kunstleve, Pavel V Afonine, Vincent B Chen, Jeffrey J Headd, Gary J Kapral, Nigel W Moriarty, Gábor Bunkóczi, Airlie McCoy, Peter H. Zwart
2010-02

Integration, scaling, space-group assignment and post-refinement
2009-05-01

Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists

William Bourguet, Hinrich Gronemeyer, Vivian Pogenberg, Catherine A. Royer, Pierre Germain
2009-10-01

C3 halogen and c8'' substituents on stilbene arotinoids modulate retinoic Acid receptor subtype function

Angel R de Lera, Hinrich Gronemeyer, Claudio Martínez, Pierre Germain
2009-05-08

Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs).
2007-02-22

Structure, function and modulation of retinoic acid receptor beta, a tumor suppressor

Hinrich Gronemeyer, Angel R de Lera, Pierre Germain
2006-12

International Union of Pharmacology. LX. Retinoic acid receptors

Pierre Chambon, Reuben Lotan, Ronald M. Evans, Angel R de Lera, Hinrich Gronemeyer, Pierre Germain
2006-01-01

Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis

Pierre Chambon, Norbert B Ghyselinck
2006-12

Overview of nomenclature of nuclear receptors

Bart Staels, Michael Spedding
2005-09-01

Synthetic retinoids: recent developments concerning structure and clinical utility

Hiroyuki Kagechika
2004-12

Coot: model-building tools for molecular graphics

Paul Emsley, Kevin Cowtan
2004-09-01

Rational design of RAR-selective ligands revealed by RARbeta crystal structure

Natacha Rochel, Hinrich Gronemeyer, Angel R de Lera, Pierre Germain
2004-05-01

Synthetic retinoids and their nuclear receptors
2004-11-04

Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies

Hinrich Gronemeyer, Catherine A. Royer, William Bourguet, Vivian Pogenberg, Angel R de Lera, Pierre Germain
2002-01-01

Retinoids and their receptors in cancer development and chemoprevention

Reuben Lotan
2002-07-01

Retinoids in combination therapies for the treatment of cancer: mechanisms and perspectives
2002-05-01

Endogenous reactivation of the RARbeta2 tumor suppressor gene epigenetically silenced in breast cancer

Nicoletta Sacchi
2002-01-01

Co-regulator recruitment and the mechanism of retinoic acid receptor synergy

Hinrich Gronemeyer, Pierre Germain
2001-12-01

The promise of retinoids to fight against cancer

Hinrich Gronemeyer
2001-04-01

Epigenetic downregulation of the retinoic acid receptor-beta2 gene in breast cancer

Martin Widschwendter
2000-09-08

Structural basis for isotype selectivity of the human retinoic acid nuclear receptor
2000-02

Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains

Pierre Chambon, Hinrich Gronemeyer
1999-09-01

The targeted disruption of both alleles of RARbeta(2) in F9 cells results in the loss of retinoic acid-associated growth arrest.
1999-08

Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists

Pierre Chambon, Hinrich Gronemeyer
1999-05-01

Identification of a novel class of retinoic acid receptor beta-selective retinoid antagonists and their inhibitory effects on AP-1 activity and retinoic acid-induced apoptosis in human breast cancer cells

Hiroyuki Kagechika

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