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The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia

författare

Vahram Haroutunian

publicerad i: Alzheimer's & Dementia

utgivningsår: 2014-12-09

huvudämne: Alzheimers sjukdom, protein tyrosine kinase binding, demens

Refererar artiklar 49

Datum

Titel

Författare

2014-07-01

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

José Luis Molinuevo, Marco Colonna, Christine Van Broeckhoven, Julie van der Zee, Kristel Sleegers, Christian Haass, Sebastiaan Engelborghs, Marc Suárez-Calvet, Asli Demirtas-Tatlidede, Daniel A. Alcolea, Alfredo Ramirez, Henrik Zetterberg, John Hardy, Gernot Kleinberger, Tony Wyss-Coray, Alberto Lleó, Raquel Sanchez-Valle, Anna Antonell, Michael T Heneka, Nadine Pettkus, Sabina Tahirovic, Sven Lammich, Jean-Jacques Martin, Fargol Mazaheri, Elise Cuyvers
2014-03-24

Evidence of trem2 variant associated with triple risk of Alzheimer's disease

Faisal A Al-Allaf
2013-11-20

Investigation of triggering receptor expressed on myeloid cells 2 variant in the Wisconsin Registry for Alzheimer's Prevention
2013-10-16

Heterozygous TREM2 mutations in frontotemporal dementia

Irene Piaceri, Cristian Bonvicini, Massimo Gennarelli, Daniela Galimberti, Benedetta Nacmias, Sandro Sorbi, Elio Scarpini, Barbara Borroni, Chiara Fenoglio, Silvia Bagnoli, Silvana Archetti, Cinzia Barone, Marinella Turla
2013

Inflammatory process in Alzheimer's Disease
2013-07-12

Assessment of TREM2 rs75932628 association with Alzheimer's disease in a population-based sample: the Cache County Study

Mark Ebbert
2013-06-21

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease

Dennis W. Dickson, Nilüfer Ertekin-Taner, Sruti Rayaprolu, Elizabeth Finger, Charles L White, Maria Barcikowska, Catherine Lomen-Hoerth, Ryan J Uitti, Zbigniew K Wszolek, Rosa Rademakers, Ronald C. Petersen, Bruce L. Miller, Owen A. Ross, William Seeley, David S Knopman, Bradley F Boeve, Grzegorz Opala, Anna Krygowska-Wajs, James F Meschia, Neill R Graff-Radford, Keith A Josephs, Kevin B Boylan, Matt Baker, Carol F Lippa, Eileen H Bigio, Bianca Mullen, Kimmo Hatanpaa, Magdalena Boczarska-Jedynak, Timothy Lynch
2013-04-01

Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease

Vilmundur Gudnason, Christine Suver, Radu Dobrin, Liviu-Gabriel Bodea, Harald Neumann, David A Bennett, Tammy Gillis, Marcy E. MacDonald, Eric E Schadt
2013-04-09

Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease

Eric M. Reiman, Kenneth S. Kosik
2013-04-04

GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease

Margaret Pericak-Vance, Matthew Bailey, Celeste M Karch, Bruno A Benitez, Denise Harold, Carlos Cruchaga, Alison Goate, Lindsay A. Farrer, John Q. Trojanowski, David M. Holtzman, Sheng Chih Jin, Richard Mayeux, Alzheimer's Disease Neuroimaging Initiative, David A Bennett, John C. Morris, Anne M Fagan, Jonathan L Haines, Philip L De Jager, Leslie M. Shaw, John S. K. Kauwe, Joshua M Shulman, D Galasko, Oscar Harari, Yefei Cai, David S Carrell, Sarah Bertelsen, Lori B Chibnik, Vivianna M Van Deerlin, Elaine Peskind, Alzheimer Disease Genetic Consortium (ADGC), Gerard D Schellenberg, Amy Gerrish, Tara Skorupa, GERAD Consortium, Virginia Man-Yee Lee, Amanda T Jeng
2013-02-14

TREM2 in Alzheimer's disease

Jin-Tai Yu, Lan Tan, Teng Jiang
2013-02-05

TREM2 is associated with the risk of Alzheimer's disease in Spanish population

Bruno A Benitez, Carlos Cruchaga, Pau Pastor
2013-01-03

Attenuated inflammatory response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice following stroke

Bettina Linnartz-Gerlach, Harald Neumann
2013-01-10

Variant of TREM2 associated with the risk of Alzheimer's disease

Kári Stefánsson, Knut Engedal, Dan Rujescu, Augustine Kong, Hreinn Stefansson, Unnur Thorsteinsdottir, Cornelia M. van Duijn, Albert Hofman, Ingileif Jonsdottir, M. Arfan Ikram, Ole A. Andreassen, Srdjan Djurovic, Carla Ibrahim-Verbaas, Harald Hampel, Ina Giegling, James J Lah, Stacy Steinberg, Jon Snaedal, Johanna Huttenlocher, Thorlakur Jonsson, Allan Levey, Ingun D. Ulstein
2013-10-01

TREM2 and neurodegenerative disease

Paul M. Thompson, Derrek P Hibar
2013-10-09

Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia.

Rik Vandenberghe, Sebastiaan Engelborghs, Christine Van Broeckhoven, Julie van der Zee, Peter Paul De Deyn, Marc Cruts, Maria Mattheijssens, Patrick Cras, Tim Van Langenhove, Stéphanie Philtjens, Mathieu Vandenbulcke, Githa Maes, Karolien Bettens, Nathalie Geerts, Elise Cuyvers, Jasper Van Dongen, Kristel Sleegers, Ilse Gijselinck, BELNEU consortium
2013-09-13

Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia.

Pau Pastor, Jordi Pérez-Tur, Jordi Clarimón, Agustín Ruíz, Oriol Dols Icardo, Maria Jesus Bullido Gomez-Heras, Adolfo López de Munain, Anna Antonell, Ana Frank García, Cristina Razquin, Raquel Sanchez-Valle, Eliecer Coto
2013-05-21

Alzheimer's disease risk alleles in TREM2 illuminate innate immunity in Alzheimer's disease
2013-01-01

Microglia: scapegoat, saboteur, or something else?

Adriano Aguzzi, Mariko L Bennett, Ben Barres
2013-01-10

TREM2 variants in Alzheimer's disease

Andrew Singleton, Julie Williams, John Hardy, Jean-Charles Lambert, Ekaterina Rogaeva, Peter Henry St George-Hyslop, Philippe Amouyel, Carlos Cruchaga, Jose Bras, Kevin Morgan, Alison Goate, Rita Guerreiro, Rosa Rademakers, Tammaryn Lashley, Minerva M Carrasquillo, Elisa Majounie, Celeste Sassi, John Collinge, Steven G. Younkin
2012-11-07

Convergent findings for abnormalities of the NF-κB signaling pathway in schizophrenia

Vahram Haroutunian, Larry J. Siever
2012-07-11

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

Kári Stefánsson, Augustine Kong, Hreinn Stefansson, Unnur Thorsteinsdottir, Aarno Palotie, Patrick Sulem, Tushar Bhangale, Gyda Bjornsdottir, Daníel F. Guðbjartsson, Erik G Jönsson, Ole A. Andreassen, Stacy Steinberg, Jon Snaedal, Johanna Huttenlocher, Thorlakur Jonsson
2012-03-13

Insights into the regulation of protein abundance from proteomic and transcriptomic analyses

Christine Vogel, Edward Marcotte
2012-12-01

A system-level transcriptomic analysis of schizophrenia using postmortem brain tissue samples.

Larry J. Siever
2012-01-01

Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature

Tony Wyss-Coray
2011-12-12

TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells
2011-09-05

Molecular and genetic evidence for abnormalities in the nodes of Ranvier in schizophrenia

Jigar Jogia, Stella Giakoumaki, David Collier
2010-07-12

Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease

Benoit Melchior, Bor-Kai Hsiung, Harald Neumann, Matthias Staufenbiel
2009-10-29

Gain in brain immunity in the oldest-old differentiates cognitively normal from demented individuals

Vahram Haroutunian
2009-03-19

A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

Midori A Yenari
2008-07-24

Origin and physiological roles of inflammation
2008-10-01

TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice

Michael Walter

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