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Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex

författare

Rudolph E. Tanzi

1958 -

publicerad i: Journal of Neuroscience

utgivningsår: 2010-09-01

språk: engelska

huvudämne: Alzheimers sjukdom

Refererar artiklar 33

Datum

Titel

Författare

2011-01-01

SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk

Margaret Pericak-Vance, Joseph H. Lee, Peter Henry St George-Hyslop, Lindsay A. Farrer, Richard Mayeux, Christiane Reitz, Ekaterina Rogaeva, Jonathan L Haines, András Palotás, Lorraine Clark, Jean Paul G Vonsattel, Lili-Naz Hazrati, Shinya Tokuhiro
2010-01-01

Amyloid-beta oligomers: possible roles as key neurotoxins in Alzheimer's Disease
2010-02

A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose

Jennifer Elizabeth Below, Dan L. Nicolae, John M. Lachin, Andrew D. Paterson, Nancy J Cox
2009-03-01

Genomic convergence to identify candidate genes for Alzheimer disease on chromosome 10.

Margaret Pericak-Vance, Jonathan L Haines, Stephan Züchner, Harry E. Gwirtsman
2008-11-01

Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's disease

Olav M. Andersen, Thomas E Willnow
2008-05-20

Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation

Karen Duff, Ottavio Arancio, Barry Ganetzky
2008-02-27

Different motifs regulate trafficking of SorCS1 isoforms.

Morten S Nielsen, Anders Nykjaer, Dietmar Kuhl, Guido Hermey
2007-09-12

SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1

Olav M. Andersen, Thomas E Willnow
2007-12-01

Neuronal LR11/sorLA expression is reduced in mild cognitive impairment

Elliott J Mufson, Sue Leurgans
2007-07-23

Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA.

Oddmund Bakke, Guido Hermey, Peder Madsen
2007-02

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

Ekaterina Rogaeva, Peter Henry St George-Hyslop, Gerold Schmitt-Ulms, Olav M. Andersen, Rivka Inzelberg, Thomas E Willnow, Clinton Baldwin, Joseph H. Lee, Kathryn L. Lunetta, Sandro Sorbi, Lindsay A. Farrer, Dennis W. Dickson, Robert C. Green, Richard Mayeux, Toshitaka Kawarai, Ronald C. Petersen, L. Adrienne Cupples, Neill R Graff-Radford, Amalia Bruni, Innocenzo Rainero, Lorenzo Pinessi, Yosuke Wakutani, Christopher Bohm, Taiichi Katayama, Nobuto Shibata, Ranjan Duara, Fanggeng Zou, Robert P Friedland, You-Qiang Song, Steven G. Younkin
2007-04-10

SORCS1: a novel human type 2 diabetes susceptibility gene suggested by the mouse.

Susanne Clee, Jerome I Rotter, John Blangero, Kent D Taylor, Mark O Goodarzi
2006-10-01

Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis
2006-09-01

LR11/SorLA expression is reduced in sporadic Alzheimer disease but not in familial Alzheimer disease

Thomas J Montine
2006-09-01

High-resolution quantitative trait locus analysis reveals multiple diabetes susceptibility loci mapped to intervals<800 kb in the species-conserved Niddm1i of the GK rat.
2006-06-12

Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates
2006-02-01

The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments
2006-01-11

Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme

Ithan D. Peltan, Olav M. Andersen, Thomas E Willnow
2006-05-07

Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus.

Susanne Clee, Philipp W Raess
2006-02-01

Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11.

Olav M. Andersen, Michael W Parker, Roberto Cappai, William J McKinstry, Thomas E Willnow, Colin L. Masters, Bradley Hyman
2005-12-01

Model-guided microarray implicates the retromer complex in Alzheimer's disease
2005-09-07

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

Tilman Breiderhoff, Olav M. Andersen, Michael Gotthardt, Thomas E Willnow, Anders Nykjaer, Roberto Cappai, Colin L. Masters, Bradley Hyman
2005-05-01

The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease
2004-08

Loss of apolipoprotein E receptor LR11 in Alzheimer disease
2002-12-12

Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells

Guido Hermey, Peder Madsen
2001-01-01

Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease

Karen Ashe
1997-07-01

Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease

Eliezer Masliah
1997-02-01

Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a Caucasian population

Christopher J. Talbot, Alison Goate, John C. Morris
1993-08

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

James F. Gusella
1993-08-13

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

Jonathan L Haines
1993-01-01

Fimbrin localized to an insoluble cytoskeletal fraction is constitutively phosphorylated on its headpiece domain in adherent macrophages
1990-08-01

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation

Paul Greengard, Joseph Buxbaum

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