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Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia

author

Daniel Herranz

Valeria Tosello

José M. Matés

Andrew L. Kung

Stephen Rayport

Carlos Cordon-Cardo

1957 -

published in: Nature Medicine

date of publication: 2015-09-21

language: English

main subject: leukemia, lymphoblastic leukemia

Cites articles 33

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On becoming a T cell, a convergence of factors kick it up a Notch along the way

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2011-07-31

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The molecular determinants of de novo nucleotide biosynthesis in cancer cells
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Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia
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Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

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Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation

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Article - wd:Q36137651

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