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Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activity

författare

Kenneth A. Jacobson

Zhan-Guo Gao

Silvia Paoletta

Dilip K Tosh

Francesca Deflorian

publicerad i: Journal of Medicinal Chemistry

utgivningsår: 2012-09-10

språk: engelska

Refererar artiklar 57

Datum

Titel

Författare

2012-06-11

Truncated Nucleosides as A(3) Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane Substitutions

Kenneth A. Jacobson, Zhan-Guo Gao, Silvia Paoletta, Dilip K Tosh
2012-07-16

Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice

Mark J. Zylka
2012-02-08

Activation of adenosine₁ receptors induces antidepressant-like, anti-impulsive effects on differential reinforcement of low-rate 72-s behavior in rats
2012-02-06

Adenosine and glutamate signaling in neuron-glial interactions: implications in alcoholism and sleep disorders
2012-01

Reorganizing the protein space at the Universal Protein Resource (UniProt)

Elisabet Barrera Casanova, Sebastien Gehant, Baris E Suzek, Reija Hieta, Borisas Bursteinas, Xavier Watkins, Sangya Pundir, Steven Rosanoff, Jerven Bolleman, Ruth Y. Eberhardt, Catherine Rivoire, Emmanuel Boutet, Anne Morgat, Elisabeth Coudert, Klemens Pichler, Benoit Bely, Nikolas Pontikos, Michael Tognolli, Alan Wilter Sousa da Silva, Jules Jacobsen, Lionel Breuza, Ivo Pedruzzi, Chuming Chen, Anne Estreicher, John S Garavelli, Michele Magrane, Sylvain Poux, Cecilia Arighi, Elisabeth Gasteiger, Nicole Redaschi, Leyla Garcia, Hamish McWilliam, Raja Mazumder, Alan J Bridge, Rachael Huntley, Claire O'Donovan, Ioannis Xenarios, Maria-Jesus Martin, Rodrigo López, Sandra Orchard, Rolf Apweiler, Ursula Hinz
2012-02-01

Neurabin scaffolding of adenosine receptor and RGS4 regulates anti-seizure effect of endogenous adenosine

Paul Greengard, Kai Jiao
2012-04-30

Finding the sweet spot: the role of nature and nurture in medicinal chemistry

Gyorgy M Keseru
2011-11-12

Partial adenosine A1 receptor agonists for cardiovascular therapies
2011-01-01

Adenosine A(1) receptors in the central nervous system: their functions in health and disease, and possible elucidation by PET imaging
2011-08-01

Truncated (N)-Methanocarba Nucleosides as A(1) Adenosine Receptor Agonists and Partial Agonists: Overcoming Lack of a Recognition Element

Kenneth A. Jacobson, Zhan-Guo Gao, Dilip K Tosh, Francesca Deflorian
2011-06-23

Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

Tony Warne, Christopher G. Tate, Christopher J Langmead
2011-03-10

Structure of an agonist-bound human A2A adenosine receptor

Vsevolod Katritch, Vadim Cherezov, Huixian Wu, Kenneth A. Jacobson, Zhan-Guo Gao, Raymond C Stevens, Gye Won Han
2011-02-08

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors--an update

Christa E Müller, Adriaan P IJzerman, Kenneth A. Jacobson
2011-05

Recent developments in adenosine receptor ligands and their potential as novel drugs
2010-09-01

Discovery of New Human A(2A) Adenosine Receptor Agonists: Design, Synthesis, and Binding Mode of Truncated 2-Hexynyl-4'-thioadenosine

Sun Choi, Kenneth A. Jacobson, Zhan-Guo Gao, Lak Shin Jeong, Lena S Yoo, Xiyan Hou, Varughese Alexander, Kyunglim Kim
2010-06-30

Adenosine amine congener mitigates noise-induced cochlear injury

Srdjan M. Vlajkovic, Ann Chi Yan Wong, Gary D. Housley, Peter R. Thorne
2010-10-14

Comparative anticonvulsant efficacy in the corneal kindled mouse model of partial epilepsy: Correlation with other seizure and epilepsy models
2010-03-03

Adenosine A1 receptors and microglial cells mediate CX3CL1-induced protection of hippocampal neurons against Glu-induced death

Myriam Catalano, Nico van Rooijen, Flavia Trettel
2009-12-01

Functionalized congeners of A3 adenosine receptor-selective nucleosides containing a bicyclo[3.1.0]hexane ring system

Kenneth A. Jacobson, Zhan-Guo Gao, Dilip K Tosh, Moshe Chinn, Athena M Klutz
2008-10-23

Enhanced A3 adenosine receptor selectivity of multivalent nucleoside-dendrimer conjugates

Kenneth A. Jacobson, Zhan-Guo Gao, Athena M Klutz, Asher Shainberg
2008-09-24

Structure-activity relationships of truncated D- and l-4'-thioadenosine derivatives as species-independent A3 adenosine receptor antagonists

Kenneth A. Jacobson, Zhan-Guo Gao, Dilip K Tosh, Lak Shin Jeong, Hyung Ryong Moon, Woo-Hyuk Lee, Athena M Klutz, Xiyan Hou, Seung-Ah Choe
2008-08-07

Selective A(3) adenosine receptor antagonists derived from nucleosides containing a bicyclo[3.1.0]hexane ring system

Sonia de Castro, Kenneth A. Jacobson, Zhan-Guo Gao, Lak Shin Jeong, Jyeshtharaj Joshi, Artem Melman
2008-12-01

A1 adenosine receptor agonists and their potential therapeutic applications
2007-01-01

Discovery of antiepileptic drugs
2006-10-11

N6-Cycloalkyl-2-substituted adenosine derivatives as selective, high affinity adenosine A1 receptor agonists
2006-06-05

Adenosine A1 receptors are crucial in keeping an epileptic focus localized.

Detlev Boison
2006-01-11

Activation of adenosine A1 receptors reduces anxiety-like behavior during acute ethanol withdrawal (hangover) in mice

Rui Daniel Prediger
2004-11-01

2-Substituted adenosine derivatives: affinity and efficacy at four subtypes of human adenosine receptors
2004-01-01

Partial A(1) adenosine receptor agonists from a molecular perspective and their potential use as chronic ventricular rate control agents during atrial fibrillation (AF).
2004-03-25

Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy
2003-11-01

Adenosine receptor agonists: from basic medicinal chemistry to clinical development

Christa E Müller
2003-05-01

N6-Substituted adenosine derivatives: selectivity, efficacy, and species differences at A3 adenosine receptors

Kenneth A. Jacobson

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