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Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells

author

Alessandro Sette

Rama S. Akondy

Bruce D. Walker

Todd M Allen

Rafi Ahmed

1948 -

John Sidney

Zaza M Ndhlovu

Rafick-Pierre Sékaly

Toshiyuki Miura

Filippos Porichis

published in: Journal of Immunology

date of publication: 2013-06-14

language: English

Cites articles 29

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Acquired transcriptional programming in functional and exhausted virus-specific CD8 T cells

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Clonotype and repertoire changes drive the functional improvement of HIV-specific CD8 T cell populations under conditions of limited antigenic stimulation

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Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells

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Rapid demethylation of the IFN-gamma gene occurs in memory but not naive CD8 T cells.

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Article - wd:Q36986131

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