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Widespread AAV1- and AAV2-mediated transgene expression in the nonhuman primate brain: implications for Huntington's disease

författare

John Bringas

Philip Pivirotto

Piotr Hadaczek

publicerad i: Molecular Therapy. Methods & Clinical Development

utgivningsår: 2016-06-29

huvudämne: Huntingtons sjukdom, primate brain

Refererar artiklar 64

Datum

Titel

Författare

2015-09-28

Analytical Ultracentrifugation as an Approach to Characterize Recombinant Adeno-Associated Viral Vectors
2015-04-02

Post-mortem assessment of the short and long-term effects of the trophic factor neurturin in patients with α-synucleinopathies

Charles Warren Olanow
2015-04-01

Transduction of antigen-presenting cells in the brain by AAV9 warrants caution in preclinical studies
2014-10-01

SAFETY AND TOLERABILITY OF MRI-GUIDED INFUSION OF AAV2-hAADC INTO THE MID-BRAIN OF NON-HUMAN PRIMATE.

John Bringas, Piotr Hadaczek
2014-04-28

Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease

Yuqing Li, Jeffrey P. Cantle
2014-05-02

Adeno-associated virus serotypes 1, 8, and 9 share conserved mechanisms for anterograde and retrograde axonal transport

Michael J Castle
2014-03-21

Silencing mutant huntingtin by adeno-associated virus-mediated RNA interference ameliorates disease manifestations in the YAC128 mouse model of Huntington's disease
2014-01-06

Intrajugular vein delivery of AAV9-RNAi prevents neuropathological changes and weight loss in Huntington's disease mice

Brett D Dufour
2014-09-18

Comparative analyses of adeno-associated viral vector serotypes 1, 2, 5, 8 and 9 in marmoset, mouse and macaque cerebral cortex

Masaharu Kinoshita
2013-01-01

Large genetic animal models of Huntington's Disease

Jenny Morton
2013-11-21

AAV9-mediated expression of a non-self protein in nonhuman primate central nervous system triggers widespread neuroinflammation driven by antigen-presenting cell transduction

Philip Pivirotto, Stephen J DeArmond
2013-09-27

Analysis of transduction efficiency, tropism and axonal transport of AAV serotypes 1, 2, 5, 6, 8 and 9 in the mouse brain
2013-09-26

Adeno-associated virus type 6 is retrogradely transported in the non-human primate brain

Lluis Samaranch
2013-07-05

Efficient gene delivery and selective transduction of astrocytes in the mammalian brain using viral vectors

Nicolas Merienne, Gilles Bonvento, Nicole Déglon, Emilie Faivre, Juliette Le Douce
2013-05-02

Strong cortical and spinal cord transduction after AAV7 and AAV9 delivery into the cerebrospinal fluid of nonhuman primates
2013-08-09

Generation and characterization of adeno-associated virus producer cell lines for research and preclinical vector production
2012-08-28

Cerebral infusion of AAV9 vector-encoding non-self proteins can elicit cell-mediated immune responses

Piotr Hadaczek
2012-01-26

Safety and tolerability of magnetic resonance imaging-guided convection-enhanced delivery of AAV2-hAADC with a novel delivery platform in nonhuman primate striatum

John Bringas, Philip Pivirotto
2011-12

Preclinical safety of RNAi-mediated HTT suppression in the rhesus macaque as a potential therapy for Huntington's disease
2011-01-01

Huntington's disease - neuropathology
2011-04-14

Novel platform for MRI-guided convection-enhanced delivery of therapeutics: preclinical validation in nonhuman primate brain
2011-04-12

Preclinical differences of intravascular AAV9 delivery to neurons and glia: a comparative study of adult mice and nonhuman primates
2011-02-22

Interventional MRI-guided putaminal delivery of AAV2-GDNF for a planned clinical trial in Parkinson's disease
2011-10-12

Transduction of striatum and cortex tissues by adeno-associated viral vectors produced by herpes simplex virus- and baculovirus-based methods
2011-07-01

T2 imaging in monitoring of intraparenchymal real-time convection-enhanced delivery

R. Mark Richardson
2011-06-01

Adeno-Associated Virus (AAV) Vectors in the CNS
2010-10-15

Recombinant adeno-associated virus type 2 pseudotypes: comparing safety, specificity, and transduction efficiency in the primate striatum. Laboratory investigation

Kambiz N. Alavian
2010-03-17

Differential vulnerability of neurons in Huntington's disease: the role of cell type-specific features

Jeffrey H Kordower
2010-01

The reward circuit: linking primate anatomy and human imaging
2010-06-08

Eight years of clinical improvement in MPTP-lesioned primates after gene therapy with AAV2-hAADC.

John Bringas, Philip Pivirotto, Piotr Hadaczek
2010-12-25

Design of an in-dwelling cannula for convection-enhanced delivery.

John Bringas
2009-12-15

Comparative transduction efficiency of AAV vector serotypes 1-6 in the substantia nigra and striatum of the primate brain

Csaba Leranth

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