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Targeting PKC: a novel role for beta-catenin in ER stress and apoptotic signaling

author

Kenneth C. Anderson

2000 -

published in: Blood

date of publication: 2008-11-18

language: English

main subject: apoptotic process

Cites articles 62

Date

Title

Authors

2008-07-01

The oral protein-kinase C beta inhibitor enzastaurin (LY317615) suppresses signalling through the AKT pathway, inhibits proliferation and induces apoptosis in multiple myeloma cell lines

Stefano Sacchi, Antonino Neri, Sandra Marmiroli, Lucia Nobili, Jessika Bertacchini, Massimo Federico, Massimo Federico, Anto De Pol
2008-03-01

Enzastaurin, a protein kinase C beta inhibitor, suppresses signaling through the ribosomal S6 kinase and bad pathways and induces apoptosis in human gastric cancer cells

Yung-Jue Bang, Seock-Ah Im, Tae-You Kim, Hwang-Phill Kim, Keun-Wook Lee
2007-12-19

Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo
2007-10-01

The therapeutic role of targeting protein kinase C in solid and hematologic malignancies

Kenneth C. Anderson
2007-06-04

The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress

Paul Dent
2007-04-23

Targeting the beta-catenin/TCF transcriptional complex in the treatment of multiple myeloma

Kumar Sukhdeo, Kenneth C. Anderson
2007-05-24

Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells

Paul Workman
2007-02-01

Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition

Hans-Martin Jäck
2007-11-19

Inhibitors of protein kinase C sensitise multiple myeloma cells to common genotoxic drugs
2007-02-01

Up-regulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma.

Kenneth C. Anderson, Ronald A. DePinho
2007-02-06

Protein kinase C inhibitor enzastaurin induces in vitro and in vivo antitumor activity in Waldenstrom macroglobulinemia

Kenneth C. Anderson, Irene Ghobrial
2006-10-05

Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl).

Kenneth C. Anderson
2006-01-01

Role of the unfolded protein response in cell death
2006-11-01

Protein-kinase-C-mediated beta-catenin phosphorylation negatively regulates the Wnt/beta-catenin pathway
2006-07-01

Enzastaurin (LY317615), a protein kinase Cbeta inhibitor, inhibits the AKT pathway and induces apoptosis in multiple myeloma cell lines
2006-02-28

Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells
2005-10-13

A network-based analysis of systemic inflammation in humans
2005-09-08

Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development

Bradley Spencer-Dene, Abdolrahman Shams Nateri, Axel Behrens
2005

The mammalian unfolded protein response
2005-05-10

Wnts induce migration and invasion of myeloma plasma cells

Ya-Wei Qiang
2005-04-14

Wnt signalling in stem cells and cancer
2005-08-01

The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts.
2005-06-01

Activation of p53-dependent apoptosis by acute ablation of glycogen synthase kinase-3beta in colorectal cancer cells

Dario C Altieri
2004-09-01

Multiple stress signals induce p73beta accumulation
2004-05-01

Beta-catenin simultaneously induces activation of the p53-p21WAF1 pathway and overexpression of cyclin D1 during squamous differentiation of endometrial carcinoma cells

Takeshi Kuwata
2004-04-20

Illegitimate WNT signaling promotes proliferation of multiple myeloma cells

Hans Clevers, Marcel Spaargaren, Henk M. Lokhorst, Andries C. Bloem
2004-10-01

Caveolin-1 is required for vascular endothelial growth factor-triggered multiple myeloma cell migration and is targeted by bortezomib

Paul G. Richardson, Kenneth C. Anderson, Dharminder Chauhan, Kenji Ishitsuka, Teru Hideshima, Klaus Podar, Martin Sattler, Reshma Shringarpure
2004-10-04

Induction of CCAAT/enhancer-binding protein (C/EBP)-homologous protein/growth arrest and DNA damage-inducible protein 153 expression during inhibition of phosphatidylcholine synthesis is mediated via activation of a C/EBP-activating transcription fa
2004-08-09

c-Jun regulates the stability and activity of the p53 homologue, p73.
2003-08-19

Proteasome inhibitors disrupt the unfolded protein response in myeloma cells

Kenneth C. Anderson, Ann-Hwee Lee, Laurie Glimcher
2003-04-01

Chemosensitivity linked to p73 function

María Carmen Marin, William C Hahn
2002-04-29

Dislocation and degradation from the ER are regulated by cytosolic stress

Article - wd:Q37100742

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