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AID dysregulation in lupus-prone MRL/Fas(lpr/lpr) mice increases class switch DNA recombination and promotes interchromosomal c-Myc/IgH loci translocations: modulation by HoxC4

forfatter

Ahmed Al-Qahtani

udgivet i: Autoimmunity

dato for udgivelse: 2011-05-18

Cites articles 84

Date

Titel

Forfattere

2011-04-01

Activation-induced deaminase-deficient MRL/lpr mice secrete high levels of protective antibodies against lupus nephritis
2011-01

Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions

Ahmed Al-Qahtani, Paolo Giovanni Casali, Jinsong Zhang
2010-09-20

Estrogen receptors bind to and activate the HOXC4/HoxC4 promoter to potentiate HoxC4-mediated activation-induced cytosine deaminase induction, immunoglobulin class switch DNA recombination, and somatic hypermutation

Jinsong Zhang
2010-08-30

Somatic hypermutation as a generator of antinuclear antibodies in a murine model of systemic autoimmunity
2010-06-16

Deletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus mice

David Nemazee, Rosana Gonzalez-Quintial
2010-02-01

Autoantibody-dependent and autoantibody-independent roles for B cells in systemic lupus erythematosus: past, present, and future
2010-02-01

The biology of reactive intermediates in systemic lupus erythematosus
2010-02-01

Systems biology of lupus: mapping the impact of genomic and environmental factors on gene expression signatures, cellular signaling, metabolic pathways, hormonal and cytokine imbalance, and selecting targets for treatment

Andras Perl
2010-08-22

14-3-3 adaptor proteins recruit AID to 5'-AGCT-3'-rich switch regions for class switch recombination

Jinsong Zhang, Seok-Rae Park
2009-11-01

AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations

Michel C. Nussenzweig, Niklas Feldhahn
2009-12-01

Dysregulation of germinal centres in autoimmune disease

Carola Garcia de Vinuesa, Iñaki Sanz
2009-10-20

A coming-of-age story: activation-induced cytidine deaminase turns 10.

Nina Papavasiliou
2009-07-27

Malignancies in systemic lupus erythematosus

Peter Szodoray
2009-05-01

Lupus and cancer

Caroline Gordon, Sasha Bernatsky, Rosalind Ramsey-Goldman
2009-05

HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation

Ahmed Al-Qahtani, Paolo Giovanni Casali, Jinsong Zhang
2009-02-01

Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination

Jinsong Zhang, Seok-Rae Park
2009-06-01

Decrease in glomerulonephritis and Th1-associated autoantibody production after progesterone treatment in NZB/NZW mice.

Edward A. Clark
2008-09-01

Nature and functions of autoantibodies
2008-08-04

AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development

Wendy Dubois
2008-06-01

Hormonal regulation of B-cell function and systemic lupus erythematosus
2008-05

MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation

Bernardo Reina San-Martin, Klaus Rajewsky, Michel C. Nussenzweig, Anna Gazumyan, Davide F. Robbiani, Thomas R Eisenreich, Kevin M McBride, Mila Jankovic, Michela Di Virgilio, Tanja A Schwickert
2008-04-02

Cancer risk in a cohort of patients with systemic lupus erythematosus (SLE) in California
2008-01-01

Mechanism and regulation of class switch recombination

Jeroen E Guikema, Carol E. Schrader
2008-03-01

Molecular mechanisms of autoimmunity
2008-01-01

The biochemistry of somatic hypermutation

Matthew D Scharff
2008-08-28

AID- and Ung-dependent generation of staggered double-strand DNA breaks in immunoglobulin class switch DNA recombination: a post-cleavage role for AID.
2008-06-20

Activation-induced deaminase heterozygous MRL/lpr mice are delayed in the production of high-affinity pathogenic antibodies and in the development of lupus nephritis
2007

Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombination

Ahmed Al-Qahtani, Paolo Giovanni Casali
2007-01-01

Immunoglobulin somatic hypermutation

Nina Papavasiliou
2007-06-01

Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice
2007-01-01

DNA replication to aid somatic hypermutation
2007-01-01

Molecular mechanisms of antibody somatic hypermutation

Javier M Di Noia

Artikel - wd:Q37146254

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