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TLR4/MyD88/PI3K interactions regulate TLR4 signaling

published in: Journal of Leukocyte Biology

date of publication: 2009-03-16

main subject: toll-like receptor

Cites articles 66

Date

Title

Authors

2008-11-01

IFN-beta production by TLR4-stimulated innate immune cells is negatively regulated by GSK3-beta
2008-03-01

Genetic analysis of the role of the PI3K-Akt pathway in lipopolysaccharide-induced cytokine and tissue factor gene expression in monocytes/macrophages
2008-02-01

Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors

Janet A Willment, Philip R Taylor, Victor Tybulewicz, Hector M. Mora-montes, Neil A. R. Gow, Mihai Netea
2007-03-28

Role of TLR4 tyrosine phosphorylation in signal transduction and endotoxin tolerance
2006-10-19

The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation

Patrick T Walsh
2006-06-02

Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling

Ruslan Medzhitov
2006-06-05

Phosphatidylcholine-specific phospholipase C (PC-PLC) is required for LPS-mediated macrophage activation through CD14.
2006-05-01

TLR5-mediated phosphoinositide 3-kinase activation negatively regulates flagellin-induced proinflammatory gene expression

Andrew T Gewirtz
2006-04-27

Role of MyD88 in phosphatidylinositol 3-kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells
2006-02-03

Enhancement of cytokine-mediated NF-kappaB activation by phosphatidylinositol 3-kinase inhibitors in monocytic cells
2006-01-26

MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction

Aisling Dunne, Sarah L Doyle, Luke A. J. O'Neill
2006-08-15

Contribution of interferon-beta to the murine macrophage response to the toll-like receptor 4 agonist, lipopolysaccharide

Eleanor N. Fish
2005-07-01

Differential involvement of BB loops of toll-IL-1 resistance (TIR) domain-containing adapter proteins in TLR4- versus TLR2-mediated signal transduction.
2005-07-01

Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappa B activation and IFN-beta synthesis downstream of Toll-like receptor 3 and 4

Ezra Aksoy, Wim Vanden Berghe
2005-03-08

Peptide-mediated interference of TIR domain dimerization in MyD88 inhibits interleukin-1-dependent activation of NF-{kappa}B

Claudio Sette
2004-10-24

Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling

Saumendra N Sarkar
2004-10-01

Toll-like receptors in the pathogenesis of human disease
2004-09-14

The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades

Harry Björkbacka, Douglas T Golenbock
2004-01-01

Adjuvant-mediated tumor regression and tumor-specific cytotoxic response are impaired in MyD88-deficient mice
2003-04

The role of PI3K in immune cells
2003-01-20

Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4

Jürg Tschopp
2003-08-01

Phosphoinositide 3 kinase mediates Toll-like receptor 4-induced activation of NF-kappa B in endothelial cells
2003-01-01

Induction of in vitro reprogramming by Toll-like receptor (TLR)2 and TLR4 agonists in murine macrophages: effects of TLR "homotolerance" versus "heterotolerance" on NF-kappa B signaling pathway components
2003-08-25

YXXM motifs in the PDGF-beta receptor serve dual roles as phosphoinositide 3-kinase binding motifs and tyrosine-based endocytic sorting signals
2003-07-29

Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88

Mikael Ejdebäck, Aisling Dunne, Luke A. J. O'Neill
2003-07-15

Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids
2003-07-01

Role of the phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharide
2003-03-01

Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages
2003-06-01

Myeloid differentiation factor 88-dependent and -independent pathways in toll-like receptor signaling
2003-07-01

ELAM-1/E-selectin promoter contains an inducible AP-1/CREB site and is not NF-kappa B-specific

Liselotte Jensen
2002-11-01

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.

Shizuo Akira
2002-07-01

Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation

Ken J. Ishii, Mayda Gürsel, Ihsan Gursel

Article - wd:Q37232951

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