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A randomized, double-blind, placebo-controlled crossover study of α4β 2* nicotinic acetylcholine receptor agonist AZD1446 (TC-6683) in adults with attention-deficit/hyperactivity disorder

published in: Psychopharmacology

date of publication: 2013-05-03

main subject: placebo, attention deficit hyperactivity disorder, attention

Cites articles 57

Date

Title

Authors

2012-11-29

Nicotinic agonist-induced improvement of vigilance in mice in the 5-choice continuous performance test
2012-06-01

A randomized pilot study of the efficacy and safety of ABT-089, a novel α4β2 neuronal nicotinic receptor agonist, in adults with attention-deficit/hyperactivity disorder
2012-07-27

Discovery of 3-(5-chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders
2012-02-21

A cognitive phenotype for a polymorphism in the nicotinic receptor gene CHRNA4.

Thomas Espeseth
2012-02

Efficacy and safety of the novel α₄β₂ neuronal nicotinic receptor partial agonist ABT-089 in adults with attention-deficit/hyperactivity disorder: a randomized, double-blind, placebo-controlled crossover study
2012-04-20

Effects of AZD3480, a neuronal nicotinic acetylcholine receptor agonist, and donepezil on dizocilpine-induced attentional impairment in rats.

Edward D Levin
2011-12-06

Abnormal functional connectivity in children with attention-deficit/hyperactivity disorder

Nora D. Volkow
2011-12

Deficits in attentional control: cholinergic mechanisms and circuitry-based treatment approaches
2011-10-04

Manipulation of nicotinic acetylcholine receptors differentially affects behavioral inhibition in human subjects with and without disordered baseline impulsivity

Alexandra Potter
2011-07-15

Assaying dissociable elements of behavioural inhibition and impulsivity: translational utility of animal models

Trevor Humby
2011-06-28

Cognitive control in adolescence: neural underpinnings and relation to self-report behaviors

Jessica R Andrews-Hanna
2011-04-27

A review of fronto-striatal and fronto-cortical brain abnormalities in children and adults with Attention Deficit Hyperactivity Disorder (ADHD) and new evidence for dysfunction in adults with ADHD during motivation and attention

Ana Cubillo, Katya Rubia
2011-10-01

Animal models to guide clinical drug development in ADHD: lost in translation?

Brian Hyland
2011-10-01

The utility of rat models of impulsivity in developing pharmacotherapies for impulse control disorders
2011-01-01

Nicotine up-regulates alpha4beta2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning

Julie M Miwa, Çağdaş Son, Fraser J Moss
2011-08-01

Nicotinic acetylcholine receptor β2 subunits in the medial prefrontal cortex control attention.

Karine Guillem, Sabine Spijker, Huibert D. Mansvelder, Bernard Bloem
2011-01-28

Sazetidine-A, a selective α4β2 nicotinic acetylcholine receptor ligand: effects on dizocilpine and scopolamine-induced attentional impairments in female Sprague-Dawley rats

Edward D Levin
2010-11-25

Safety and efficacy of ABT-089 in pediatric attention-deficit/hyperactivity disorder: results from two randomized placebo-controlled clinical trials

Ann C. Childress
2010-02-10

Enhancement of attentional performance by selective stimulation of alpha4beta2(*) nAChRs: underlying cholinergic mechanisms

William Howe
2009-06-23

Stimulation of dopamine release by nicotinic acetylcholine receptor ligands in rat brain slices correlates with the profile of high, but not low, sensitivity alpha4beta2 subunit combination
2009-10-01

Selectivity of ABT-089 for alpha4beta2* and alpha6beta2* nicotinic acetylcholine receptors in brain
2009-03-21

Target site occupancy: emerging generalizations from clinical and preclinical studies
2009-12-01

Characteristics of placebo responders in pediatric clinical trials of attention-deficit/hyperactivity disorder

Jeffrey Newcorn, Graham J. Emslie
2009-11-01

A method for cross-cultural adaptation of a verbal memory assessment

Peter J. Snyder, Paul Maruff, Lucette Cysique, Robert H Pietrzak
2008-09-15

Greater nicotinic acetylcholine receptor density in smokers than in nonsmokers: a PET study with 2-18F-FA-85380.
2008-06-18

Ventral striatal dopamine release in response to smoking a regular vs a denicotinized cigarette

Edythe D. London, Zoe Allen-Martinez, Arthur L Brody, David Scheibal, Judah Farahi
2008-05-01

Structural answers and persistent questions about how nicotinic receptors work
2008-02-01

ADHD from a socio-economic perspective

Sam Nordfeldt
2007-09-26

Acute nicotine improves cognitive deficits in young adults with attention-deficit/hyperactivity disorder
2007-07-01

Epidemiology of attention-deficit/hyperactivity disorder across the lifespan

Luis Augusto Rohde, Guilherme V Polanczyk
2007-06

The worldwide prevalence of ADHD: a systematic review and metaregression analysis

Joseph Biederman, Luis Augusto Rohde, Guilherme V Polanczyk
2007-01-16

Effects of TC-1734 (AZD3480), a selective neuronal nicotinic receptor agonist, on cognitive performance and the EEG of young healthy male volunteers

Article - wd:Q37337365

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