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New β-lactam antibiotics and β-lactamase inhibitors

published in: Expert Opinion on Therapeutic Patents

date of publication: 2010-10-01

language: English

main subject: antibiotic

Cites articles 31

Date

Title

Authors

2010-03

Updated functional classification of beta-lactamases
2010-03-22

In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli
2010-03-12

Inhibition of metallo-beta-lactamases by pyridine monothiocarboxylic acid analogs
2010-06-03

Detection of the new metallo-beta-lactamase VIM-19 along with KPC-2, CMY-2 and CTX-M-15 in Klebsiella pneumoniae
2009-05-09

Activity of cephalosporin CXA-101 (FR264205) against Pseudomonas aeruginosa and Burkholderia cepacia group strains and isolates.

David M. Livermore
2009-01-01

Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America
2009-02-02

Efficacy of piperacillin combined with the Penem beta-lactamase inhibitor BLI-489 in murine models of systemic infection

Patricia A. Bradford
2009-10-01

Antibiotic resistance in bacteria: novel metalloenzyme inhibitors
2008-03-01

A randomized, double-blind trial comparing ceftobiprole medocaril with vancomycin plus ceftazidime for the treatment of patients with complicated skin and skin-structure infections.
2008-06-30

In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections
2008-07-24

Synthesis and SAR of novel parenteral anti-pseudomonal cephalosporins: discovery of FR264205.
2008-10-01

Reduction of in-source collision-induced dissociation and thermolysis of sulopenem prodrugs for quantitative liquid chromatography/electrospray ionization mass spectrometric analysis by promoting sodium adduct formation
2008-12-15

In vitro activity of LK-157, a novel tricyclic carbapenem as broad-spectrum {beta}-lactamase inhibitor
2008-11-10

Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489.

Patricia A. Bradford
2008-08-09

NXL104 combinations versus Enterobacteriaceae with CTX-M extended-spectrum beta-lactamases and carbapenemases.

Neil Woodford, David M. Livermore, Shazad Mushtaq
2007-11-01

Emerging cephalosporins
2007-10

Phase 2 study of ceftaroline versus standard therapy in treatment of complicated skin and skin structure infections
2007-08-23

4-Substituted trinems as broad spectrum beta-lactamase inhibitors: structure-based design, synthesis, and biological activity
2006-08-08

Anti-MRSA beta-lactams in development
2006-03-01

The deacylation mechanism of AmpC beta-lactamase at ultrahigh resolution

George Minasov, Fabio Prati
2005-03-01

In vitro activity of tebipenem, a new oral carbapenem antibiotic, against penicillin-nonsusceptible Streptococcus pneumoniae
2004-08-01

Thermodynamic evaluation of a covalently bonded transition state analogue inhibitor: inhibition of beta-lactamases by phosphonates
2003-08-01

Crystal structure of Enterobacter cloacae 908R class C beta-lactamase bound to iodo-acetamido-phenyl boronic acid, a transition-state analogue

Johan Wouters
2001-08-24

Succinic acids as potent inhibitors of plasmid-borne IMP-1 metallo-beta-lactamase
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TOC-39, a novel parenteral broad-spectrum cephalosporin with excellent activity against methicillin-resistant Staphylococcus aureus
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Kinetic interactions of tazobactam with beta-lactamases from all major structural classes
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Cir and Fiu proteins in the outer membrane of Escherichia coli catalyze transport of monomeric catechols: study with beta-lactam antibiotics containing catechol and analogous groups
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In vitro activity of CP-65,207, a new penem antimicrobial agent, in comparison with those of other agents
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Iron-regulated outer membrane proteins of Escherichia coli K-12 and mechanism of action of catechol-substituted cephalosporins
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Interaction of azthreonam and related monobactams with beta-lactamases from gram-negative bacteria
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BRL 17421, a novel beta-lactam antibiotic, highly resistant to beta-lactamases, giving high and prolonged serum levels in humans

Article - wd:Q37788685

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