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Roles for KRAS in pancreatic tumor development and progression

published in: Gastroenterology

date of publication: 2013-06-01

language: English

Cites articles 82

Date

Title

Authors

2013-01-21

Oncogenic K-Ras requires activation for enhanced activity

Jaroslaw Daniluk
2013-02-28

Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer

Manuela Baccarini, Dario Alessi, Maren Hieber, Angelika Schnieke, Anna Melissa Schlitter, Irene Esposito
2013-04-01

Prostaglandin E2 regulates pancreatic stellate cell activity via the EP4 receptor
2012-12-03

Metastatic pancreatic cancer is dependent on oncogenic Kras in mice
2012-10-24

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

Ralph H. Hruban, Steven Garcia, Angelika N Christ, John V. Pearson, Christina K. Yung, Timothy Beck, Lorraine A Chantrill, Marc D. Jones, Mark Pinese, Vincenzo Corbo, Marina Pajic, Alistair G Rust, Mark J. Cowley, David K Chang, Neil D. Merrett, Roger J. Daly, Nicole Cloonan, John McPherson, Andrew Biankin, Giampaolo Tortora, Ming-Sound Tsao, Aldo Scarpa, Kyle Chang, Rita A Lawlor, Andreia V Pinho, Stefano Serra, Sean Grimmond, James G Kench, Nicola J Waddell, Venessa T Chin, Lincoln Stein, Neal G. Copeland, Nancy A. Jenkins, Christine A Iacobuzio-Donahue, David Tuveson, Christopher L Wolfgang, Richard D Schulick, Anirban Maitra, Gloria M Petersen, Donna Muzny, David A Largaespada, Richard A Gibbs, David A. Wheeler, Lora Lewis, Huyen H Dinh, Christian Buhay, Thomas J. Hudson, James R Eshleman, Robert E Denroche, Lee Timms, Nicholas Buchner, Richard de Borja, David K Miller, Australian Pancreatic Cancer Genome Initiative
2012-09-25

Cancer cell metabolism: one hallmark, many faces

David M. Sabatini
2012-09-01

EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma

Alberto J Schuhmacher, Carmen Guerra, Maria Sibilia
2012-09-01

EGF receptor is required for KRAS-induced pancreatic tumorigenesis

Clara Lubeseder-Martellato, Barbara M Grüner, Pawel K Mazur, Debjani Pal, David W. Threadgill, Maria Sibilia
2012-08-31

K-RAS mutant pancreatic tumors show higher sensitivity to MEK than to PI3K inhibition in vivo

Maria Schwaederle
2012-08-07

KRAS(G12D)- and BRAF(V600E)-induced transformation of murine pancreatic epithelial cells requires MEK/ERK-stimulated IGF1R signaling

David S Klimstra
2012-08-06

MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer

Michael A. Hollingsworth
2012-06-21

Genome-wide somatic copy number alterations in low-grade PanINs and IPMNs from individuals with a family history of pancreatic cancer

Michael Goggins, Ralph H. Hruban, Alison P Klein, Marcia Irene Canto, Michael Borges, Noriyuki Omura, Mitsuro Kanda
2012-06-01

Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia

Dafna Bar-Sagi
2012-06-01

Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer

Gregory L Beatty
2012-05-24

A central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma

Shenda Gu, Roch-Philippe Charles, Wayne A. Phillips, Joe W Gray, Laura M Heiser, Eric Collisson, Paul Spellman
2012-04-01

Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

Lewis C. Cantley, Lynda Chin, Hongwu Zheng, Jason W. Locasale, Ralph Weissleder, Ronald A. DePinho
2012-03-30

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

Christine Feig, Natalie Cook, David Tuveson
2012-03-20

Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma

Carlos Cuevas
2012-03-19

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

Daniel J. Anderson, Benjamin P Fauber, David Stokoe
2012-03-12

An NF-κB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice

Jaroslaw Daniluk
2012-01-09

Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
2012-01-05

Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia

Seung-Mo Hong, Anirban Maitra, Michael Goggins, Ralph H. Hruban, Bert Vogelstein, Kenneth W Kinzler, Michael Borges, Hanno Matthaei, Mitsuro Kanda
2011-11-24

StellaTUM: current consensus and discussion on pancreatic stellate cell research

Günter Klöppel, Claus Kordes, Jeremy S. Wilson, Minoti V. Apte, Thomas Gress, Atsushi Masamune, Helmut Friess, Mert Erkan, Irene Esposito, Guido Adler, Christoph W Michalski, Malte Buchholz, Carolin Reiser-Erkan
2011-10-13

RAS oncogenes: weaving a tumorigenic web

Dafna Bar-Sagi, Elda Grabocka
2011-11

Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers

Kwok Kin Wong, Jeffrey A Meyerhardt
2011-10-05

Mast cells in tumor microenvironment promotes the in vivo growth of pancreatic ductal adenocarcinoma

Ying Ma, Huamin Wang
2011-03-01

Ras in cancer and developmental diseases
2011-03-01

The RalGEF-Ral Effector Signaling Network: The Road Less Traveled for Anti-Ras Drug Discovery

David J. Reiner
2011-07-17

An orthosteric inhibitor of the Ras-Sos interaction

Dafna Bar-Sagi
2011-04-01

Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression

Sam C Wang, Kenneth Boucher, Akihisa Fukuda
2011-03

Hallmarks of Cancer: The Next Generation

Douglas Hanahan, Robert Weinberg
2011-02-01

Phenotypic changes in mouse pancreatic stellate cell Ca2+ signaling events following activation in culture and in a disease model of pancreatitis

Article - wd:Q38102106

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