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Fragment-based inhibitor discovery against β-lactamase

author

Adam R Renslo

published in: Future Medicinal Chemistry

date of publication: 2014-03-01

Cites articles 110

Date

Title

Authors

2013-09-27

Kinetics of avibactam inhibition against Class A, C, and D β-lactamases
2013-11-19

Class D β-lactamases: a reappraisal after five decades

Robert A Bonomo
2013-07-01

Targeting metallo-β-lactamase enzymes in antibiotic resistance
2013-07-12

The 'rule of three' for fragment-based drug discovery: where are we now?
2013-04-28

Metallo-β-lactamase: inhibitors and reporter substrates
2013-06

Structural Insight into Potent Broad-Spectrum Inhibition with Reversible Recyclization Mechanism: Avibactam in Complex with CTX-M-15 and Pseudomonas aeruginosa AmpC -Lactamases

Manuela Benvenuti, Jean-Denis Docquier, Stefano Mangani, Filomena De Luca
2013-01

Structural Insights into the Subclass B3 Metallo- -Lactamase SMB-1 and the Mode of Inhibition by the Common Metallo- -Lactamase Inhibitor Mercaptoacetate
2013-03-25

In vitro activity of Biapenem plus RPX7009, a carbapenem combined with a serine β-lactamase inhibitor, against anaerobic bacteria

Ellie J. C. Goldstein, Kerin L. Tyrrell, Diane M. Citron, C. Vreni Merriam
2013-08-16

Assay platform for clinically relevant metallo-β-lactamases

Anna M Rydzik, Christopher J. Schofield, Colin W G Fishwick, Ricky Cain, Ramya Salimraj
2013-04-10

Activity of biapenem (RPX2003) combined with the boronate β-lactamase inhibitor RPX7009 against carbapenem-resistant Enterobacteriaceae

David M. Livermore
2013-01-01

Fragment-based lead discovery grows up.

Monya Baker
2012-11-16

Metallo-β-lactamase structure and function
2012-10-05

Fragment-guided design of subnanomolar β-lactamase inhibitors active in vivo

Guillaume Dalmasso, Emilia Caselli, Fabio Prati
2012-08-10

2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-β-lactamases

Sandeep Sundriyal
2012-07-02

Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor
2012-07-18

New Delhi metallo-β-lactamase: structural insights into β-lactam recognition and inhibition
2012-06-14

Fragment-based approaches in drug discovery and chemical biology

Sean A Hudson, Anthony G Coyne
2012-02-14

Structure-based design of potent and ligand-efficient inhibitors of CTX-M class A β-lactamase

Emmanuel Smith, Adam R Renslo
2012-01-11

Kinetic characterization of a slow-binding inhibitor of Bla2: thiomaltol
2012-07-01

N-heterocyclic dicarboxylic acids: broad-spectrum inhibitors of metallo-β-lactamases with co-antibacterial effect against antibiotic-resistant bacteria
2012-03-27

Experiences in fragment-based drug discovery
2012-09-03

Activity of carbapenems with ME1071 (disodium 2,3-diethylmaleate) against Enterobacteriaceae and Acinetobacter spp. with carbapenemases, including NDM enzymes.

David M. Livermore
2012-07-23

Synthesis and kinetic testing of tetrahydropyrimidine-2-thione and pyrrole derivatives as inhibitors of the metallo-β-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa

Waleed M Hussein, Ross McGeary, Gerhard Schenk
2011-11-06

3-mercapto-1,2,4-triazoles and N-acylated thiosemicarbazides as metallo-β-lactamase inhibitors

Ross McGeary, Waleed M Hussein, Gerhard Schenk
2011-05-01

Status report on carbapenemases: challenges and prospects

Robert A Bonomo
2011-04-13

The identification of new metallo-β-lactamase inhibitor leads from fragment-based screening

Waleed M Hussein, Natasa Mitić, Gerhard Schenk, Ross McGeary
2011-08

Crystal structure of NDM-1 reveals a common β-lactam hydrolysis mechanism
2011-01-01

Practical aspects of NMR-based fragment screening
2011-01-01

From experimental design to validated hits a comprehensive walk-through of fragment lead identification using surface plasmon resonance
2011-01-01

Using computational techniques in fragment-based drug discovery
2010-09-29

The future of the β-lactams

Leticia I Llarrull, Jed F. Fisher, Shahriar Mobashery
2010-10

High-Resolution Crystal Structure of the Subclass B3 Metallo- -Lactamase BJP-1: Rational Basis for Substrate Specificity and Interaction with Sulfonamides

Manuela Benvenuti, Vito Calderone, Gian Maria Rossolini, Jean-Denis Docquier, Stefano Mangani

Article - wd:Q38196443

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