Paul A Clarke

formació a: St George's, University of London, Universitat de Leicester

ocupació: investigador

lloc web oficial: www.icr.ac.uk/our-research/researchers-and-teams/dr-paul-clarke

Sèrie

There is nothing here

Create a new serie

Treballs

There is nothing here

Create a new work

Articles 67

Date

Títol

Autors

2020-02-17

The kinase polypharmacology landscape of clinical PARP inhibitors

Albert Antolín Santaliestra, Malaka Ameratunga, Udai Banerji, Paul A Clarke, Paul Workman, Bissan Al-Lazikani
2020-02-24

Correction: Signalling involving MET and FAK supports cell division independent of the activity of the cell cycle-regulating CDK4/6 kinases

Simon R Stockwell, Paul A Clarke, Paul Workman
2020-03-11

CHK1 inhibition is synthetically lethal with loss of B-family DNA polymerase function in human lung and colorectal cancer cells

Rebecca F Rogers, Mike I Walton, Daniel L Cherry, Ian Collins, Paul A Clarke, Michelle D Garrett, Paul Workman
2020-05-05

A genome-scale CRISPR screen identifies the ERBB and mTOR signalling networks as key determinants of response to PI3K inhibition in pancreatic cancer

Charlotte K Milton, Paul A Clarke, Udai Banerji, David E Root, Steven Whittaker, Federica Piccioni
2020-06-23

A PI3K- and GTPase-independent Rac1-mTOR mechanism mediates MET-driven anchorage-independent cell growth but not migration

Alexia Hervieu, Sara Farrah Heuss, Chi Zhang, Rachel Barrow-McGee, Carine Joffre, Paul A Clarke, Stéphanie Kermorgant
2020-07-09

Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer

Paul A Clarke, Daniella Zheleva, Sheelagh Frame
2019-01-14

The off-target kinase landscape of clinical PARP inhibitors

Paul A Clarke, Udai Banerji, Paul Workman
2019-01-21

Small-molecule targeting of brachyury transcription factor addiction in chordoma

Tanaz Sharifnia, Ting Chen, Matthew Lawlor, Glenn S Cowley, Francisca Vazquez, Nathanael Gray, Paul A Clarke, Jay Bradner, Charles Y Lin, Joanne D Kotz, Stuart Schreiber, William C Hahn, David E Root, Barbara A Weir
2019-07-12

Signalling involving MET and FAK supports cell division independent of the activity of the cell cycle-regulating CDK4/6 kinases

Simon R Stockwell, Florence Raynaud, Paul A Clarke, Paul Workman, Sibylle Mittnacht
2019-03-25

Dissecting mechanisms of resistance to targeted drug combination therapy in human colorectal cancer

Paul A Clarke
2018-01-05

Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766)

Paul A Clarke, Paul Workman, Matthew D Cheeseman, Keith Jones, Nicola E A Chessum, Elisa Pasqua, Birgit Wilding, Ian Collins, Bugra Ozer, Mark Stubbs, Rosemary Burke
2018-02-01

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

Paul A Clarke, Paul Workman, Matteo Fassan, Andrea Sottoriva, Simon P Robinson, Georgios Vlachogiannis, Somaieh Hedayat, Yann Jamin, Javier Fernández-Mateos, Andrea Lampis, Katherine Eason, Ian Huntingford, Rosemary Burke, Mihaela Rata, Dow-Mu Koh, Nina Tunariu, David J Collins, Inmaculada Spiteri, Sing Yu Moorcraft, Ian Chau, Maria Bali, Mahnaz Darvish-Damavandi, Hazel Lote, Zakaria Eltahir, Elizabeth C Smyth, Anguraj Sadanandam, Owen J Sansom, Naureen Starling, Chiara Braconi, Nicola Valeri, Johann Sebastian de Bono
2017-11-04

MIR21 drives resistance to Heat Shock Protein 90 inhibition in cholangiocarcinoma.

Michele Simbolo, Andrea Lampis, Pietro Carotenuto, Luciano Cascione, Paul A Clarke, Aldo Scarpa, Elizabeth C Smyth, Zakaria Eltahir, Chirag Nepal, Matteo Fassan, Jesper B. Andersen, Nicola Valeri, Chiara Braconi
2016-12-09

Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases

Paul A Clarke, Julian Blagg, Trevor Dale, Paul Workman, Felix Rohdich
2015-01-01

First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor, in patients with advanced solid tumors

Debashis Sarker, Richard Baird, Victor Moreno, Paul A Clarke, Florence Raynaud, Mark R. Lackner
2015-02-13

Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen

Trevor Dale, Florence Raynaud, Paul A Clarke, Felix Rohdich
2015-10-26

A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease

Trevor Dale, Paul A Clarke, Rahul S Samant, Paul Czodrowski, Elizabeth Fraser, Florence Raynaud, Felix Rohdich
2015-06-25

Drugging PI3K in cancer: refining targets and therapeutic strategies

Paul A Clarke, Paul Workman
2014-04-23

E3 ubiquitin ligase Cullin-5 modulates multiple molecular and cellular responses to heat shock protein 90 inhibition in human cancer cells

Rahul S Samant, Paul A Clarke, Paul Workman
2014-08-01

Lactate and choline metabolites detected in vitro by nuclear magnetic resonance spectroscopy are potential metabolic biomarkers for PI3K inhibition in pediatric glioblastoma

Paul A Clarke, Thomas R. Eykyn, Chris Jones, Martin Leach, Paul Workman
2013-10-01

The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design

Caterina Barillari, Paul A Clarke, Spiros Linardopoulos, Florence Raynaud, Keith Jones
2013-03-17

ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system

Paul A Clarke, Laurence Pearl, Rahul S Samant, Paul Workman
2013-06-28

Genome-based cancer therapeutics: targets, kinase drug resistance and future strategies for precision oncology

Bissan Al-Lazikani, Paul A Clarke, Paul Workman
2013-12-02

Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins

Chrisostomos Prodromou, Laurence Pearl, Paul A Clarke
2013-08-01

Combining trail with PI3 kinase or HSP90 inhibitors enhances apoptosis in colorectal cancer cells via suppression of survival signaling

Paul A Clarke, Paul Workman
2013-11-01

Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX.

Paul A Clarke, Paul Workman
2013-08-01

HSF1 in Translation.

Paul A Clarke, Paul Workman
2012-05-03

The association of PI3 kinase signaling and chemoresistance in advanced ovarian cancer

Mateus Crespo, Susana Miranda, Gerhardt Attard, Paul A Clarke, Udai Banerji, Johann Sebastian de Bono
2012-05-01

Sensitization of (colon) cancer cells to death receptor related therapies: a report from the FP6-ONCODEATH research consortium

Spiros Linardopoulos, Paul A Clarke, Juan Carlos Lacal, Jean-Claude Martinou, Boris Zhivotovsky, Paul Workman
2012-04-01

Personalized medicine: patient-predictive panel power

Paul A Clarke, Bissan Al-Lazikani, Paul Workman
2012-04-01

The expanding proteome of the molecular chaperone HSP90.

Paul A Clarke, Paul Workman
2011-03-01

Correlation of overall survival with gene expression profiles in a prospective study of resectable esophageal cancer.

David Cunningham, Ian Giddings, Paul A Clarke, Paul Workman

Human - wd:Q38546651

Welcome to Inventaire

la biblioteca dels teus amics i comunitats

saber més