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PDE4B as a microglia target to reduce neuroinflammation.

author

Zoe Hughes

published in: Glia

date of publication: 2016-04-01

main subject: microglia, neuronitis

Cites articles 118

Date

Title

Authors

2016-01-13

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2016-01-08

Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology

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Neuroinflammation in the pathophysiology of Parkinson's disease and therapeutic evidence of anti-inflammatory drugs

Taysa Bervian Bassani
2015-12-04

Central nervous system myeloid cells as drug targets: current status and translational challenges

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Etanercept in Alzheimer disease: A randomized, placebo-controlled, double-blind, phase 2 trial

Jessica L. Teeling, Clive Holmes
2015-01-01

SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β

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2015-03-14

Synthesis of [(11)C]GSK1482160 as a new PET agent for targeting P2X(7) receptor.
2015-02-05

The interplay between cyclic AMP, MAPK, and NF-κB pathways in response to proinflammatory signals in microglia
2015-01-01

Phosphodiesterase-4 (PDE4) molecular pharmacology and Alzheimer's disease

Alex B. Burgin
2015-04-01

Neuroinflammation in Alzheimer's disease

Bente Finsen, Alexei Verkhratsky, Koji Yamanaka, Stéphane Hunot, Olga Garaschuk, Charles A. Dinarello, Guy Brown, Tony Wyss-Coray, Douglas T Golenbock, Richard M Ransohoff, Terrence Town, Sally A Frautschy
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Microglia in the TBI brain: The good, the bad, and the dysregulated

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2015-01-12

Evidence for brain glial activation in chronic pain patients

Oluwaseun Akeju, Nicole R Zürcher, Vitaly Napadow, Ajay D Wasan, Ru-Rong Ji, Jacob M. Hooker
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Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists
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Role of translocator protein density, a marker of neuroinflammation, in the brain during major depressive episodes

Romina Mizrahi, Sylvain Houle, Grazyna Rajkowska
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Identification of a chronic non-neurodegenerative microglia activation state in a mouse model of peroxisomal β-oxidation deficiency

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Imaging Microglial Activation with TSPO PET: Lighting Up Neurologic Diseases?

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Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease

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2015-10-01

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Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: assessed with [(11)C]-PBR28

Nicole R Zürcher, Jacob M. Hooker, Merit E Cudkowicz
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Intrathecal injection of phosphodiesterase 4B-specific siRNA attenuates neuropathic pain in rats with L5 spinal nerve ligation.
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Discovery and Optimization of 4-(8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic Acid, an Improved PDE4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease (COPD)

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Follow-up evaluation of cognitive function in the randomized Alzheimer's Disease Anti-inflammatory Prevention Trial and its Follow-up Study
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Selective Phosphodiesterase 4B Inhibitors: A Review

Mohammed Afzal Azam
2014-12-10

Effect of biologics on depressive symptoms in patients with psoriasis: a systematic review

Janet Pope
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Structural basis for the design of selective phosphodiesterase 4B inhibitors

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2014-04-01

Microglial diversity by responses and responders

Uwe-Karsten Hanisch
2014-08-15

Discovery of triazines as selective PDE4B versus PDE4D inhibitors

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Changsong Wang, Enyou Li, Jinghui Shi
2014-04-09

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

Josef Priller, Marco Prinz

Article - wd:Q38796315

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