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Therapeutic targeting of splicing in cancer

published in: Nature Medicine

date of publication: 2016-09-01

language: English

Cites articles 118

Date

Title

Authors

2016-02-11

Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

Eric Billy
2016-02-11

MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

Aviad Tsherniak, Francisca Vazquez, Clary B Clish, Levi A Garraway, Todd Golub, William C Hahn, David E Root, Jesse S Boehm, Glenn S Cowley, Barbara A Weir
2016-02-04

Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage

Sophie Piperno-Neumann, Sergio Roman-Roman, Franck Tirode, Marc-Henri Stern, Martin Dutertre
2016-02-01

Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution

Chris Oubridge, Wojciech P Galej, Xiao-chen Bai, Sjors Scheres
2016-01-29

The 3.8 Å structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis

Yigong Shi
2016-01-07

Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages
2016-06-10

RNA splicing factors as oncoproteins and tumour suppressors

Eunhee Kim, Heidi Dvinge, Robert K. Bradley
2016-05-01

Spliceosomal gene mutations in myelodysplasia: molecular links to clonal abnormalities of hematopoiesis

Robert K. Bradley
2016-05-02

Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins

Benjamin Durham, Heidi Dvinge, Andrei Krivtsov, Chun-Wei Chen, Eunhee Kim, Camille Lobry, Akihide Yoshimi, Robert K. Bradley, Young Rock Chung, Omar Abdel-Wahab, Jean-Baptiste Micol, Stanley Chun-Wei Lee, James Palacino, Silvia Buonamici
2015-10-22

Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3' Splice Site Selection through Use of a Different Branch Point

Simona Colla, Guillermo Garcia-Manero
2015-10-29

Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

Robyn T Sussman, Marco Ruella, Nicole M Martinez, Andrei Thomas-Tikhonenko, Yoseph Barash, Stephan A Grupp, Simon F Lacey, Elad Jacoby
2015-10-05

Intron retention is a widespread mechanism of tumor-suppressor inactivation

Hyunchul Jung, Donghoon Lee, Woong-Yang Park, Dongwan Hong, Peter J Park
2015-10-01

SRSF1-Regulated Alternative Splicing in Breast Cancer

Frédéric H-T Allain, Adrian Robert Krainer, Antoine Cléry
2015-09-25

The Natural Product N-Palmitoyl-l-leucine Selectively Inhibits Late Assembly of Human Spliceosomes

Roger G Linington
2015-09-02

The spliceosome is a therapeutic vulnerability in MYC-driven cancer

Lukas Simon, Rocío Domínguez-Vidaña, Jessica K Hartman, Antrix Jain, Joel R Neilson, Xiang H-F Zhang
2015-09-11

Structure of a yeast spliceosome at 3.6-angstrom resolution

Yigong Shi
2015-08-12

An overview of the clinical application of antisense oligonucleotides for RNA-targeting therapies

Matthew J. Wood
2015-08-10

Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities

Jian Zhang, Abdullah M. Ali, Raúl Rabadán, James L. Manley
2015-08-05

Potential Antileukemia Effect and Structural Analyses of SRPK Inhibition by N-(2-(Piperidin-1-yl)-5-(Trifluoromethyl)Phenyl)Isonicotinamide (SRPIN340)

Éverton de Almeida Alves Barbosa, Marcelo Depólo Polêto, Jörg Kobarg, Róbson R Teixeira, Julio Cesar Borges, José Andres Yunes, Leandro L. Oliveira
2015-05-15

Widespread intron retention diversifies most cancer transcriptomes

Robert K. Bradley, Heidi Dvinge
2015-06-24

The architecture of the spliceosomal U4/U6.U5 tri-snRNP

Wojciech P Galej, Xiao-chen Bai, Sjors Scheres
2015-05-14

Inhibition of vemurafenib-resistant melanoma by interference with pre-mRNA splicing
2015-05-11

MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis

Soo-Yong Tan, Arianna Sabò, Bruno Amati
2015-05-01

SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition

Eunhee Kim, Robert K. Bradley, Yorgo Modis, Camille Lobry, Hans Joachim Deeg, Iannis Aifantis
2015-04-27

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

Kenneth W Duncan
2015-04-23

Identification of recurrent regulated alternative splicing events across human solid tumors

Miri Danan-Gotthold, Eli Eisenberg, Erez Y. Levanon
2015-04-10

Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B

Manoj K Kashyap, Chris Benner
2015-03-13

Transcriptome sequencing reveals potential mechanism of cryptic 3' splice site selection in SF3B1-mutated cancers

Christopher DeBoever, Kelly A. Frazer
2015-06

The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond

David Shechter
2015-01-12

Inhibitors of CLK protein kinases suppress cell growth and induce apoptosis by modulating pre-mRNA splicing

Shinsuke Araki
2015-03-18

A chemical genetics approach for the functional assessment of novel cancer genes.

Junxia Min
2015-07-22

Non-coding recurrent mutations in chronic lymphocytic leukaemia

Sílvia Beà, José I Martín-Subero, Carlota Rubio-Perez, Pedro Jares, Renée Beekman, Ana Carrió, Giancarlo Castellano, Guillem Clot, Enrique Colado, Dolors Colomer, Julio Delgado, Anna Enjuanes, Xavier Estivill i Pallejà, Josep Lluís Gelpí, Jesus Maria Hernandez Rivas, David Martín Garcia, Alba Navarro, Pilar Nicolás, David G. Pisano, Víctor Quesada, María Rozman, Itziar Salaverria, Maria José Terol, Alfonso Valencia, Núria López-Bigas, David Torrents, Carlos López Otín, Elías Campo, Hendrik Gerard Stunnenberg, Marta Aymerich, Modesto Orozco, Xose S. Puente, Ana M Queirós, Tycho Baumann, Magda Pinyol, Neus Villamor, Armando López-Guillermo, Rafael Valdés-Mas, Diana Puente, Mónica López-Guerra, Jesús Gutiérrez-Abril, Kostas Stamatopoulos

Article - wd:Q38948363

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