Inventaire - your friends and communities are your best library

ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons

author

Peer-Hendrik Kuhn

Stefan F Lichtenthaler

published in: The EMBO Journal

date of publication: 2010-07-30

language: English

Cites articles 55

Date

Title

Authors

2010-07-02

The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein

Elisabeth Kremmer, Jorg Tatzelt, Stefan F Lichtenthaler
2009-09-02

Metalloprotease ADAM10 is required for Notch1 site 2 cleavage

Raphael Kopan, Paul J van Diest, Elsken van der Wall
2009-10-23

Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10

Grace R Jeschke, Cristina I Caescu
2009-07-15

Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity

Robert D. Moir, Rudolph E. Tanzi
2009-02-19

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

Marc Tessier-Lavigne
2009-01-21

ADAMs 10 and 17 represent differentially regulated components of a general shedding machinery for membrane proteins such as transforming growth factor alpha, L-selectin, and tumor necrosis factor alpha
2009-08-24

Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling
2009-07-14

A novel pathway for amyloid precursor protein processing

Henrik Zetterberg, Kaj Blennow, Erik Portelius, Gunnar Brinkmalm, Ann Westman-Brinkmalm
2009-06-29

Role of ADAMs in the ectodomain shedding and conformational conversion of the prion protein

Edward Parkin, Nigel Mark Hooper, Alison E. Ashcroft, James Ault
2009-02-11

The effects of alpha-secretase ADAM10 on the proteolysis of neuregulin-1.
2008-11-13

The "a disintegrin and metalloprotease" (ADAM) family of sheddases: physiological and cellular functions
2008-11-01

Effects of TNFalpha-converting enzyme inhibition on amyloid beta production and APP processing in vitro and in vivo
2008-09-18

The good, the bad and the ugly substrates for ADAM10 and ADAM17 in brain pathology, inflammation and cancer

Andreas Ludwig
2008-05-23

A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein

Elisabeth Kremmer, Christian Haass, Peer-Hendrik Kuhn, Stefan F Lichtenthaler
2008-03-14

Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope

Konrad Beyreuther, William J McKinstry, Roberto Cappai, Michael W Parker, Colin L. Masters
2008-12-10

CSF APPs alpha and phosphorylated tau protein levels in mild cognitive impairment and dementia of Alzheimer's type.
2007-01-01

Role of the APP non-amyloidogenic signaling pathway and targeting alpha-secretase as an alternative drug target for treatment of Alzheimer's disease

Sanghamitra Bandyopadhyay
2007-09-01

Alpha-secretase as a therapeutic target
2007-10-24

Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation

Christian Haass
2006-10-27

Control of peripheral nerve myelination by the beta-secretase BACE1

Paul Saftig, Christian Haass, Alistair N Garratt, Carmen Birchmeier
2006-03

The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein

Katja Gehrig-Burger
2006-01-30

Expression cloning screen for modifiers of amyloid precursor protein shedding

Stefan F Lichtenthaler
2006-10-29

ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23

Jamie Sturgill, Andreas Ludwig
2005-12-12

Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein

Christian Haass, Stefan F Lichtenthaler
2005-03-18

P2Y2 nucleotide receptors enhance alpha-secretase-dependent amyloid precursor protein processing

Laurie Erb
2005-02-03

ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling

Andreas Ludwig
2004-03-01

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

Umut Sahin
2004-01-29

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

Christian Haass
2004-12-01

Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).
2004-06-01

The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein

Edward Parkin, Nigel Mark Hooper
2004-05-01

A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

Ilse Dewachter, Christoph Hiemke
2004-09-01

Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis

Thor D Stein, Mark Mattson

Article - wd:Q39672952

Welcome to Inventaire

the library of your friends and communities

learn more