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The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis

author

Antonio Costanzo

Roberto Lande

Camilla Jandus

Curdin Conrad

Loredana Frasca

published in: Nature Communications

date of publication: 2014-12-03

language: English

main subject: antimicrobial peptide

Cites articles 64

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Keratin 17: a critical player in the pathogenesis of psoriasis
2013-09-26

Chemokine receptors in psoriasis

Tej Pratap Singh
2013-04-10

CD38 and CD157: a long journey from activation markers to multifunctional molecules

Antonella Chillemi, Enrico Brunetti, Ada Funaro, Fabio Malavasi
2013-06-17

β-Defensin 2 and 3 promote the uptake of self or CpG DNA, enhance IFN-α production by human plasmacytoid dendritic cells, and promote inflammation
2013-10-11

Crosstalk between keratinocytes and T cells in a 3D microenvironment: a model to study inflammatory skin diseases
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Vaccine against autoimmune disease: antigen-specific immunotherapy

Robert P Anderson
2012-08-27

Cytosolic sensing of extracellular self-DNA transported into monocytes by the antimicrobial peptide LL37.

Robert Modlin, Roberto Lande
2012-07

IL-17A is essential for cell activation and inflammatory gene circuits in subjects with psoriasis

Mayte Suárez-Fariñas, James G. Krueger
2012-06-15

Etanercept downregulates the Th17 pathway and decreases the IL-17+/IL-10+ cell ratio in patients with psoriasis vulgaris

Emiliano Antiga, Laura Maggi
2012-12-03

Memory T cell subsets, migration patterns, and tissue residence

Thomas Gebhardt, Scott N. Mueller, William R Heath
2012-12-06

CD8(+) T cells in the lesional skin of atopic dermatitis and psoriasis patients are an important source of IFN-γ, IL-13, IL-17, and IL-22

Dirkjan Hijnen, Edward Frank Knol
2012-01-26

A single intradermal injection of IFN-γ induces an inflammatory state in both non-lesional psoriatic and healthy skin

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2012-11-15

CD8(+) T cells mediate RAS-induced psoriasis-like skin inflammation through IFN-γ
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LL-37 suppresses sodium nitroprusside-induced apoptosis of systemic sclerosis dermal fibroblasts

Hee Jung Kim
2011-11-24

CXCL16 and CXCR6 are upregulated in psoriasis and mediate cutaneous recruitment of human CD8+ T cells

Tilo Biedermann
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Ezrin, maspin, peroxiredoxin 2, and heat shock protein 27: potential targets of a streptococcal-induced autoimmune response in psoriasis
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Psoriasis

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Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis

Carmine Stolfi, Elena Campione, Antonio Costanzo
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Skin immune sentinels in health and disease

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Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8.

Dipyaman Ganguly, Tomasz Zal, Roberto Lande
2009-09-24

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Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells.

Antonio Lanzavecchia, Federica Sallusto, David Jarrossay
2009-11-01

Effective treatment of psoriasis with etanercept is linked to suppression of IL-17 signaling, not immediate response TNF genes

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Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells

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Evaluation of MHC-II peptide binding prediction servers: applications for vaccine research

Vladimir Brusic
2008-10-01

Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis

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2008-02-01

IFN-gamma arms human dendritic cells to perform multiple effector functions
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Pathogenesis and therapy of psoriasis

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2007-07-01

Pathogenesis and clinical features of psoriasis
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Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses.

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2007-10-04

Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide

Article - wd:Q41620801

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