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Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes.

author

Beate K Straub

Peter P Nawroth

1954 -

published in: Blood

date of publication: 2011-11-23

language: English

main subject: drotrecogin alfa

Cites articles 43

Date

Title

Authors

2011-03-09

Low but sustained coagulation activation ameliorates glucose-induced podocyte apoptosis: protective effect of factor V Leiden in diabetic nephropathy

Ilya A Vinnikov, Peter P Nawroth, Angelika Bierhaus
2009-10-19

Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells

Francis J Castellino, Rashid Deane
2009-10-15

Double-stranded DNA activates glomerular endothelial cells and enhances albumin permeability via a toll-like receptor-independent cytosolic DNA recognition pathway

Ramanjaneyulu Allam, Hans-Joachim Anders
2009-12-01

Activated protein C and acute kidney injury: Selective targeting of PAR-1.
2009-08-17

Hypercoagulability inhibits monocyte transendothelial migration through protease-activated receptor-1-, phospholipase-Cbeta-, phosphoinositide 3-kinase-, and nitric oxide-dependent signaling in monocytes and promotes plaque stability

Ilya A Vinnikov, Peter P Nawroth, Angelika Bierhaus
2009-04-01

Proteases display biased agonism at protease-activated receptors: location matters!
2009-03-01

Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity

Rashid Deane
2008-12-30

Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells

Yajnavalka Banerjee, Rolf T. Urbanus, Owen J T McCarty
2008-09-10

Inducible rodent models of acquired podocyte diseases

Peter Hauser
2008-09-01

The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A.
2008-03-01

The protease-activated receptor-3 (PAR-3) can signal autonomously to induce interleukin-8 release
2008-02-12

Lipid raft localization regulates the cleavage specificity of protease activated receptor 1 in endothelial cells.
2007-11-04

Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis

Ilya A Vinnikov, Triantafyllos Chavakis, Peter P Nawroth, Angelika Bierhaus
2007-10-28

'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage
2007-09-06

The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells
2007-03-21

Protease-activated receptor-3 (PAR3) regulates PAR1 signaling by receptor dimerization
2007-02-13

Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells
2007-04-15

The cytoprotective protein C pathway
2007-12-16

Modification of kidney barrier function by the urokinase receptor.

Mehmet M. Altintas, Karin Schwarz, Serena Zacchigna, Peter Cowan, Matthias Kretzler, Roberto Parrilla, Vineet Gupta, Raghu Kalluri, Peter Carmeliet
2007-10-11

Activated protein C decreases tumor necrosis factor related apoptosis-inducing ligand by an EPCR- independent mechanism involving Egr-1/Erk-1/2 activation
2007-04-04

Activated protein C ameliorates LPS-induced acute kidney injury and downregulates renal INOS and angiotensin 2.
2007-02-14

Role of protein C in renal dysfunction after polymicrobial sepsis

George E. Sandusky
2005-02-01

Proteinase-activated receptors (PARs)--the PAR3 Neo-N-terminal peptide TFRGAP interacts with PAR1.
2005-02-14

Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation
2005-01-21

PAR1 cleavage and signaling in response to activated protein C and thrombin.
2004-12-30

Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation
2004-02-19

Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3
2004-06-03

Activated protein C variants with normal cytoprotective but reduced anticoagulant activity
2004-06-01

Tethered ligand-derived peptides of proteinase-activated receptor 3 (PAR3) activate PAR1 and PAR2 in Jurkat T cells
2003-09-01

Oxytocin receptor elicits different EGFR/MAPK activation patterns depending on its localization in caveolin-1 enriched domains

Alessandra Reversi, Bice Chini, Maura Francolini, Elena Taverna
2003-06-01

Structure-based analysis of GPCR function: evidence for a novel pentameric assembly between the dimeric leukotriene B4 receptor BLT1 and the G-protein
2003-01-01

Cell biology of the glomerular podocyte

Matthias Kretzler

Article - wd:Q41773964

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