Jayvardhan Pandit

заклад освіти: Індійський науковий інститут, Індійський технологічний інститут в Делі

рід діяльності: дослідник

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Статті 39

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2016-02-24

A Novel Binding Mode Reveals Two Distinct Classes of NMDA Receptor GluN2B-selective Antagonists

Laetitia Mony, Pierre Paoletti, Jayvardhan Pandit
2015-05-28

The discovery and characterization of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiator N-{(3S,4S)-4-[4-(5-cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242)

Jayvardhan Pandit, Christopher J O'Donnell
2015-03-09

Engineered stabilization and structural analysis of the autoinhibited conformation of PDE4

Jayvardhan Pandit
2015-04-01

Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug-drug interactions with a novel series of centrally efficacious BACE1 inhibitors

Jayvardhan Pandit
2014-12-26

Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications

Matthew Doroski, Jayvardhan Pandit, Kathleen A Farley, Christopher J O'Donnell
2013-04-01

PF-04859989 as a template for structure-based drug design: identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency

Jayvardhan Pandit
2013-01-10

Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions

Jayvardhan Pandit
2013-06-01

Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, part I: transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors

Jayvardhan Pandit
2013-11-27

Discovery and characterization of a novel dihydroisoxazole class of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiators

Jayvardhan Pandit, Christopher J O'Donnell
2013-01-01

Allosteric modulators for the treatment of schizophrenia: targeting glutamatergic networks

Jayvardhan Pandit, P. Jeffrey Conn, Craig W. Lindsley
2013-03-29

Discovery of potent selective bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model. Part II: optimization studies and demonstration of in vivo efficacy.

Jayvardhan Pandit
2012-11-08

Discovery and optimization of a novel spiropyrrolidine inhibitor of β-secretase (BACE1) through fragment-based drug design

Jayvardhan Pandit
2012-01-25

Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia

Jayvardhan Pandit
2011-03-01

6-amino-4-(pyrimidin-4-yl)pyridones: novel glycogen synthase kinase-3β inhibitors

Jayvardhan Pandit
2011-06-08

Use of structure-based design to discover a potent, selective, in vivo active phosphodiesterase 10A inhibitor lead series for the treatment of schizophrenia

Jayvardhan Pandit, Judith A Siuciak, Frank S. Menniti
2010-06-24

Design of selective, ATP-competitive inhibitors of Akt

Jayvardhan Pandit, Deborah M. Gordon
2009-10-14

Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct

Jayvardhan Pandit, Frank S. Menniti
2009-08-01

Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia

Frank S. Menniti, Jayvardhan Pandit
2009-08-08

Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer's disease

Karl E. Richter, Frank S. Menniti, Jayvardhan Pandit
2009-12-01

Cyclic nucleotide binding GAF domains from phosphodiesterases: structural and mechanistic insights

Jayvardhan Pandit
2008-06-01

Synthesis and structure based optimization of novel Akt inhibitors

Jayvardhan Pandit
2007-01-01

Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors

Frank S. Menniti, Jayvardhan Pandit
2007-05

The 2.0 Å crystal structure of the ERα ligand-binding domain complexed with lasofoxifene

Jayvardhan Pandit
2007-09-29

Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13.

Jayvardhan Pandit
2006-08-30

Potent, selective pyrimidinetrione-based inhibitors of MMP-13

Jayvardhan Pandit
2005-04-01

Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14.

Jayvardhan Pandit
2005-09-01

Theoretical and experimental design of atypical kinase inhibitors: application to p38 MAP kinase

Jayvardhan Pandit
2003-02-01

Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TR beta subtype-selective thyromimetics

Robert L. Dow, Jayvardhan Pandit
2003-06-16

3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site

Jayvardhan Pandit
2002-08-29

Anilinoquinazoline inhibitors of fructose 1,6-bisphosphatase bind at a novel allosteric site: synthesis, in vitro characterization, and X-ray crystallography

Jayvardhan Pandit
2002-05-01

Synthesis and biological activity of selective pipecolic acid-based TNF-alpha converting enzyme (TACE) inhibitors

Jayvardhan Pandit
2000-08-11

Identification, characterization, and crystal structure of the Omega class glutathione transferases

Jayvardhan Pandit

Human - wd:Q42672744

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