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The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity.

author

Peter Wark

Nathan Bartlett

Nicole M Verrills

Anthony S. Don

Jonathan C. Morris

Sebastian L Johnston

published in: Nature Medicine

date of publication: 2013-01-20

language: English

main subject: asthma

Cites articles 43

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Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit α4, altering PP2A stability and microtubule-associated protein phosphorylation
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Active transport of the ubiquitin ligase MID1 along the microtubules is regulated by protein phosphatase 2A
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Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus

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Article - wd:Q43851423

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