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Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.

লেখক

Angeliki Malliri

এতে প্রকাশিত: নেচার

তারিখে প্রকাশিত: 2002-06-01

ভাষা: ইংরেজি ভাষা

Cites articles 27

তারিখ

শিরোনাম

লেখকগণ

2000-10-01

Ras and Rho GTPases: a family reunion
2000-12-07

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

John Sondek
2000-02-01

Integration of positive and negative growth signals during ras pathway activation in vivo
2000-08-01

High levels of phosphorylated c-Jun, Fra-1, Fra-2 and ATF-2 proteins correlate with malignant phenotypes in the multistage mouse skin carcinogenesis model.

Spiros Linardopoulos
2000-05-01

Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition
1999-09-01

Suppression of Ras-induced apoptosis by the Rac GTPase
1999-11-01

Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior
1998-01-23

Rho GTPases and the actin cytoskeleton
1998-07-01

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

Michael F. Olson
1998-05-01

The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis.

Stuart Yuspa
1998-08-01

Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo

Stuart Yuspa, Carol S. Trempus, Raymond W. Tennant
1998-11-01

Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase
1998-03-01

A causal role for E-cadherin in the transition from adenoma to carcinoma

Henrik Semb
1997-11-01

Inhibition of invasion of epithelial cells by Tiam1-Rac signaling
1997-12-01

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.
1997-01-01

Expression of Tiam-1 in the developing brain suggests a role for the Tiam-1-Rac signaling pathway in cell migration and neurite outgrowth

Elisabeth Ehler, Frank N van Leeuwen, Patricia C Salinas
1997-06-01

The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts

Vania M Braga, Neil A Hotchin
1997-11-01

Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells
1997-02-01

Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras.
1997-12-01

Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion
1995-09-01

An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1
1995-03-01

An essential role for Rac in Ras transformation
1995-11-01

Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation
1995-05-01

A role for Rac in Tiam1-induced membrane ruffling and invasion
1994-05-01

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins.
1993-09-01

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.
1986-07-01

Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis

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