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Exo-mechanism proximity-accelerated alkylations: investigations of linkers, electrophiles and surface mutations in engineered cyclophilin-cyclosporin systems

publicerad i: ChemBioChem

utgivningsår: 2005-05-01

Refererar artiklar 33

Datum

Titel

Författare

2004-08-01

A mechanism-based cross-linker for the identification of kinase-substrate pairs
2004-08-01

Making drugs on proteins: site-directed ligand discovery for fragment-based lead assembly
2004-06-01

TRAM linker: a safety-catch linker for the traceless release of acrylamides
2003-04-15

Structural model of the N-methyl-D-aspartate receptor glycine site probed by site-directed chemical coupling,Structural Model of the N-Methyl-D-aspartate Receptor Glycine Site Probed by Site-directed Chemical Coupling

Heinrich Betz
2003-11-11

On the benzodiazepine binding pocket in GABAA receptors,On the Benzodiazepine Binding Pocket in GABAA Receptors
2003-07-01

Reactivity of functional groups on the protein surface: development of epoxide probes for protein labeling

Gong Chen
2003-02-01

Chemical proteomics and its application to drug discovery.

Matthew Bogyo
2002-04-01

Inhibition of protein-protein association by small molecules: approaches and progress
2002-06-11

Studying gene function in eukaryotes by conditional gene inactivation
2002-08-01

Novel chemical genetic approaches to the discovery of signal transduction inhibitors
2002-02-01

Affinity labeling of cysteine-mutants evidences contact residues in modeled receptor binding sites
2002-02-01

Methionine proximity assay, a novel method for exploring peptide ligand-receptor interaction

Emanuel Escher, Antony A. Boucard
2002-05-01

Thiol-dependent enzymes and their inhibitors: a review
2002-02-01

Irreversible inhibitors of the erbB family of protein tyrosine kinases
2002-07-01

Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype

Benjamin Cravatt
2001-10-01

Conditional control of gene expression in the mouse
2001-04-01

Cysteine mutants as chemical sensors for ligand-receptor interactions
2001-07-10

Antibodies with infinite affinity
2001-11-01

Systematic modulation of Michael-type reactivity of thiols through the use of charged amino acids

Nicola Tirelli, Jeffrey A. Hubbell
2000-04-28

Mapping the agonist binding site of the nicotinic acetylcholine receptor. Orientation requirements for activation by covalent agonist
2000-08-01

Specific binding sites for alcohols and anesthetics on ligand-gated ion channels
2000-12-01

Mechanism of chalcone synthase. pKa of the catalytic cysteine and the role of the conserved histidine in a plant polyketide synthase.
2000-12-01

Chemical strategies for the global analysis of protein function
2000-08-15

Site-directed ligand discovery
1999-10-01

Evaluation and biological properties of reactive ligands for the mapping of the glycine site on the N-methyl-D-aspartate (NMDA) receptor.
1999-01-01

Reactive affinity probes for the mapping of the glycine-binding site of the NMDA receptor NR1 subunit.
1998-10-23

X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A

Malcolm Walkinshaw
1998-07-01

Calculations of electrostatic interactions and pKas in the active site of Escherichia coli thioredoxin.

H. Jane Dyson
1997-04-01

Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates
1996-12-01

His-8 lowers the pKa of the essential Cys-12 residue of the ArsC arsenate reductase of plasmid R773.

Barry P. Rosen
1993-09-01

Active site labeling of the Yersinia protein tyrosine phosphatase: the determination of the pKa of the active site cysteine and the function of the conserved histidine 402.
1993-01-01

X-ray structure of a decameric cyclophilin-cyclosporin crystal complex

Malcolm Walkinshaw

Artikel - wd:Q46439197

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