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Chemical probes and inhibitors of bromodomains outside the BET family.

author

Moses Moustakim

published in: MedChemComm

date of publication: 2016-09-07

Cites articles 118

Date

Title

Authors

2016-03-01

Development of chemical probes for the bromodomains of BRD7 and BRD9

Paul E Brennan
2016-09-12

A Chemical Probe for the ATAD2 Bromodomain

Tony Kouzarides, Paul Bamborough, Chun-Wa Chung, Andrew Bannister, Rab K Prinjha, Sam Robson, Ka Hing Che, Emmanuel H Demont, Rebecca C. Furze, Clement Douault, Anne-Marie Michon
2016-09

Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition
2016-05-09

GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain

Isabelle Becher, David J Fallon, Chun-Wa Chung
2016-06-10

Clinical progress and pharmacology of small molecule bromodomain inhibitors

Nicholas C.O. Tomkinson
2016-05-31

Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains

James R Kiefer, F. Anthony Romero, Andrea Cochran
2016-03-15

Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637)

F. Anthony Romero, Andrew R Conery, James R Kiefer, Andrea Cochran
2016

BRD7: a novel tumor suppressor gene in different cancers
2016-04-27

An Advanced Tool To Interrogate BRD9

Md Rezaul Karim
2016-04-27

Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex

Stefan Knapp, Steven V. Ley, Paul E Brennan, Cynthia Tallant
2016-04-26

Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit

Panagis Filippakopoulos, Ellen Berg, Susanne Müller, Stefan Knapp, Teresita Padilla-Benavides, Paul E Brennan, Sarah Picaud, Mark E Bunnage, Brian S Gerstenberger, John D Trzupek, Alison O'Mahony, Vita Fedele, Cynthia Tallant, Catherine Rogers
2016-03-24

miR-141 is involved in BRD7-mediated cell proliferation and tumor formation through suppression of the PTEN/AKT pathway in nasopharyngeal carcinoma

Ming Tan
2016-02-23

Bromodomain-containing protein 7 (BRD7) as a potential tumor suppressor in hepatocellular carcinoma
2016-05-26

Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor

Susanne Müller, Stefan Knapp, Cynthia Tallant
2016-01-08

Progress in the Development of non-BET Bromodomain Chemical Probes

Nicholas C.O. Tomkinson, Philip G Humphreys
2016-01-05

Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma

Adrianne Neiss, Andrew R Conery, Charles Hatton, Barbara Bryant
2016-01-05

Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain

Apirat Chaikuad, Susanne Müller, Stefan Knapp, Paul E Brennan
2016-02-25

Discovery of CREBBP Bromodomain Inhibitors by High-Throughput Docking and Hit Optimization Guided by Molecular Dynamics

Amedeo Caflisch, Dimitrios Spiliotopoulos, Cristina Nevado
2016-02-25

Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition

Gerard Drewes, Tony Kouzarides, Anne-Marie Michon, Paola Grandi, David Drewry, Antje Dittmann, Isabelle Becher, Andrew Bannister, Rab K Prinjha, Ka Hing Che
2015-11-13

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance

Oleg Fedorov, Matteo Aldeghi, John D Trzupek, Chas Bountra, Christopher Wells, Catherine Rogers, Philip C. Biggin, Paul E Brennan, Thomas Günther, Stefan Knapp, Stefan Knapp, Susanne Müller, Cynthia Tallant
2015-12-17

Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities

Thomas A. Lanz, Lyn H. Jones, Shenping Liu
2015-12-01

Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain Inhibitors

F. Anthony Romero
2015-12-01

Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy

Tony Kouzarides, Panagis Filippakopoulos, Andrew Bannister, Susanne Müller, Stefan Knapp, Heidi Olzscha, Paul E Brennan, Rab K Prinjha, Ka Hing Che, Dave Lugo, Carl Philpott, Sarah Picaud, Jürg Schwaller, Anthony Tumber, Chas Bountra, Alison O'Mahony, Octovia P Monteiro, Clarence Yapp, Angeliki Thanasopoulou, Katharina Leonards, Marjeta Urh, Danette Daniels
2015-11-09

The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome

Hossein Khiabanian, Raúl Rabadán, Teresa Palomero, Adolfo A Ferrando
2015-10-23

Discovery of Chemical Inhibitors of Human Bromodomains
2015-08-10

CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses

Paul E Brennan, Hussein Al-Mossawi, Jelle de Wit, Matteo Vecellio, Stefan Knapp, Paul Bowness, Cynthia Tallant, Paul Wordsworth
2015-08-13

Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain Inhibitors

Anne-Marie Michon, Paola Grandi
2015-07-28

Dual Screening of BPTF and Brd4 Using Protein-Observed Fluorine NMR Uncovers New Bromodomain Probe Molecules

Laura M L Hawk
2015-07-23

Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors

Anne-Marie Michon, Paola Grandi
2015-06-10

Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor

Jannik N Andersen, Michelle Craig Barton, Carlo Toniatti, Giulio F Draetta
2015-06-04

Fragment-Based Design of Selective Nanomolar Ligands of the CREBBP Bromodomain

Dimitrios Spiliotopoulos, Cristina Nevado, Amedeo Caflisch
2015-05-25

NanoBRET--A Novel BRET Platform for the Analysis of Protein-Protein Interactions

Article - wd:Q47128083

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