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Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases.

författare

Rohan A. Davis

Mélanie Roué

1984 -

Laurent Meijer

1953 -

Peter Proksch

Michelle Klautau

publicerad i: Marine Drugs

utgivningsår: 2017-10-17

huvudämne: svampdjur, enzym, mechanism of action, eukaryoter, alkaloid, imidazole

Refererar artiklar 40

Datum

Titel

Författare

2017-03-29

Current Status of Marine-Derived Compounds as Warheads in Anti-Tumor Drug Candidates

Gordon M. Cragg
2017-08-02

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature

Yann Hérault, Thierry Besson
2016-02-18

Drugs and Drug Candidates from Marine Sources: An Assessment of the Current "State of Play".

Gordon M. Cragg
2015-04-10

Leucettine L41, a DYRK1A-preferential DYRKs/CLKs inhibitor, prevents memory impairments and neurotoxicity induced by oligomeric Aβ25-35 peptide administration in mice

Laurent Givalois
2015-07-21

A historical overview of protein kinases and their targeted small molecule inhibitors

Robert Roskoski
2015-01-17

DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome

María Lourdes Arbonés, Simon J Cook
2015-05-12

FDA-approved small-molecule kinase inhibitors

Mads H Clausen
2015-03-24

Sponge grade body fossil with cellular resolution dating 60 Myr before the Cambrian

Paul Tafforeau, David J. Bottjer, Eric H. Davidson
2015-01-14

Marine natural products as inhibitors of cystathionine beta-synthase activity

Mary Kay Harper, Tomas Majtan
2015-07-23

Small-molecule kinase inhibitors: an analysis of FDA-approved drugs

Mads H Clausen
2014-06-10

4,5-Di-substituted benzyl-imidazol-2-substituted amines as the structure template for the design and synthesis of reversal agents against P-gp-mediated multidrug resistance breast cancer cells

Larry Ming-Cheung Chow
2014-05-07

The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation

Francisco J. Tejedor, Walter Becker
2014-01-30

Long-range crystalline order in spicules from the calcareous sponge Paraleucilla magna (Porifera, Calcarea).

Radovan Borojevic, André Rossi, Braulio S Archanjo, Michelle Klautau
2013-12-23

Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection

Najma Rachidi, Eric Prina, Cedric Notredame, Laurent Meijer
2013-12-23

cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease

Gaetan Chicanne, Laurent Meijer
2013-01-01

Benzylidene 2-aminoimidazolones derivatives: synthesis and in vitro evaluation of anti-tumor carcinoma activity
2013-11-01

2-Aminoimidazoles in medicinal chemistry
2013-04-23

Design, synthesis and spectroscopic characterisation of a focused library based on the polyandrocarpamine natural product scaffold

Rohan A. Davis, Colleen Nelson
2012-11-08

Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B

Panagis Filippakopoulos, Meera Soundararajan, Jonathan M Elkins, Laurence Pearl, Stefan Knapp, Florent Delhommel, Ralf Schmid, Tania Tahtouh, Emilie Durieu, François Carreaux, Jean-Pierre Bazureau, Donald C. Lo, Laurent Meijer
2012-06-01

Assessing calcareous sponges and their associated bacteria for the discovery of new bioactive natural products

Mélanie Roué, Isabelle Domart-Coulon
2011-05-26

Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing

Panagis Filippakopoulos, Meera Soundararajan, Oleg Fedorov, Yasushi Ogawa, Andreas Eisenreich, Andreas Eisenreich, Stefan Knapp, Tania Tahtouh, François Carreaux, Jean-Pierre Bazureau, Olivier Lozach, Ursula Rauch, Laurent Meijer
2011-12-08

An efficient approach to dispacamide A and its derivatives

Ludovic Paquin
2010-10-28

Structure and synthesis of 2-aminoimidazole alkaloids from Leucetta and Clathrina sponges
2010-06-30

Cellular localization of clathridimine, an antimicrobial 2-aminoimidazole alkaloid produced by the Mediterranean calcareous sponge Clathrina clathrus

Mélanie Roué, Isabelle Domart-Coulon
2009-01-01

Preparation of hymenialdisine, analogues and their evaluation as kinase inhibitors
2009-05-19

Aplysinopsins--marine indole alkaloids: chemistry, bioactivity and ecological significance

Jordan Zjawiony
2009-02

A microwave-assisted stereoselective synthesis of polyandrocarpamines A and B

Carleen Cullinane
2008-01

A quantitative analysis of kinase inhibitor selectivity
2007-03-12

Purification of CK1 by affinity chromatography on immobilised axin.

Laurent Meijer
2005-12-01

A new glycociamidine ring precursor: syntheses of (Z)-hymenialdisine, (Z)-2-debromohymenialdisine, and (+/-)-endo-2-debromohymenialdisine
2004-03-11

Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localisation and selective inhibitors

Conrad Kunick, Pietro Alano, Christian Doerig, Laurent Meijer
2004-08-01

A likely biogenetic gateway linking 2-aminoimidazolinone metabolites of sponges to proline: spontaneous oxidative conversion of the pyrrole-proline-guanidine pseudo-peptide to dispacamide A.

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