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Molecular Insights and Functional Implication of LRRK2 Dimerization.

author

Luigi Bubacco

published in: Advances in neurobiology

date of publication: 2017-01-01

Cites articles 60

Date

Title

Authors

2015-05-01

Regulation of RAF protein kinases in ERK signalling

Hugo Lavoie
2015-09-22

LRRK2 autophosphorylation enhances its GTPase activity

Andrew B. West
2015-08-26

Conformational heterogeneity of the Roc domains in C. tepidum Roc-COR and implications for human LRRK2 Parkinson mutations

Johann P Klare, Alfred Wittinghofer
2015-01-01

Revisiting the Roco G-protein cycle

Alfred Wittinghofer
2015-01-03

The mouse/human cross-species heterodimer of leucine-rich repeat kinase 2: possible significance in the transgenic model mouse of Parkinson's disease

Tatsunori Maekawa
2015-01-01

Inhibitors of leucine-rich repeat kinase 2 (LRRK2): progress and promise for the treatment of Parkinson's disease
2015-02-01

Effect of selective LRRK2 kinase inhibition on nonhuman primate lung

Søren Warming, Merone Roose-Girma
2015-05-05

LRRK2 dephosphorylation increases its ubiquitination

Jing Zhao
2014-06-26

Genetic, structural, and molecular insights into the function of ras of complex proteins domains

Patrick A. Lewis
2014-05-05

Structural biology of the LRRK2 GTPase and kinase domains: implications for regulation
2014-03-18

Parkinson disease-associated mutation R1441H in LRRK2 prolongs the "active state" of its GTPase domain

Mark R Cookson, Christopher Burlak
2014

LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex

Elisa Greggio, Elisa Belluzzi, Francesco Longo, Ludovico Arcuri, Martina Gabrielli, Isabella Russo, Luca Murru, Giovanni Piccoli, Carlo Sala, Ernesto Fedele, Luigi Bubacco, Michela Matteoli
2014-06-18

Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution

David N Hauser, Patrick A. Lewis, Mark R Cookson, Alexandra Beilina, Adamantios Mamais, Rina Bandopadhyay
2014-03-27

Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy
2014-03-18

Mechanism and consequences of RAF kinase activation by small-molecule inhibitors
2014

Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7

Alexandra Beilina, Mark R Cookson, Alice Kaganovich, Adamantios Mamais
2014-05-09

The Parkinson disease-linked LRRK2 protein mutation I2020T stabilizes an active state conformation leading to increased kinase activity
2014-02-18

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

Elisa Greggio, Veerle Baekelandt, Jean-Marc Taymans, Evy Lobbestael, Maciej Olszewski, David N Hauser, Andres Lozano, Mark R Cookson, Alice Kaganovich, Alexandra Beilina, Michele T M Hu, Daniela Berg
2013-08-01

Inhibition of LRRK2 kinase activity stimulates macroautophagy

Claudia Manzoni, Marc P M Soutar, Paola Giunti, Sharon Tooze, Patrick A. Lewis, Adamantios Mamais, Rina Bandopadhyay, Helene Plun-Favreau
2013-10-15

Protein kinase D-mediated phosphorylation at Ser99 regulates localization of p21-activated kinase 4
2013-11-15

Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle

Mathieu Bollen, Monique Beullens, Veerle Baekelandt, Jean-Marc Taymans, Mark R Cookson, Aleksandra Beylina, Evy Lobbestael, Jing Zhao
2013-01-11

Dominant-negative effects of LRRK2 heterodimers: a possible mechanism of neurodegeneration in Parkinson's disease caused by LRRK2 I2020T mutation
2012-06-26

Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations

Alfred Wittinghofer
2012

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers

Elisa Greggio, Veerle Baekelandt, Alexandra Beilina, Elisa Belluzzi, Jean-Marc Taymans, Evy Lobbestael, Ivan Mičetić, Luigi Bubacco, Mark R Cookson, Marc De Maeyer, Renée Vancraenenbroeck
2012-12-01

Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.

Donald S Kirkpatrick
2012-08-15

The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation

David N Hauser, Mark R Cookson, Aleksandra Beylina, Alice Kaganovich
2012-02-01

Re-examination of the dimerization state of leucine-rich repeat kinase 2: predominance of the monomeric form

Genta Ito
2012-06-05

Number and brightness analysis of LRRK2 oligomerization in live cells

Enrico Gratton, Michelle A Digman
2012-01-09

Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway
2011-01

Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

Elisa Greggio, Veerle Baekelandt, Jean-Marc Taymans, Mark R Cookson, Marc De Maeyer, Evy Lobbestael, Renée Vancraenenbroeck
2011-11-11

LRRK2 Parkinson disease mutations enhance its microtubule association

William T Dauer
2011-03-01

Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease

Qingjun Wang

Article - wd:Q51082151

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