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Dilated cardiomyopathy myosin mutants have reduced force-generating capacity.

author

Michael A. Geeves

published in: Journal of Biological Chemistry

date of publication: 2018-04-17

language: English

main subject: dilated cardiomyopathy

Cites articles 57

Date

Title

Authors

2017-12-01

Regulation of Contraction by the Thick Filaments in Skeletal Muscle
2017-09-01

Dilated Cardiomyopathy: Genetic Determinants and Mechanisms.
2017-07-17

Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light

James A Spudich
2017-05-08

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations
2017-03-01

Modeling the Actin.myosin ATPase Cross-Bridge Cycle for Skeletal and Cardiac Muscle Myosin Isoforms

Michael A. Geeves, Boban Stojanović
2016-12-01

Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human β-Cardiac Myosin.
2016-03-04

The Most Prevalent Freeman-Sheldon Syndrome Mutations in the Embryonic Myosin Motor Share Functional Defects

Michael A. Geeves
2015-10-09

Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function

Ariana Combs, Stephen Langer, Shirley Sutton, Michael A. Geeves, James A Spudich
2015-08-04

Harmonic force spectroscopy measures load-dependent kinetics of individual human β-cardiac myosin molecules

Christian L. Vestergaard, Kim I Mortensen, Jongmin Sung, Henrik Flyvbjerg
2015-04-30

Ensemble force changes that result from human cardiac myosin mutations and a small-molecule effector

Tural Aksel
2015-02-01

The myosin mesa and a possible unifying hypothesis for the molecular basis of human hypertrophic cardiomyopathy
2014-12-01

Inherent force-dependent properties of β-cardiac myosin contribute to the force-velocity relationship of cardiac muscle

Michael J Greenberg
2014-10-16

A new mechanokinetic model for muscle contraction, where force and movement are triggered by phosphate release
2014-08-25

Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca(2+)-sensitivity in the pathogenesis of cardiomyopathy
2013-12-16

The hypertrophic cardiomyopathy myosin mutation R453C alters ATP binding and hydrolysis of human cardiac β-myosin

Leslie Leinwand, Michael A. Geeves
2013-08-01

The superfast human extraocular myosin is kinetically distinct from the fast skeletal IIa, IIb, and IId isoforms

Leslie Leinwand, Michael A. Geeves
2013-06-24

Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human β-cardiac myosin motor function

Jongmin Sung, Leslie Leinwand
2013-03-27

Familial dilated cardiomyopathy mutations uncouple troponin I phosphorylation from changes in myofibrillar Ca²⁺ sensitivity

Douglas G. Ward, Sachio Morimoto
2012-07-09

The mutations associated with dilated cardiomyopathy
2012-02-16

Identification of functional differences between recombinant human α and β cardiac myosin motors

Michael A. Geeves, Leslie Leinwand
2010-11-01

Clinical and genetic issues in dilated cardiomyopathy: a review for genetics professionals
2010-07-17

Myo1c mutations associated with hearing loss cause defects in the interaction with nucleotide and actin

Michael A. Geeves
2010-01-01

Structural and functional insights into the Myosin motor mechanism

Anne Houdusse-Juillé
2010-05-01

The genetics of dilated cardiomyopathy
2009-12-01

A peptide tag system for facile purification and single-molecule immobilization

Shohei Koide
2008-05

Coding sequence mutations identified in MYH7, TNNT2, SCN5A, CSRP3, LBD3, and TCAP from 313 patients with familial or idiopathic dilated cardiomyopathy
2008-05-13

Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backbone
2007-08-28

Kinetic analysis of the slow skeletal myosin MHC-1 isoform from bovine masseter muscle

Michael A. Geeves
2007-03-09

Hypertrophic and dilated cardiomyopathy mutations differentially affect the molecular force generation of mouse alpha-cardiac myosin in the laser trap assay

Jeffrey Moore, Jonathan G Seidman
2006-09-18

Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function

Ferhaan Ahmad, Martin J Lohse, Jonathan G Seidman, Christine E. Seidman, David C. Conner, Joachim P Schmitt, Ulrike Mende
2005-09-01

Sarcomeric protein mutations in dilated cardiomyopathy
2005-01-01

The molecular mechanism of muscle contraction

Michael A. Geeves, Kenneth Holmes

Article - wd:Q52318721

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