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Ras enhances TGF-β signaling by decreasing cellular protein levels of its type II receptor negative regulator SPSB1.

автор

Richard Simpson

Hong-Jian Zhu

опубликовано в: Cell Communication and Signaling

дата публикации: 2018-03-13

Cites articles 49

Дата

Заголовок

Авторы

2018-02-02

Genetic status of KRAS influences Transforming Growth Factor-beta (TGF-β) signaling: An insight into Neuropilin-1 (NRP1) mediated tumorigenesis.

Sneha Vivekanandhan, Debabrata Mukhopadhyay
2015-06-01

SPSB1, a Novel Negative Regulator of the Transforming Growth Factor-β Signaling Pathway Targeting the Type II Receptor

Rodney B Luwor
2014-08-08

Ras promotes transforming growth factor-β (TGF-β)-induced epithelial-mesenchymal transition via a leukotriene B4 receptor-2-linked cascade in mammary epithelial cells
2011-10-01

Elucidating the mechanism of regulation of transforming growth factor β Type II receptor expression in human lung cancer cell lines
2011-08-29

TLR regulation of SPSB1 controls inducible nitric oxide synthase induction

Akshay A D'Cruz, Seth L Masters, Marnie Blewitt, Raymond Norton
2010-07-06

Proto-oncogenic H-Ras, K-Ras, and N-Ras are involved in muscle differentiation via phosphatidylinositol 3-kinase
2010-07-05

The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation

Lukasz Kedzierski, Jeffrey J Babon, Shenggen Yao, Bernadette M Saunders, Seth L Masters, Raymond Norton
2010-08-20

Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4

Panagis Filippakopoulos, Pavel Savitsky, Timothy Sharpe, Shenggen Yao, Raymond Norton
2010-02-01

Extracellular remodelling during oncogenic Ras-induced epithelial-mesenchymal transition facilitates MDCK cell migration.

Rommel A. Mathias, Richard Simpson, Robert L Moritz, Eugene Kapp
2009-06-01

Secretome-based proteomic profiling of Ras-transformed MDCK cells reveals extracellular modulators of epithelial-mesenchymal transition

Rommel A. Mathias, Richard Simpson, Robert L Moritz, Eugene Kapp
2009-02-27

SPRY domain-containing SOCS box protein 2: crystal structure and residues critical for protein binding

Seth L Masters, Shenggen Yao, Raymond Norton
2008-03-16

Tumour maintenance is mediated by eNOS.

David Kashatus, Kian-Huat Lim
2006-12-01

Structural basis for protein recognition by B30.2/SPRY domains

Jae-Sung Woo
2005-12-20

The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues

Kirsten Palmer, Brian J. Smith, Nicos A. Nicola, Seth L Masters, Shenggen Yao, Jeffrey J Babon, Raymond Norton
2005-02-15

The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway
2004-01-01

Molecular aspects of epithelial cell plasticity: implications for local tumor invasion and metastasis

Josef Gotzmann, Mario Mikula, Wolfgang Mikulits, Roland Foisner, Andreas Eger, Rolf Schulte-Hermann, Hartmut Beug
2003-06-01

Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos

Melinda L Tursky
2003-01

Targeting RAS signalling pathways in cancer therapy

Julian Downward
2003-08-01

Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis

Martin Jechlinger
2003-06-17

Cross-talk between ERK MAP kinase and Smad signaling pathways enhances TGF-beta-dependent responses in human mesangial cells
2002-11-14

Epithelial to mesenchymal transition in Madin-Darby canine kidney cells is accompanied by down-regulation of Smad3 expression, leading to resistance to transforming growth factor-beta-induced growth arrest

Caroline S. Hill, Julian Downward, Francisco José Nicolás
2002-08-01

Oncogenic Ras/Her-2 mediate hyperproliferation of polarized epithelial cells in 3D cultures and rapid tumor growth via the PI3K pathway

Julian Downward, Elzbieta Janda
2002-01-14

Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways

Julian Downward, Elzbieta Janda
2002-07-01

Metastasis is driven by sequential elevation of H-ras and Smad2 levels.

Rosemary J Akhurst
2001-11-01

Regulation of transforming growth factor-beta signaling
2001-11-01

TGF-beta signaling in cancer--a double-edged sword
2001-10

TGF-beta signaling in tumor suppression and cancer progression
2001-04-01

Analysis of the transcriptional program induced by Raf in epithelial cells

Julian Downward, Almut Schulze
2000-10-01

Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells

Caroline S. Hill, Julian Downward, Elzbieta Janda, Almut Schulze
2000-08-01

Role of the IkappaB kinase complex in oncogenic Ras- and Raf-mediated transformation of rat liver epithelial cells
1999-09-01

Genetic approaches to TGFbeta signaling pathways
1999-11-01

Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells

Жоан Масаге

Статья - wd:Q55013837

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