Inventaire - أصدقاؤك ومجتمعاتك هم أفضل مكتبة لك

Structural Determinants of the Prion Protein N-Terminus and Its Adducts with Copper Ions

الكاتب

Liliana Quintanar

Giulia Rossetti

Paolo Carloni

منشور في: International Journal of Molecular Sciences

تاريخ النشر: 2018-12-20

اللغة: الإنجليزية

الموضوع الرئيسي: مركب لاعضوي, بروتين غشائي, بريون, protein interaction domains and motifs

Cites articles 116

Date

العنوان

الكاتبون

2018-02-08

Neuroprotective alpha-cleavage of the human prion protein significantly impacts Cu(ii) coordination at its His111 site.
2018-10-25

Differential modulation of NMDA and AMPA receptors by cellular prion protein and copper ions

Chris Bladen, Gerald W. Zamponi
2017-08-02

Structural Modeling of Human Prion Protein's Point Mutations

Giulia Rossetti, Paolo Carloni
2017-07-31

Copper- and Zinc-Promoted Interdomain Structure in the Prion Protein: A Mechanism for Autoinhibition of the Neurotoxic N-Terminus
2016-03-01

Spectroscopic and Theoretical Study of Cu(I) Binding to His111 in the Human Prion Protein Fragment 106-115

Marco C Miotto, Rafael Grande-Aztatzi, Claudio O. Fernandez, Alberto Vela
2016-05-24

Interaction between Prion Protein's Copper-Bound Octarepeat Domain and a Charged C-Terminal Pocket Suggests a Mechanism for N-Terminal Regulation

M. Jake Pushie
2016-10-05

Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity

Luis Fonseca-Ornelas, Giulia Rossetti, Paolo Carloni, Claudio O. Fernandez, Débora Foguel, Ira Milosevic, Salvador Ventura, Tiago Fleming Outeiro, Anna Villar-Piqué, Markus Zweckstetter
2015-02-04

Prion protein and copper cooperatively protect neurons by modulating NMDA receptor through S-nitrosylation

Giuseppe Legname, Federico Benetti
2015-10-20

The non-octarepeat copper binding site of the prion protein is a key regulator of prion conversion

Gabriele Giachin, Giulia Salzano, Federico Benetti, Alessandro Arcovito, Stefano Della Longa, Paola D'Angelo
2014-03-01

PrP overdrive: does inhibition of α-cleavage contribute to PrP(C) toxicity and prion disease?
2014-08-28

Cellular prion protein and NMDA receptor modulation: protecting against excitotoxicity
2013-01-15

Structural models for Cu(II) bound to the fragment 92-96 of the human prion protein

Rafael Grande-Aztatzi, Alberto Vela
2013-01-03

Zinc drives a tertiary fold in the prion protein with familial disease mutation sites at the interface
2013-04-27

Flotillin-1 mediates PrPc endocytosis in the cultured cells during Cu²⁺ stimulation through molecular interaction

Qi Shi, Xiao-Ping Dong
2013-01-01

Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity

Cassandra Terry, Tiernan T O'Malley, Jonathan Wadsworth, Helen Saibil, John Collinge
2013-01-01

Computational studies on the prion protein

Salvatore Bongarzone, Giulia Rossetti, Paolo Carloni
2013-11-18

A new paradigm for enzymatic control of α-cleavage and β-cleavage of the prion protein
2013-11-01

Role of Prion Disease-Linked Mutations in the Intrinsically Disordered N-Terminal Domain of the Prion Protein

Giuseppe Legname, Gabriele Giachin, Sandipan Mohanty, Giulia Rossetti, Paolo Carloni, Xiaojing Cong
2012-03

The prion protein unstructured N-terminal region is a broad-spectrum molecular sensor with diverse and contrasting potential functions
2012-01-17

Aβ neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors

Gerald W. Zamponi
2012-02-06

Copper-dependent regulation of NMDA receptors by cellular prion protein: implications for neurodegenerative disorders

Gerald W. Zamponi
2012-04-04

High-resolution structure of infectious prion protein: the final frontier
2012-07-27

Effects of the pathological Q212P mutation on human prion protein non-octarepeat copper-binding site.

Paola D'Angelo, Alessandro Arcovito, Giovanni Chillemi, Gabriele Giachin, Giuseppe Legname, Andrea Zitolo, Stefano Della Longa
2012-05-04

The Rich Electrochemistry and Redox Reactions of the Copper Sites in the Cellular Prion Protein
2012-05-15

Proteolytic processing of the prion protein in health and disease

Hermann Altmeppen
2011-01-24

Spectroscopic and electronic structure studies of copper(II) binding to His111 in the human prion protein fragment 106-115: evaluating the role of protons and methionine residues

Rafael Grande-Aztatzi, Alberto Vela
2011-03-01

Discordant and chameleon sequences: their distribution and implications for amyloidogenicity
2011-05-17

Copper(II)-induced secondary structure changes and reduced folding stability of the prion protein
2011-01-01

Prion protein and its conformational conversion: a structural perspective
2011-08

Common Structural Traits across Pathogenic Mutants of the Human Prion Protein and Their Implications for Familial Prion Diseases

Giulia Rossetti, Giuseppe Legname, Paolo Carloni, Rocco Caliandro, Xiaojing Cong
2011-07-18

Copper redox cycling in the prion protein depends critically on binding mode
2011-09-07

Copper alters aggregation behavior of prion protein and induces novel interactions between its N- and C-terminal regions

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