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L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction

author

Ekaitz Errasti-Murugarren

Joana Fort

Paola Bartoccioni

Lucía Díaz

Els Pardon

Meritxell Espino-Guarch

Antonio Zorzano

Jan Steyaert

1964 -

published in: Nature Communications

date of publication: 2019-04-18

language: English

Cites articles 67

Date

Title

Authors

2019-01-29

Functional characterization of the alanine-serine-cysteine exchanger of Carnobacterium sp AT7

Paola Bartoccioni, Joana Fort, Ekaitz Errasti-Murugarren
2018-04-02

Cooperation of Antiporter LAT2/CD98hc with Uniporter TAT1 for Renal Reabsorption of Neutral Amino Acids

Clara Vilches, Susanna Bodoy, Simone Camargo, Miguel López de Heredia, Esther Prat, Aida Ormazabal, Rafael Artuch, Antonio Zorzano, Francois Verrey, Virginia Nunes, Manuel Palacín
2018-01-22

Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in Age-Related Hearing Loss.

Mara Dierssen Sotos, Meritxell Espino-Guarch, Silvia Murillo-Cuesta, Ekaitz Errasti-Murugarren, Adelaida M. Celaya, Giorgia Girotto, Clara Vilches, Susanna Bodoy, Paolo Gasparini, Virginia Nunes
2018-02-07

Structural basis for amino acid transport by the CAT family of SLC7 transporters.

Simon Newstead, Katharina E J Jungnickel, Joanne L. Parker
2018-03-20

Effects of Mutations and Ligands on the Thermostability of the l-Arginine/Agmatine Antiporter AdiC and Deduced Insights into Ligand-Binding of Human l-Type Amino Acid Transporters

Claire Colas
2017-07-12

Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs

Michele Galluccio, Maria Koyioni, Luca Palazzolo, Leonardo Pisani, Lara Console, Angelo Carotti, Marco Catto
2017-10-16

Administering xCT Inhibitors Based on Circadian Clock Improves Antitumor Effects

Yasuhiro Tsuji
2017-02-01

Polder maps: improving OMIT maps by excluding bulk solvent

Nigel W Moriarty, Paul D. Adams, Pavel V Afonine
2016-03-05

Amino Acid Transport Associated to Cluster of Differentiation 98 Heavy Chain (CD98hc) Is at the Cross-road of Oxidative Stress and Amino Acid Availability

Laura R de la Ballina, Elena González-Muñoz, Soline Estrach, Chloé C Féral
2016-12-01

Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder

Avner Schlessinger, Kaya Bilguvar, Joseph G Gleeson, Tawfeg Ben-Omran
2016-06-14

A novel Na(+) -Independent alanine-serine-cysteine transporter 1 inhibitor inhibits both influx and efflux of D-Serine

Katsuya Sakimura
2016-01-02

Structure-activity relations of leucine derivatives reveal critical moieties for cellular uptake and activation of mTORC1-mediated signaling

Yoshiyuki Hari, Suguru Okuda
2016-09-03

LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates

Claire Colas, Allen Thomas
2016-08-31

Insights into the molecular basis for substrate binding and specificity of the wild-type L-arginine/agmatine antiporter AdiC.

Vytautas Gapsys
2016-01-01

Crystallization of P-type ATPases by the High Lipid-Detergent (HiLiDe) Method

Kaituo Wang, Pontus Gourdon
2015-05-06

Structural insights into thyroid hormone transport mechanisms of the L-type amino acid transporter 2.

Josef Köhrle
2015-01-01

Structural Symmetry in Membrane Proteins

Lucy R. Forrest
2015-02-04

Trends in thermostability provide information on the nature of substrate, inhibitor, and lipid interactions with mitochondrial carriers

Yang Lee, Jonathan J. Ruprecht, Chancievan Thangaratnarajah, Martin S King, Edmund R.S. Kunji
2015-11-18

Two Na+ Sites Control Conformational Change in a Neurotransmitter Transporter Homolog

Eleonora Margheritis, Silvia Ravera, Lucy R. Forrest, Gary Rudnick
2015-12-03

CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field

David A. Case, Wonpil Im, Charles L Brooks, Vijay Pande
2014-02-10

Structural bases for the interaction and stabilization of the human amino acid transporter LAT2 with its ancillary protein 4F2hc

Elena Álvarez-Marimon, Juan Fernández-Recio
2014-10-05

A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters

Poul Nissen, Joseph A Lyons, Jonathan Javitch, Hideaki Yano
2014-09-29

Conformational cycle and ion-coupling mechanism of the Na+/hydantoin transporter Mhp1.
2014-03-06

Molecular basis of nitrate uptake by the plant nitrate transporter NRT1.1

Joanne L. Parker, Simon Newstead
2014-02-27

A general protocol for the generation of Nanobodies for structural biology

Jan Steyaert, Els Pardon, Søren G. F. Rasmussen, Alexandre Wohlkönig, Serge Muyldermans, Brian Kobilka, Wim G J Hol, Toon Laeremans, Sarah Triest
2014-08-07

CHARMM-GUI Membrane Builder toward realistic biological membrane simulations

Wonpil Im
2014-08-24

CHARMM-GUI PDB manipulator for advanced modeling and simulations of proteins containing nonstandard residues

Kenno Vanommeslaeghe, Alex MacKerell
2013-04-01

The SLC3 and SLC7 families of amino acid transporters
2013-11-04

Functional identification and characterization of sodium binding sites in Na symporters

Edurne Gorraitz
2013-10-22

Arginine oscillation explains Na+ independence in the substrate/product antiporter CaiT

Werner Kühlbrandt
2013-12-10

In vitro Characterization of a small molecule inhibitor of the alanine serine cysteine transporter -1 (SLC7A10).
2013-06-18

Decision making in xia2.

Stephen M Prince

Article - wd:Q64103394

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