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The Metabolomic Signature of Opa1 Deficiency in Rat Primary Cortical Neurons Shows Aspartate/Glutamate Depletion and Phospholipids Remodeling

author

Guillaume Tcherkez

1976 -

Guy Lenaers

1962 -

mű, amelyben megjelent: Scientific Reports

date of publication: 2019-04-15

language: angol

Cites articles 39

Date

Title

Authors

2018-01-01

A Plasma Metabolomic Signature Involving Purine Metabolism in Human Optic Atrophy 1 (OPA1)-Related Disorders

Cinzia Bocca, Marc Ferre, Arnaud Chevrollier, Vincent Procaccio, Pascal Reynier, Guy Lenaers, Patrizia Amati-Bonneau, Christophe Verny
2018-08-01

The Metabolomic Bioenergetic Signature of Opa1-Disrupted Mouse Embryonic Fibroblasts Highlights Aspartate Deficiency

Cinzia Bocca, Vincent Procaccio, Arnaud Chevrollier, Pascal Reynier
2017-05-25

Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence

Mattia Albiero, María Isabel Soriano, Helmut Kern, Maria Conte, Bert Blaauw, Luca Scorrano, Claudio Franceschi, Gian Paolo Fadini
2017-04-04

Autophagy controls the pathogenicity of OPA1 mutations in dominant optic atrophy

Valérie Desquiret-Dumas, Naïg Gueguen, Marc Ferre, Vincent Procaccio, Dominique Bonneau, Guy Lenaers, Pascal Reynier, Arnaud Chevrollier, Patrizia Amati-Bonneau
2017-02-01

Targeted Metabolomics Reveals Early Dominant Optic Atrophy Signature in Optic Nerves of Opa1delTTAG/+ Mice

Dominique Bonneau, Emmanuelle Sarzi, Guillaume Rousseau, Marc Ferre, Arnaud Chevrollier, Valérie Desquiret-Dumas, Naïg Gueguen, Vincent Procaccio, Guy Lenaers, Pascal Reynier, Patrizia Amati-Bonneau, Christophe Verny, Delphine Prunier-Mirebeau
2016-12-01

A neurodegenerative perspective on mitochondrial optic neuropathies

Patrick Yu-Wai-Man
2016-04-25

Loss of functional OPA1 unbalances redox state: implications in dominant optic atrophy pathogenesis

Pascal Reynier, Anne Galinier, Pascale Belenguer
2016-12-20

OPA1 haploinsufficiency induces a BNIP3-dependent decrease in mitophagy in neurons: relevance to Dominant Optic Atrophy

Marie-Christine Miquel, Pascale Belenguer
2016-09-15

The metabolomic signature of Leber's hereditary optic neuropathy reveals endoplasmic reticulum stress.

Naïg Gueguen, Arnaud Chevrollier, Valérie Desquiret-Dumas, Marc Ferre, Cinzia Bocca, Dominique Bonneau, Guy Lenaers, Vincent Procaccio, Pascal Reynier, Patrizia Amati-Bonneau, Christophe Verny, Delphine Prunier-Mirebeau
2015-08-23

OPA1-related disorders: Diversity of clinical expression, modes of inheritance and pathophysiology

Marc Ferre, Emmanuelle Sarzi, Stéphanie Leruez, Arnaud Chevrollier, Valérie Desquiret-Dumas, Naïg Gueguen, Vincent Procaccio, Dominique Bonneau, Guy Lenaers, Pascal Reynier, Delphine Prunier-Mirebeau
2015-10-19

Mitochondrial fusion/fission dynamics in neurodegeneration and neuronal plasticity

Marie-Christine Miquel, Manuel Rojo, Pascale Belenguer
2015-07-01

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

Timothy C Wang, Walter W Chen, David M. Sabatini, Elizaveta Freinkman, Kıvanç Birsoy
2015-07-01

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

Lucas B Sullivan, Elizaveta Freinkman
2015-03-05

Fatty acid trafficking in starved cells: regulation by lipid droplet lipolysis, autophagy, and mitochondrial fusion dynamics

Jennifer Lippincott-Schwartz, Angelika S. Rambold
2014-12-01

Improved locus-specific database for OPA1 mutations allows inclusion of advanced clinical data

Marc Ferre, Arnaud Chevrollier, Dominique Bonneau, Vincent Procaccio, Pascal Reynier, Patrizia Amati-Bonneau, Christophe Verny
2014-10-08

OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand

Mireille Khacho, Ryan J Mailloux, David S Park, Heidi M McBride, Mary-Ellen Harper, Marc Germain
2013-03-29

OPA1 loss of function affects in vitro neuronal maturation

Marie-Christine Miquel, Pascale Belenguer
2013-12-17

Membrane lipid unsaturation as physiological adaptation to animal longevity

Alba Naudí, Mariona Jové, Gustavo Barja, Reinald Pamplona
2012-12-01

The human OPA1delTTAG mutation induces premature age-related systemic neurodegeneration in mouse

Emmanuelle Sarzi, Nathalie Boddaert, Cécile Delettre, Jean-Luc Puel, Pascal Reynier, Guy Lenaers, Valerie Rigau
2012-02-01

Opa1 is essential for retinal ganglion cell synaptic architecture and connectivity

Pete A Williams, Marcela Votruba
2011-12-08

A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics
2011-10-07

Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis

Guillaume Pidoux, Thomas Küntziger, Kjetil Taskén
2011-10-19

The front-end desaturase: structure, function, evolution and biotechnological use.
2010-10-25

OPA1 links human mitochondrial genome maintenance to mtDNA replication and distribution

Patrick Yu-Wai-Man, Patrick F. Chinnery, Guy Lenaers, Valerio Carelli
2010-06-01

Characterization of Ca2+ signalling in postnatal mouse retinal ganglion cells: involvement of OPA1 in Ca2+ clearance

Cedric Viero, Guy Lenaers
2010-09-03

Opa1 deficiency in a mouse model of dominant optic atrophy leads to retinal ganglion cell dendropathy

Marcela Votruba
2009-02-16

Heterozygous mutation of Opa1 in Drosophila shortens lifespan mediated through increased reactive oxygen species production

Taosheng Huang
2009-02-21

OPA1 deficiency associated with increased autophagy in retinal ganglion cells in a murine model of dominant optic atrophy

Douglass Matthew Turnbull, Marcela Votruba
2009-08-24

Phospholipid association is essential for dynamin-related protein Mgm1 to function in mitochondrial membrane fusion

John L. Rubinstein
2009-08-10

Possible role of mitochondrial remodelling on cellular triacylglycerol accumulation
2008-06-01

Hereditary optic neuropathies share a common mitochondrial coupling defect

Marc Ferre, Vincent Procaccio, Pascal Reynier, Patrizia Amati-Bonneau, Christophe Verny
2008-02

OPA1 mutations induce mitochondrial DNA instability and optic atrophy 'plus' phenotypes

Robert Schwarzenbacher, Pasquale Montagna, Dominique Figarella-Branger, Rafael Garesse, Chiara La Morgia, Luisa Iommarini, Guy Lenaers, Maria Lucia Valentino, Michela Rugolo, Maria Liguori, Pascal Reynier, Miguel Angel Martín, Rocco Liguori, Valerio Carelli, Andrea Cossarizza, Carmen Ayuso, Joaquín Arenas, Patrizia Amati-Bonneau, Christophe Verny

Article - wd:Q64115753

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