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Synthesis and biophysical properties of carbamate-locked nucleic acid (LNA) oligonucleotides with potential antisense applications

author

Tom Brown, Sr.

published in: Organic and Biomolecular Chemistry

date of publication: 2019-05-01

Cites articles 34

Date

Title

Authors

2018-04-13

Incorporation of bridged nucleic acids into CRISPR RNAs improves Cas9 endonuclease specificity.

Christopher R Cromwell, Basil P Hubbard, Seong Keun Kim
2018-07-23

Synthesis and biophysical properties of 5'-thio-2',4'-BNA/LNA oligonucleotide,Synthesis and biophysical properties of 5′-thio-2′,4′-BNA/LNA oligonucleotide

Md Ariful Islam
2018-06-27

Synthesis, Affinity for Complementary RNA and DNA, and Enzymatic Stability of Triazole-Linked Locked Nucleic Acids (t-LNAs)

Pawan Kumar, Ysobel R Baker, Afaf Helmy El-Sagheer, Tom Brown, Sr.
2018-09-01

Inotersen: First Global Approval
2018-10-01

Patisiran: First Global Approval
2017-01-18

Molecular Requirements of High-Fidelity Replication-Competent DNA Backbones for Orthogonal Chemical Ligation.

Tom Brown, Sr., Arun Shivalingam
2017-02-27

The chemical evolution of oligonucleotide therapies of clinical utility
2017-02-21

FDA Approval of Nusinersen for Spinal Muscular Atrophy Makes 2016 the Year of Splice Modulating Oligonucleotides

Annemieke Aartsma-Rus
2017-07-24

Synthesis and biological properties of triazole-linked locked nucleic acid

Reka A Haraszti, Jonathan K Watts
2017-07-27

Locked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA.

Tom Brown, Sr., Pawan Kumar
2017-08-21

Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides.
2016-07-19

The Medicinal Chemistry of Therapeutic Oligonucleotides
2016-12-08

FDA Approves Eteplirsen for Duchenne Muscular Dystrophy: The Next Chapter in the Eteplirsen Saga

Annemieke Aartsma-Rus
2014-02-01

Synthesis, biophysical studies and RNA interference activity of RNA having three consecutive amide linkages
2014-06

Amides are excellent mimics of phosphate internucleoside linkages and are well tolerated in short interfering RNAs

Martin Egli
2013-08-01

Clinical pharmacological properties of mipomersen (Kynamro), a second generation antisense inhibitor of apolipoprotein B.
2013-05-02

Clinical trials using antisense oligonucleotides in duchenne muscular dystrophy

Matthew J. Wood
2013-01-01

Design and synthesis of LNA-based mercaptoacetamido-linked nucleoside dimers

Carl Erik Olsen
2013-11-01

Delivery materials for siRNA therapeutics
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RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform
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Click chemistry with DNA.
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Nucleases: diversity of structure, function and mechanism
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LNA-mediated microRNA silencing in non-human primates
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Perspectives on chemistry and therapeutic applications of Locked Nucleic Acid (LNA).
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cis-Tetrahydrofuran-3,4-diol structure as a key skeleton of new protecting groups removable by self-cyclization under oxidative conditions

Kohji Seio
2004-05-01

Sequence-dependent thermodynamic parameters for locked nucleic acid (LNA)-DNA duplex formation

Jason D. Kahn
2003-09-01

Synthesis and properties of a novel bridged nucleic acid with a P3' --> N5' phosphoramidate linkage, 5'-amino-2',4'-BNA

Osamu Nakagawa
2002-05-01

Design of antisense oligonucleotides stabilized by locked nucleic acids

Eliza Wyszko
2002-05-01

Locked nucleic acid (LNA) recognition of RNA: NMR solution structures of LNA:RNA hybrids

Michael Petersen, Jesper Wengel
2002-03-01

Oligodeoxynucleotides containing amide-linked LNA-type dinucleotides: synthesis and high-affinity nucleic acid hybridization
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A simplified and efficient route to 2'-O, 4'-C-methylene-linked bicyclic ribonucleosides (locked nucleic acid).
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The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes

Article - wd:Q64443413

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