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Uncovering the Genetic Architecture of Major Depression

yazar

Andrew McIntosh

Cathryn Lewis

Patrick F. Sullivan

yayınlandığı: Neuron

yayımlanma tarihi: 2019-04-01

dil: İngilizce

Cites articles 79

Date

Başlık

Yazarlar

2019-04-01

Genetics of response to cognitive behavior therapy in adults with major depression: a preliminary report

Samir El Alaoui, Robert Karlsson, Christian Rück, Catharina Lavebratt, Patrick F. Sullivan
2019-06-01

Using genetics to understand the causal influence of higher BMI on depression

Rachel M Freathy, Michael N Weedon, Cathryn Lewis, Tim Frayling, Elina Hyppönen
2019-01-31

Genome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with GENDEP

Eleanor Wigmore, Toni-Kim Clarke, Cathryn Lewis, Mark J Adams, Archie I Campbell, Jude Gibson, Pippa A Thomson, Caroline Hayward, Blair H. Smith, Sandosh Padmanabhan, Kristin K Nicodemus, Andrew McIntosh, Ian Deary, Lynne J Hocking, Jonathan D Hafferty, Lynsey S Hall, David J. Porteous, David M Howard, Yanni Zeng, Manuel Mattheisen
2019-02-26

How much is spent on mental health research: developing a system for categorising grant funding in the UK
2019-03-08

No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples

Emma C Johnson, Patrick F. Sullivan
2019-03-01

Defining the Genetic, Genomic, Cellular, and Diagnostic Architectures of Psychiatric Disorders

Daniel Geschwind, Patrick F. Sullivan
2019-03-13

Genome-wide Burden of Rare Short Deletions Is Enriched in Major Depressive Disorder in Four Cohorts

James Rucker, Simone de Jong, Eco de Geus, Cathryn Lewis, Henriette N Buttenschøn, Margarita Rivera, Gerome Breen, Dorret Boomsma, Brenda Penninx, Peter McGuffin, Abdel Abdellaoui, Michele T Pato, Johannes H Smit, Douglas F Levinson, James B Potash, Myrna M. Weissman, Jouke-Jan Hottenga, Alan R. Sanders, Martin Preisig, Marcella Rietschel, Ole Mors, Rudolf Uher, Nick Craddock
2018-01-10

Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank

Lynsey S Hall, Mark J Adams, Saskia P. Hagenaars, Jude Gibson, Caroline Hayward, David J. Porteous, Andrew McIntosh, Aleix Soler, Toni-Kim Clarke, David M Howard, Thibaud S Boutin, Ian Deary, Pippa A Thomson, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC), Eleanor Wigmore, Yanni Zeng, Ana Maria Fernandez-Pujals, Generation Scotland
2018-01-22

Prediction of inherited genomic susceptibility to 20 common cancer types by a supervised machine-learning method.

Sung-Hou Kim
2018-03-26

Using data linkage to electronic patient records to assess the validity of selected mental health diagnoses in English Hospital Episode Statistics (HES)

Katrina Alice Southworth Davis, Robert Stewart, Cathie Sudlow
2018-04-16

Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways

Mark J Adams, Cathryn Lewis, Daniel J. Smith, Chris Haley, Andrew McIntosh, David M Howard, Masoud Shirali, Toni-Kim Clarke, Riccardo E Marioni, Jonathan R I Coleman, Clara Alloza, Xueyi Shen, Saskia P. Hagenaars, Gerome Breen, Ian Deary, Patrick F. Sullivan, 23andMe Research Team, Miruna C Barbu, Jude Gibson, Eleanor Wigmore, Joey Ward
2018-04-26

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.,Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Naomi R. Wray, Jakob Grove, Hamdi Mbarek, Eco de Geus, Patrick F Sullivan, André Uitterlinden, Glyn Lewis, Na Cai, Paola Giusti-Rodríguez, Margarita Rivera, Alexander Viktorin, Rick Jansen, Eske M Derks, Lili Milani, Daniel J. Smith, Thomas F. Hansen, Henriette N Buttenschøn, Rudolf Uher, Danielle Posthuma, Michael C O'Donovan, Cathryn Lewis, Sven Cichon, Gerome Breen, Ian Deary, Katherine E. Tansey, David A Hinds, Dale R Nyholt, Bradley T Webb, Julia Kraft, Stefan Kloiber, Jian Yang, Baptiste Couvy-Duchesne, Sara Mostafavi, Penelope A. Lind, Esben Agerbo, Andrew McIntosh, Jonathan Mill, Andres Metspalu, Tõnu Esko, Ian B Hickie, Isaac Kohane, Enrico Domenici, Christel M Middeldorp, Gregory E. Crawford, Franziska Degenhardt, Engilbert Sigurdsson, Valentina Escott-Price, Thomas Werge, Merete Nordentoft, Peter M. Visscher, Hreinn Stefansson, Marcella Rietschel, Gonneke Willemsen, Dorret Boomsma, Kenneth Kendler, Grant W. Montgomery, Jonathan Marchini, Kári Stefánsson, Myrna M. Weissman, Jouke-Jan Hottenga, Andrew C. Heath, Zoltán Kutalik, Bertram Müller-Myhsok, Evelin Mihailov, Brenda Penninx, Henning Tiemeier, Jordan W Smoller, Preben Bo Mortensen, Alexander Teumer, Peter McGuffin, Fulai Jin, Erik Pettersson, Per Qvist, Tracy M Air, Wouter J Peyrot, Nese Direk, Donald J. MacIntyre, Jesper Krogh, Eilis Hannon, Maciej Trzaskowski, Scott D Gordon, Jane H Christensen, Enrique Castelao, Divya Mehta, Jonas Bybjerg-Grauholm, Toni-Kim Clarke, Lucía Colodro-Conde, Michel G. Nivard, Stephan Ripke, Nancy Pedersen, Martin Preisig, Anders D. Børglum, Patrik K E Magnusson, Julien Bryois, Volker Arolt, Conor Dolan, Abdel Abdellaoui, Yuri Milaneschi, Pippa A Thomson, Per Hoffmann, Thorgeir E. Thorgeirsson, Stephanie H Witt, Nick Martin, Markus M Nöthen, Thomas G. Schulze, Bernhard Baune, Douglas F Levinson, Shaun M Purcell, James B Potash, Hans J Grabe, Roy H Perlis, Johannes H Smit, Enda M Byrne, Mark J Adams, Till F.M. Andlauer, Tim B. Bigdeli, Andreas J Forstner, Fernando S Goes, David M Hougaard, Patrick Mcgrath, Muredach P. Reilly, Steven P Hamilton, Ashley R Winslow, Brien P. Riley, Stacy Steinberg, Nick Craddock, Susanne Lucae, Elisabeth Binder, Stefan Herms, Stanley I Shyn, Jens Treutlein, Manuel Mattheisen, Silviu-Alin Bacanu, Marie Bækvad-Hansen, Aartjan T F Beekman, Erin C Dunn, Thalia C Eley, Hilary K Finucane, Lynsey S Hall, Christine Søholm Hansen, Georg Homuth, Marcus Ising, Eric Jorgenson, Warren W. Kretzschmar, Dean F. MacKinnon, Francis Mondimore, Niamh Mullins, Matthias Nauck, Hogni Oskarsson, Jodie N Painter, Carsten Bøcker Pedersen, Marianne Giørtz Pedersen, Roseann E Peterson, Giorgio Pistis, Saira Saeed Mirza, Robert A Schoevers, Eva C. Schulte, Grant Sinnamon, Fabian Streit, Jana Strohmaier, Matthew Traylor, Vassily Vladimirovich Trubetskoy, Daniel Umbricht, Sandra Van der Auwera, Albert M van Hemert, Shantel Marie Weinsheimer, Klaus Berger, Udo Dannlowski, J Raymond DePaulo, Katharina Domschke, Caroline Hayward, Pamela A F Madden, Ole Mors, Sara A Paciga, David J. Porteous, Catherine Schaefer, Henry Völzke, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC), Hassan S Dashti, Wesley K Thompson
2018-04-28

Machine learning in schizophrenia genomics, a case-control study using 5,090 exomes

Yannis Trakadis
2018-05-21

Genetic identification of brain cell types underlying schizophrenia

Nathan Skene, Trygve E. Bakken, Gerome Breen, Héléna Gaspar, Paola Giusti-Rodríguez, Michael C O'Donovan, Michael Owen, Antonio F Pardiñas, Jesper Ryge, James Walters, Sten Linnarsson, Ed S Lein, Jens Hjerling-Leffler, Jeremy A Miller, Rebecca D Hodge, Ana Belén Muñoz-Manchado, Patrick F Sullivan, Julien Bryois, James J. Crowley, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC)
2018-06-25

Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways

Sven Stringer, Christiaan de Leeuw, Jeanne E. Savage, Anke R Hammerschlag, Nathan Skene, Henning Tiemeier, Sten Linnarsson, Jens Hjerling-Leffler, Tinca Polderman, Patrick F Sullivan, Danielle Posthuma, Ana Belén Muñoz-Manchado, Julien Bryois, 23andMe Research Team
2018-04-03

Mental health in UK Biobank: development, implementation and results from an online questionnaire completed by 157 366 participants.

Katrina Alice Southworth Davis, Jonathan R I Coleman, Gerome Breen, Breda Cullen, Jo Holliday, Louise Howard, Andrew McIntosh, Daniel J. Smith, Cathie Sudlow, Stanley Zammit, Matthew Hotopf, Elaine Fox, Mark J Adams, Robert Pearsall, Joey Ward
2018-09

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

Eric Lander, Mark D Chaffin, Pradeep Natarajan, Sekar Kathiresan, Mary E Haas, Carolina Roselli, Steven A Lubitz, Patrick T Ellinor, Seung-Hoan Choi, Krishna G Aragam
2018-07

Association of Whole-Genome and NETRIN1 Signaling Pathway–Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank

Mandy Johnstone, Till F.M. Andlauer, Simon R Cox, Rick Jansen, Hamdi Mbarek, Jakob Grove, Danielle Posthuma, Baptiste Couvy-Duchesne, Sara Mostafavi, Stefan Kloiber, Bradley T Webb, Andres Metspalu, Tõnu Esko, Lili Milani, Isaac Kohane, Per Qvist, Jonathan R I Coleman, Paul F. O'Reilly, Penelope A. Lind, Alexander Viktorin, Eske M Derks, Enrico Domenici, Gregory E. Crawford, Thomas F. Hansen, Christel M Middeldorp, Esben Agerbo, Franziska Degenhardt, Margarita Rivera, Engilbert Sigurdsson, Dale R Nyholt, Valentina Escott-Price, Thomas Werge, Merete Nordentoft, Peter M. Visscher, Hreinn Stefansson, Marcella Rietschel, Gonneke Willemsen, Kenneth Kendler, Grant W. Montgomery, Jonathan Marchini, Kári Stefánsson, Myrna M. Weissman, Dorret Boomsma, Jouke-Jan Hottenga, Andrew C. Heath, Zoltán Kutalik, Bertram Müller-Myhsok, Evelin Mihailov, Cathryn Lewis, Naomi R. Wray, Henning Tiemeier, Jordan W Smoller, Preben Bo Mortensen, Alexander Teumer, Peter McGuffin, Gerome Breen, Julien Bryois, Stephan Ripke, Volker Arolt, Nancy Pedersen, Conor Dolan, Abdel Abdellaoui, Yuri Milaneschi, Ian Deary, Pippa A Thomson, Douglas F Levinson, Scott D Gordon, Thomas G. Schulze, Nick Martin, James B Potash, Hans J Grabe, Roy H Perlis, Johannes H Smit, Enda M Byrne, Tim B. Bigdeli, Andreas J Forstner, Fernando S Goes, David M Hougaard, Patrick Mcgrath, Steven P Hamilton, Michael C O'Donovan, Anders D. Børglum, Michel G. Nivard, Stephen M Lawrie, Tracy M Air, Henriette N Buttenschøn, Per Hoffmann, Donald J. MacIntyre, Sarah E. Medland, Wouter J Peyrot, Daniel J. Smith, Katherine E. Tansey, Thorgeir E. Thorgeirsson, André Uitterlinden, Stephanie H Witt, Patrik K E Magnusson, Markus M Nöthen, Patrick F Sullivan, Nicholas A Furlotte, David A Hinds, Nadia K Litterman, Carrie A.M. Northover, Brien P. Riley, Stacy Steinberg, Nick Craddock, Susanne Lucae, Martin Preisig, Elisabeth Binder, Stefan Herms, Stanley I Shyn, Jens Treutlein, Joyce Lok-Tung Wai, Manuel Mattheisen, Silviu-Alin Bacanu, Marie Bækvad-Hansen, Aartjan T F Beekman, Erin C Dunn, Thalia C Eley, Hilary K Finucane, Lynsey S Hall, Christine Søholm Hansen, Georg Homuth, Marcus Ising, Eric Jorgenson, Warren W. Kretzschmar, Dean F. MacKinnon, Francis Mondimore, Niamh Mullins, Matthias Nauck, Hogni Oskarsson, Jodie N Painter, Carsten Bøcker Pedersen, Marianne Giørtz Pedersen, Roseann E Peterson, Giorgio Pistis, Saira Saeed Mirza, Robert A Schoevers, Eva C. Schulte, Grant Sinnamon, Fabian Streit, Jana Strohmaier, Matthew Traylor, Vassily Vladimirovich Trubetskoy, Daniel Umbricht, Sandra Van der Auwera, Albert M van Hemert, Shantel Marie Weinsheimer, Klaus Berger, Udo Dannlowski, J Raymond DePaulo, Katharina Domschke, Caroline Hayward, Pamela A F Madden, Ole Mors, Sara A Paciga, David J. Porteous, Catherine Schaefer, Henry Völzke, Enrique Castelao, Jesper Krogh, Jonas Bybjerg-Grauholm, Sven Cichon, Michelle Agee, Babak Alipanahi, Katarzyna Bryc, Sarah L Elson, Karen E. Huber, Jennifer C McCreight, Matthew K McIntyre, Steven Pitts, Fah J. Sathirapongsasuti, Olga Sazonova, Janie F. Shelton, Vladimir Vacic, Heather C Whalley, Bernhard Baune, Erik Pettersson, Ian B Hickie, Lucía Colodro-Conde, Nese Direk, Julia Kraft, Rudolf Uher, Miruna C Barbu, Jude Gibson, Wesley K Thompson, Glyn Lewis
2018-10-01

Lost in Translation: Traversing the Complex Path from Genomics to Therapeutics in Autism Spectrum Disorder

Nenad Sestan
2018-11-23

Genome-wide association study of treatment-resistance in depression and meta-analysis of three independent samples

Chiara Fabbri, Lucie Bartova, Markus Dold, Diego Albani, Rudolf Uher, Joseph Zohar, Cathryn Lewis
2018-12-01

Comprehensive functional genomic resource and integrative model for the human brain

Daifeng Wang, Shuang Liu, Jonathan Warrell, Hyejung Won, Xu Shi, Fábio C P Navarro, Declan Clarke, Mengting Gu, Prashant Emani, Yu-Cheng Yang, Michael J. Gandal, Jonathan J Park, Suhn K Rhie, Holly Zhou, Eugenio Mattei, Dominic Fitzgerald, Jill Moore, Kiran Girdhar, Gabriel E Hoffman, Selim Kalayci, Zeynep H Gümüs, Gregory E Crawford, Panos Roussos, Andrew E Jaffe, Kevin P White, Nenad Sestan, Daniel Geschwind, James A. Knowles, Mark Bender Gerstein
2017-01-17

Natural language processing to extract symptoms of severe mental illness from clinical text: the Clinical Record Interactive Search Comprehensive Data Extraction (CRIS-CODE) project

Richard George Jackson, Rashmi Patel, Anna Kolliakou, Angus Roberts, Richard Dobson, Robert Stewart
2017-05-30

The use of electronic health records for psychiatric phenotyping and genomics

Jordan W Smoller
2017-07-01

10 Years of GWAS Discovery: Biology, Function, and Translation

Jian Yang, Qian Zhang, Mark McCarthy, Peter M. Visscher, Naomi R. Wray, Pamela Sklar
2017-07-13

No Evidence That Schizophrenia Candidate Genes Are More Associated With Schizophrenia Than Noncandidate Genes

Emma C Johnson, Richard Border, Christiaan de Leeuw
2017-08-29

Embracing polygenicity: a review of methods and tools for psychiatric genetics research

Matthew R Robinson, Naomi R. Wray
2017-09-01

Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016

Benn Sartorius, Erkin Mirrakhimov, Khurshid Alam, Sadaf G. Sepanlou, Alireza Mohammadi, Katarzyna Kissimova-Skarbek, Maysaa El Sayed Zaki, Mostafa Qorbani, Samer Hamidi, Tesfay Mehari Atey, João V. Santos, Ferrán Catalá-López, Sorin Hostiuc, Gholamreza Roshandel, Srinivasa Katikireddi, Anurag Agrawal, Yuan-pang Wang, David M. Pereira, Jung-Chen Chang, Kefyalew Addis Alene, Neil Pearce, Dina Nur Anggraini Ningrum, Alireza Esteghamati, Marcella Montico, Simon Iain Hay, Amador Goodridge, Liliana G Ciobanu, Richard C. Franklin, Jose Martinez-Raga, Yannick Béjot, Ilana Ackerman, Miriam Levi, Jonathan Carapetis, Sanjay K Mohanty, Reginald Quansah
2017-10-03

Psychiatric Genomics: An Update and an Agenda.

Sven Cichon, Cynthia Bulik, Ole A. Andreassen, Arpana Agrawal, Stephen Faraone, Jordan W Smoller, Caroline M Nievergelt, Carol A Mathews, Patrick F. Sullivan, Gerome Breen, Michael C O'Donovan, Anders D. Børglum, Howard J Edenberg, Joel Gelernter
2017-11-01

How Good Were Candidate Gene Guesses in Schizophrenia Genetics?

Patrick F Sullivan
2017-12-01

Genetic Association of Major Depression With Atypical Features and Obesity-Related Immunometabolic Dysregulations

Femke Lamers, Carol Kan, Dorret Boomsma, Cathryn Lewis, Naomi R. Wray, Brenda Penninx, Alexander Teumer, Gerome Breen, Yuri Milaneschi, Hans J Grabe, Wouter J Peyrot, Andreas J Forstner, Bernhard Baune, Martin Preisig, Fabian Streit, Sandra Van der Auwera, Marcella Rietschel
2017-09-18

Electronic health record and genome-wide genetic data in Generation Scotland participants

Shona M Kerr, Archie I Campbell, Jonathan Marten, Veronique Vitart, Andrew McIntosh, David J. Porteous, Caroline Hayward
2017-10-30

Self-reported medication use validated through record linkage to national prescribing data.

Archie I Campbell, Donald J. MacIntyre, Andrew McIntosh, Stephen M Lawrie

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