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GATOR1-dependent recruitment of FLCN-FNIP to lysosomes coordinates Rag GTPase heterodimer nucleotide status in response to amino acids.

author

Jin Meng

Shawn M Ferguson

published in: Journal of Cell Biology

date of publication: 2018-05-30

main subject: Folliculin, Folliculin interacting protein 1

Cites articles 53

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2018-03-28

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Kuang Shen, Rick Kuo-Jui Huang, Edward J Brignole, Kendall J Condon, Max L. Valenstein, Lynne Chantranupong, Aimaiti Bomaliyamu, Abigail Choe, Chuan Hong, Zhiheng Yu, David M. Sabatini
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mTOR Signaling in Growth, Metabolism, and Disease

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Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth.

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2017-07-01

Feedback Inhibition of the Rag GTPase GAP Complex Lst4-Lst7 Safeguards TORC1 from Hyperactivation by Amino Acid Signals

Jörn Dengjel, Claudio De Virgilio
2017-08-01

The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway.

David M. Sabatini
2017-09-29

FLCN: The causative gene for Birt-Hogg-Dubé syndrome
2017-10-17

Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability.

David M. Sabatini
2017-11-05

Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex

Goran Stjepanovic
2017-11-09

Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1.
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Structural basis for the assembly of the Ragulator-Rag GTPase complex

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Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA.

Jacob E Corn, Christopher D Richardson
2016-03-24

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

Steven P. Gygi, David M. Sabatini, J. Wade Harper
2016-04-13

Folliculin directs the formation of a Rab34-RILP complex to control the nutrient-dependent dynamic distribution of lysosomes

Emily R. Eden, Mark Dodding
2016-05-19

GATOR1 complex: the common genetic actor in focal epilepsies

Francesca Bisulli, Paolo Tinuper, Laura Licchetta, Tommaso Pippucci, Sara Baldassari
2016-08-24

C9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling
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An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer

Michael E. Talkowski, Ben Zhou, Steven P. Gygi
2015-03-30

Sestrin2 inhibits mTORC1 through modulation of GATOR complexes

Michael Karin
2015-10-06

Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2.

Claudio De Virgilio
2015-10-08

Sestrin2 is a leucine sensor for the mTORC1 pathway

David M. Sabatini
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Folliculin, a tumor suppressor associated with Birt-Hogg-Dubé (BHD) syndrome, is a novel modifier of TDP-43 cytoplasmic translocation and aggregation.
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Lst4, the yeast Fnip1/2 orthologue, is a DENN-family protein

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The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris
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Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome

Christian C. Dibble, Lewis C. Cantley
2014-10-09

The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1

Steven P. Gygi, Eric Spooner, David M. Sabatini
2014-11-20

Sestrins inhibit mTORC1 kinase activation through the GATOR complex

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Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery

Jennifer Doudna
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Regulation of small GTPases by GEFs, GAPs, and GDIs
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The product of C9orf72, a gene strongly implicated in neurodegeneration, is structurally related to DENN Rab-GEFs
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Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes
2013-05-28

Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1.

Claudio De Virgilio
2013-05-31

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

Matthew Meyerson, Andrew D Cherniack, Walter W Chen, David M. Sabatini
2013-09-01

Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases

Article - wd:Q64911975

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