Robert Fletterick

ocupație: cercetător

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Articole 48

Dată

Title

Autori

2019-03-07

Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite

Robert Fletterick
2018-10-10

LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival

Ophir D Klein, Holly Ingraham, Robert Fletterick
2017-04-26

NR5A2 discovering compounds that block tumor growth in PDAC

Robert Fletterick
2017-10-05

Development of 5N-Bicalutamide, a High-Affinity Reversible Covalent Antiandrogen.

Matthew P. Jacobson, Charles Truillet, Pamela M England, Robert Fletterick
2016-07-28

Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2)

Matthew P. Jacobson, Pamela M England, Holly Ingraham, Robert Fletterick
2016-01-29

Dlx5 Homeodomain:DNA Complex: Structure, Binding and Effect of Mutations Related to Split Hand and Foot Malformation Syndrome

Kurt Wüthrich, Michael Geralt, Marc André Elsliger, Ian Andrew Wilson, Ashley M Deacon, Robert Fletterick, Herbert L. Axelrod, Fumiaki Yumoto
2015-03-30

Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells

Adam Godzik, Marc C. Deller, Shinya Yamanaka, Marc André Elsliger, Ian Andrew Wilson, Ashley M Deacon, Robert Fletterick, Mitchell D Miller, Hsiu-Ching Chiu, Fumiaki Yumoto, Scott A Lesley, Thomas Clayton, Debanu Das, Carol L Farr
2015-02-09

Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs

Robert Fletterick
2015-07-24

The FKBP52 Cochaperone Acts in Synergy with β-Catenin to Potentiate Androgen Receptor Signaling

Marc B Cox, Robert Fletterick
2015-09-25

Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket

Raymond D. Blind, Ashley M Deacon, Holly Ingraham, Robert Fletterick, Debanu Das
2015-12-11

A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver

Holly Ingraham, Robert Fletterick
2015-02-17

Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism

Robert Fletterick
2014-06-24

Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D

Robert Fletterick
2014

The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable

Guillaume Poncet-Montange, Carly S Filgueira, Robert Fletterick
2014-10-06

The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1.

Raymond D. Blind, Ashley M Deacon, Holly Ingraham, Robert Fletterick, Debanu Das
2014-12-11

Advances in our structural understanding of orphan nuclear receptors

Eva Estébanez-Perpiñá, Robert Fletterick
2013-05-10

Structure-based discovery of antagonists of nuclear receptor LRH-1.

John J Irwin, Brian K. Shoichet, Jens Carlsson, Robert Fletterick
2012

Structure of a Novel Winged-Helix Like Domain from Human NFRKB Protein

Adam Godzik, Łukasz Jaroszewski, Abhinav Kumar, Marc André Elsliger, Anna Grzechnik, Ian Andrew Wilson, Heath E Klock, Ashley M Deacon, Robert Fletterick, Hsiu-Ching Chiu, Fumiaki Yumoto, Christian X Weichenberger, Carol L Farr, Scott A Lesley
2012-01-03

Structural basis of coactivation of liver receptor homolog-1 by -catenin

Robert Fletterick
2011-07-05

Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells

Marc B Cox, R. Kiplin Guy, Robert Fletterick, Len Neckers, Jane B Trepel
2011-09-26

Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation

Robert Fletterick
2009-04

Molecular basis for dimer formation of TRβ variant D355R

Robert Fletterick
2008-09-01

6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) forms an irreversible bond to the active site of the GluR2 AMPA receptor

Eva Estébanez-Perpiñá, Robert Fletterick
2008-11-06

Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands

Raymond D. Blind, Holly Ingraham, Robert Fletterick
2008-11-25

The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1

Holly Ingraham, Robert Fletterick
2007-12

Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor

Marie Togashi, Leggy A Arnold, R. Kiplin Guy, Robert Fletterick, Paul B Webb, Eva Estébanez-Perpiñá, Natalia Jouravel, Ellena Mar
2007-10-02

A surface on the androgen receptor that allosterically regulates coactivator binding

Eva Estébanez-Perpiñá, R. Kiplin Guy, Leggy A Arnold, Robert Fletterick, Paul B Webb, Ellena Mar
2007-10-17

Interaction between the androgen receptor and a segment of its corepressor SHP

Leggy A Arnold, R. Kiplin Guy, Robert Fletterick, Natalia Jouravel
2007-10-05

Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships

Leggy A Arnold, Eva Estébanez-Perpiñá, R. Kiplin Guy, Robert Fletterick, Aaron Kosinski
2007-10-01

Perspectives on designs of antiandrogens for prostate cancer

Eva Estébanez-Perpiñá, Robert Fletterick
2006-01-13

An atomic model of the thin filament in the relaxed and Ca2+-activated states

Paul Curmi, William Lehman, Robert Fletterick
2006-06-27

A high-throughput screening method to identify small molecule inhibitors of thyroid hormone receptor coactivator binding

Leggy A Arnold, Eva Estébanez-Perpiñá, Cory A Ocasio, R. Kiplin Guy, Anang A. Shelat, Marie Togashi, Robert Fletterick, Andrea C McReynolds, Paul B Webb

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