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CD8+ T cell states in human cancer: insights from single-cell analysis

author

Anne M van der Leun

Daniela S Thommen

Ton Schumacher

1965 -

published in: Nature Reviews Cancer

date of publication: 2020-02-05

Cites articles 92

Date

Title

Authors

2019-10-23

MHC-II neoantigens shape tumour immunity and response to immunotherapy

Elise Alspach, Maxim N Artyomov, Tyler Jacks
2019-07-29

Clonal replacement of tumor-specific T cells following PD-1 blockade

Kathryn E Yost, Ansuman T Satpathy, Kavita Y Sarin, Christina Curtis, Mark Davis, Anne Lynn S. Chang, Howard Y. Chang
2019-06-21

Single-cell transcriptomic analysis of tissue-resident memory T cells in human lung cancer

Christopher J Hanley, Grégory Seumois, Tilman Sanchez-Elsner, Ferhat Ay, Christian H. Ottensmeier, Pandurangan Vijayanand
2019-04-11

A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer

Simone Muenst, Jonas Windhager, Karīna Siliņa, María Rodríguez Martínez, Bernd Bodenmiller
2019-06-01

Tertiary lymphoid structures in the era of cancer immunotherapy

Catherine Sautès-Fridman, Florent Petitprez, Wolf Hervé Fridman
2019-02-18

Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

Brian C Miller, Debattama R Sen, Rose Al Abosy, Martin W LaFleur, Jenna Collier, W Nicholas Haining, F Stephen Hodi
2019-02-04

Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy

Christopher A Pennell, David Masopust, Bruce R Blazar
2019-01-08

Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy

Imran Siddiqui, Santiago J. Carmona, Sanjiv A Luther
2019-01-08

Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1-CD8+ Tumor-Infiltrating T Cells

Giulia Escobar, Max Klapholz, Aviv Regev, Orit Rozenblatt-Rosen, Danielle Dionne
2019-09-16

PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity

Thao H Nguyen, Brian C Miller, Kathleen B Yates, Rose Al Abosy, W Nicholas Haining, Arlene Sharpe, Gordon J. Freeman
2019-03-26

Negative Co-stimulation Constrains T Cell Differentiation by Imposing Boundaries on Possible Cell States

James J. Mancuso, Dana Pe'er, Manu Setty
2019-02-01

Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy

Camelia Quek, Jeff Holst, Su Yin Lim, Angel Pang, Helen Rizos, Richard Scolyer, Georgina V. Long, Alexander M Menzies
2019-11-01

Differences in Tumor Microenvironment Dictate T Helper Lineage Polarization and Response to Immune Checkpoint Therapy
2019-05-01

T Follicular Helper Cell Biology: A Decade of Discovery and Diseases

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2019-06-17

TOX is a critical regulator of tumour-specific T cell differentiation

Smita S Chandran, Laura Menocal, Matthew R Femia, Niroshana Anandasabapathy
2019-06-17

TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection

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2019-06-17

TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

Sierra McDonald, Giorgos Karakousis
2019-09-30

Defining 'T cell exhaustion'

Christian U Blank, Werner Held, Patrick Hogan, Axel Kallies, Enrico Lugli, Rachel C Lynn, Mary Philip, Andrea Schietinger, Ton Schumacher, Pamela L. Schwartzberg, Arlene Sharpe, Daniel E Speiser, E. John Wherry, Ben Youngblood, Dietmar Zehn, Anjana Rao, W Nicholas Haining
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Comprehensive Integration of Single-Cell Data

Tim Stuart, Rahul Satija, Christoph Hafemeister, William M. Mauck III, Andrew Butler, Paul J Hoffman, Marlon Stoeckius, Peter Smibert, Efthymia Papalexi
2019-06-06

Single-Cell Multi-omic Integration Compares and Contrasts Features of Brain Cell Identity

Caroline A Martin, Evan Z Macosko, Charles R Vanderburg, Joshua D Welch, Velina Kozareva
2019-06-08

Heterogeneity and fate choice: T cell exhaustion in cancer and chronic infections
2018-12-27

Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma

Alexander C.J. van Akkooi, Ton Schumacher, Amir Giladi, Amos Tanay, Eyal David, Elisa A Rozeman, Christian U Blank
2018-11-01

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

Carl G de Boer, Samuel S Freeman, Vancheswaran Gopalakrishnan, Sangeetha Reddy, Zachary A. Cooper, Alexandra-Chloé Villani, Nir Hacohen, Patrick H Lizotte, David A Barbie, Russell William Jenkins, Moshe Sade-Feldman, David J Lieb, Michal Barzily-Rokni, Alexandre Reuben, Bo Li, Jennifer Wargo, Ryan J Sullivan, Keith Flaherty, Gad Getz, Anat Stemmer-Rachamimov
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A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

Daniela S Thommen, Viktor H. Koelzer, Marcel Philipp Trefny, Sarah Dimeloe, Ping-Chih Ho, Christian Klein, Ton Schumacher
2018-06-25

Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing

Boxi Kang, Xianwen Ren, Zhang Zemin
2018-10-29

Lineage tracking reveals dynamic relationships of T cells in colorectal cancer

Boxi Kang
2018-06-28

Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment

Linas Mazutis, Vaidotas Kiseliovas, Dana Pe'er, Manu Setty
2018-06-25

Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis

Peter Savas, Chengzhong Ye, Agus Salim, Stephen Fox, Laura K. Mackay, Sherene Loi, Terry Speed
2018-10-22

Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells

Fiamma Salerno, Aurelie Guislain, Julian J Freen-van Heeren, Benoit P Nicolet, Howard A Young, Monika C Wolkers
2018-06-26

Immune Cell Dynamics Unfolded by Single-Cell Technologies

Daniel J Kunz, Tomás Gomes
2018-12-03

Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers

Petur Snaebjornsson, John B A G Haanen, Ton Schumacher, Katy Milne
2018-05-16

Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates

Si-Lin Koo, Joe Yeong, Zhang, Tong, Michael Poidinger, Evan W Newell, Etienne Becht

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