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Translation of HDAC6 PET Imaging Using [18F]EKZ-001-cGMP Production and Measurement of HDAC6 Target Occupancy in Nonhuman Primates

forfatter

Sofie Celen

Tonya M Gilbert

Frederick A Schroeder

Tom Bleeser

M Hassan Beyzavi

Janice E Kranz

Jacob M. Hooker

Christopher Cawthorne

Guy Bormans

Kim Serdons

Florence F Wagner

Baileigh G Hightower

udgivet i: ACS Chemical Neuroscience

dato for udgivelse: 2020-03-19

Cites articles 30

Date

Titel

Forfattere

2019-05-29

Evaluation of [11C]KB631 as a PET tracer for in vivo visualisation of HDAC6 in B16.F10 melanoma

Guy Bormans
2018-05-29

The novel histone de acetylase 6 inhibitor, MPT0G211, ameliorates tau phosphorylation and cognitive deficits in an Alzheimer's disease model.

Chia-Ron Yang
2018-12

A Variant Identified in a Sporadic Amyotrophic Lateral Sclerosis Patient Impairs Microtubule Stability and Axonal Mitochondria Distribution
2017-02-28

Increased acetylation of Peroxiredoxin1 by HDAC6 inhibition leads to recovery of Aβ-induced impaired axonal transport

Inhee Mook-Jung
2017-04-28

A population MRI brain template and analysis tools for the macaque

Leslie G. Ungerleider
2017-07-31

An acetylation-phosphorylation switch that regulates tau aggregation propensity and function

Leonard Petrucelli
2017-08-17

Inhibition of HDAC6 increases acetylation of peroxiredoxin1/2 and ameliorates 6-OHDA induced dopaminergic injury.
2017-08-03

18F-Deoxyfluorination of Phenols via Ru π-Complexes

Constanze N Neumann, Junting Chen, Jacob M. Hooker
2017-09-06

HDAC6 Brain Mapping with [18F]Bavarostat Enabled by a Ru-Mediated Deoxyfluorination

Thomas M Morin
2017-10-11

HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients

Catherine Verfaillie, Wenting Guo, Tijs Vandoorne, Ruben Boon, L Ordovas, Abdulsamie Patel, Tine Tricot, Werend Boesmans, Jared Sterneckert, Pieter Vanden Berghe, Philip Van Damme, Ludo Van Den Bosch
2015-12-08

Exploration of the labeling of [11C]tubastatin A at the hydroxamic acid site with [11C]carbon monoxide

Shuiyu Lu, Jay H. Kalin
2014-02-27

Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition

Jay H. Kalin
2014-01-01

Tubastatin A/ACY-1215 improves cognition in Alzheimer's disease transgenic mice
2014-09-18

In vivo imaging of histone deacetylases (HDACs) in the central nervous system and major peripheral organs

Ronald Borra, Jacob M. Hooker
2014-10-15

Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations

Kurt J De Vos, Christopher C. Miller, Alexander J. Whitworth
2014-08-28

Enhancement of stress resilience through histone deacetylase 6-mediated regulation of glucocorticoid receptor chaperone dynamics

Olivier Berton
2013-08-19

Antidepressant-like properties of novel HDAC6-selective inhibitors with improved brain bioavailability

Ralph Mazitschek, Olivier Berton
2013-08-19

Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance

Dennis W. Dickson, Leonard Petrucelli
2012-03-01

HDAC6 regulates glucocorticoid receptor signaling in serotonin pathways with critical impact on stress resilience

Olivier Berton
2012-10-11

Mercaptoacetamide-based class II HDAC inhibitor lowers Aβ levels and improves learning and memory in a mouse model of Alzheimer's disease

Amanda Marie DiBattista, Raymond Turner, Jungsu Kim
2010-01-14

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

Joo-Yong Lee, Esther Wong, Jianrong Lu, J Paul Taylor, Ana Maria Cuervo
2009-09-09

Measuring drug occupancy in the absence of a reference region: the Lassen plot re-visited

Roger N. Gunn, Eugenii A. Rabiner, Vincent J. Cunningham, Marc A Laruelle, Mark Slifstein
2008-11-07

The presence of ethanol in radiopharmaceutical injections

Guy Bormans
2008-11-14

A population-average MRI-based atlas collection of the rhesus macaque

Sterling C. Johnson
2007-03-01

Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation

Juliette D Godin, Fabrice P Cordelières, Sandrine Humbert, Frédéric Saudou
2005-05-27

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor

June-Tai Wu, Minoru Yoshida
2005-08-08

Regulation of the dynamics of hsp90 action on the glucocorticoid receptor by acetylation/deacetylation of the chaperone
2003-04-03

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

Stephen J Haggarty, Christina M. Grozinger, Stuart Schreiber
2002-05-23

HDAC6 is a microtubule-associated deacetylase

Minoru Yoshida
2000-04-01

Some factors affecting metal ion-monohydroxamate interactions in aqueous solution

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