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PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

published in: Nature

date of publication: 2019-01-30

language: English

main subject: cardiac stress

Cites articles 29

Date

Title

Authors

2018-02-01

New Insights Into the Role of mTOR Signaling in the Cardiovascular System
2017-03-01

mTOR Signaling in Growth, Metabolism, and Disease

David M. Sabatini
2016-10-28

Cardiac Phosphodiesterases and Their Modulation for Treating Heart Disease
2016-05-25

Proteogenomics connects somatic mutations to signalling in breast cancer

Venkata Yellapantula, Emily Kawaler, Jonathan T. Lei, Sherri R Davies, Kelly V. Ruggles, Charles M. Perou, Christopher R Kinsinger
2016-03-29

mTOR Hyperactivation by Ablation of Tuberous Sclerosis Complex 2 in the Mouse Heart Induces Cardiac Dysfunction with the Increased Number of Small Mitochondria Mediated through the Down-Regulation of Autophagy

Ajay M. Shah
2016-10-26

Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response

Kornel Kistamas, Olena Rudyk, Pedro R Cutillas, Michael S. Marber, Maria R. Conte, Philip Eaton
2015-03-26

Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease

Peter P Rainer, Jonathan A. Kirk
2015-05-04

Prevention of PKG1α oxidation augments cardioprotection in the stressed heart

Philip Eaton
2014-07-13

Coordinated regulation of protein synthesis and degradation by mTORC1

Justin Nicholatos, Scott B Widenmaier, Gökhan Hotamışlıgil
2014-02-13

Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome

Christian C. Dibble, Lewis C. Cantley
2014-08-08

Expansion of the CRISPR-Cas9 genome targeting space through the use of H1 promoter-expressed guide RNAs

Donald J. Zack
2013-11

Genome engineering using the CRISPR-Cas9 system

Patrick D Hsu
2012-08-31

Cyclic GMP-dependent stimulation of serotonin transport does not involve direct transporter phosphorylation by cGMP-dependent protein kinase

Grace R Jeschke
2011-02-01

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Mondira Kundu, Benoit Viollet
2011-01-27

Oxidative stress stimulates autophagic flux during ischemia/reperfusion
2011-02-28

Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice.

Jaya Krishnan, Corinne Berthonneche
2011-06-09

Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90(RSK) in the control of mTORC1 protein signaling by phorbol esters

Christopher G. Proud
2010-05-06

Inhibition of TRPC6 channel activity contributes to the antihypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heart

Motohiro Nishida
2010-07-19

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.

Nahum Sonenberg, Marcello Ceci, Daniele Catalucci, Gianluigi Condorelli
2007-05-07

A semisynthetic epitope for kinase substrates

Robert O Messing
2007-10-04

Regulation of mTOR and S6K1 activation by the nPKC isoforms, PKCepsilon and PKCdelta, in adult cardiac muscle cells
2006-09-08

TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

Bart O Williams, Ormond Macdougald
2005-04-22

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

Hediye Erdjument-Bromage, Paul Tempst, Pier Paolo Pandolfi, Li Ma
2005-01-23

Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy.

Yibin Wang
2005-01-12

Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors

Scott A. Gerber, Philippe P. Roux, Jeffrey P MacKeigan, Steven P. Gygi
2004-09-01

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

Philippe P. Roux, Steven P. Gygi
2003-11-26

TSC2 mediates cellular energy response to control cell growth and survival
2003-10-01

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR
2002-09-01

Akt regulates growth by directly phosphorylating Tsc2

Christopher J. Potter

Article - wd:Q91284093

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