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High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus

author

Sarah Reid

David L Morris

Elisabet Svenungsson

1955 -

Sabine Arve

Solbritt Rantapää Dahlqvist

1947 -

Christopher Sjöwall

Lars Rönnblom

Dag Leonard

Ann-Christine Syvänen

1950 -

published in: Annals of the Rheumatic Diseases

date of publication: 2019-12-11

main subject: systemic lupus erythematosus

Cites articles 46

Date

Title

Authors

2020-01-01

Association of systemic lupus erythematosus (SLE) genetic susceptibility loci with lupus nephritis in childhood-onset and adult-onset SLE

Andrew D. Paterson, Murray B Urowitz, Joan Wither, Dafna D. Gladman
2019-08-13

Interferon pathway in SLE: one key to unlocking the mystery of the disease

Lars Rönnblom
2019-07-11

The majority of Swedish systemic lupus erythematosus patients are still affected by irreversible organ impairment: factors related to damage accrual in two regional cohorts

Martina Frodlund, Jonas Wetterö, Christopher Sjöwall
2018-04-18

A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus

Jennifer A Kelly, Juan-Manuel Anaya, Marta E Alarcón-Riquelme, Joel M Guthridge, Sang-Cheol Bae, Timothy Vyse, John D Reveille, Michelle A. Petri, John B. Harley, Judith A. James, Carl D. Langefeld, Barry Freedman, Gary S. Gilkeson, Lindsey A. Criswell, Patrick M Gaffney, Mary E Comeau, Betty P. Tsao, Julie T Ziegler, Graciela S Alarcón, Joan T Merrill, Diane Kamen, Rosalind Ramsey-Goldman, Miranda C. Marion, Susan A. Boackle, Robert P. Kimberly, Leah C. Kottyan, Timothy B. Niewold, Jeffrey C Edberg, Robert Hal Scofield, Bahram Namjou, Bernardo Antonio Pons-Estel, Deborah S Cunninghame Graham, Erin E Zoller, Matthew T Weirauch, Swapan K Nath, Zubin H Patel, Albert F Magnusen, Kathy L Sivils, Hye-Soon Lee, Hermine I Brunner, Jennifer L Huggins, Michael H Weisman, Earl D Silverman
2018

STAT4 gene polymorphism in two major autoimmune diseases (multiple sclerosis and juvenile onset systemic lupus erythematosus) and its relation to disease severity
2018-02-23

The STAT4 SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE.

Ann-Christine Syvänen
2017-12-04

Recent developments in systemic lupus erythematosus pathogenesis and applications for therapy.
2017-07-17

Transancestral mapping and genetic load in systemic lupus erythematosus

Ann-Christine Syvänen, Tushar Bhangale, Jennifer A Croker, Johanna Sandling, Jorge A Esquivel-Valerio, Christopher Sjöwall, Leah C. Kottyan, Joan Wither, Joel M Guthridge, Jennifer A Kelly, Marta E Alarcón-Riquelme, Norberto Ortego-Centeno, John D. Rioux, Elisabet Svenungsson, Javier Martin, Dafna D. Gladman, Helle Laustrup, Vicente Baca, Janet Pope, Andrea Doria, Carlos Vasconcelos, Ricard Cervera i Segura, Timothy Vyse, John D Reveille, Michelle A. Petri, John B. Harley, Judith A. James, Solbritt Rantapää Dahlqvist, Cees G M Kallenberg, Peter K. Gregersen, Carl D. Langefeld, Barry Freedman, Gary S. Gilkeson, Lindsey A. Criswell, Patrick M Gaffney, Mary E Comeau, Michael F Seldin, Jorge R. Oksenberg, Lorena Orozco, Betty P. Tsao, Graciela S Alarcón, Joan T Merrill, Diane Kamen, Rosalind Ramsey-Goldman, Miranda C. Marion, Robert P. Kimberly, Timothy B. Niewold, David McWilliams, Jeffrey C Edberg, Carlos Alberto Aguilar Salinas, Bernardo Antonio Pons-Estel, Deborah S Cunninghame Graham, Swapan K Nath, Kathy L Sivils, Hermine I Brunner, Jennifer L Huggins, Michael H Weisman, Earl D Silverman, Raffaella Scorza, Mario Humberto Cardiel, Berta Martins Silva, Johan Frostegard, Iva Gunnarsson, Bernard R Lauwerys, Marco A Maradiaga-Ceceña, Lennart Truedsson, Lars Rönnblom, Jonas Carlsson Almlöf, José Mario Sabio, Joseph M McCune, Paul R Fortin, David R Karp, Christian A Pineau, Paula S Ramos, David L Morris, Sandra D'alfonso, Susan D Thompson
2017-09-01

Genetic advances in systemic lupus erythematosus: an update

Lingyan Chen, David L Morris
2016-11-07

Update on Lupus Nephritis

Brad H Rovin
2016-09-28

Genetics of human lupus nephritis.
2016-09-24

The role of autophagy in the pathogenesis of systemic lupus erythematosus
2016-07-28

Genetic risk and longitudinal disease activity in systemic lupus erythematosus using targeted maximum likelihood estimation

Milena A. Gianfrancesco, Lindsey A. Criswell, Michael F Seldin, Lisa F Barcellos
2016-07-11

Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus

Nathalie Costedoat-Chalumeau, Amy L Roberts, Timothy Vyse, Georg Schett, Patrick M Gaffney
2016

A comparison of genetic risk score with family history for estimating prostate cancer risk
2016-03-15

Presence of Antiphospholipid Antibodies as a Risk Factor for Thrombotic Events in Patients with Connective Tissue Diseases and Idiopathic Thrombocytopenic Purpura
2016-03-15

Clinical features and long-term outcomes of systemic lupus erythematosus: comparative data of childhood, adult and late-onset disease in a national register

Luís Sousa Inês, Diogo Jesus, José Antonio da Silva, Helena Canhão, Maria J. Santos
2016-06-01

Risk of End-Stage Renal Disease in Patients With Lupus Nephritis, 1971-2015: A Systematic Review and Bayesian Meta-Analysis

Maria G Tektonidou, Abhijit Dasgupta
2015-12-21

Genetic Factors in Systemic Lupus Erythematosus: Contribution to Disease Phenotype

Carlo Perricone, Cinzia Ciccacci, Cristiano Alessandri, Antonio Sili Scavalli, G Valesini
2015-10-22

The Role of Autophagy in Lupus Nephritis
2015-10-26

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus

Marta E Alarcón-Riquelme, James Bentham, David L Morris, Christopher L Pinder, Javier Martin, Benjamin P Fairfax, Julian C Knight, Lingyan Chen, Joseph M Replogle, Joan Wither, John D. Rioux, Ann-Christine Syvänen
2015-03-16

A genetic risk score of 45 coronary artery disease risk variants associates with increased risk of myocardial infarction in 6041 Danish individuals

Johanne Marie Justesen, Niels Grarup, Torben Jørgensen, Kristine H Allin
2015-09

Factors associated with damage accrual in patients with systemic lupus erythematosus: results from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort

Ronald van Vollenhoven, Ian Bruce, Manuel Ramos-casals, Sang-Cheol Bae, Guillermo Ruiz-Irastorza, David A. Isenberg, Caroline Gordon, Dafna D. Gladman, Munther A. Khamashta, Michelle A. Petri, Graciela S Alarcón, Joan T Merrill, Diane Kamen, Cynthia Aranow, Susan Manzi, Sasha Bernatsky, Rosalind Ramsey-Goldman, Kenneth C. Kalunian, Ellen M Ginzler, Mary Anne Dooley, Christine A Peschken, Meggan Mackay, John G Hanly, Ann E Clarke, Paul R Fortin, Murray B Urowitz, Juanita Romero-Diaz, Jorge Sánchez-Guerrero, Asad A Zoma, Ola Nived, Aidan G O'Keeffe, Barri J Fessler, Kristjan Steinsson, Gunnar Sturfelt, Sung Lim
2014-06-19

Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus

Maria J. Santos, Patricia E Carreira, Gian Domenico Sebastiani, Antonio Gonzalez
2013-12-27

Association of STAT4 polymorphism with severe renal insufficiency in lupus nephritis

Ann-Christine Syvänen, Johanna Sandling, Christopher Sjöwall, Elisabet Svenungsson, Maija-Leena Eloranta, Andreas Jönsen, Iva Gunnarsson, Gunnel Nordmark, Lars Rönnblom, Agneta Zickert
2013-01-01

Development and evaluation of a genetic risk score for obesity

Daniel W Belsky, Avshalom Caspi, Terrie Moffitt, Renate Houts, Karen Sugden
2013-03-21

Late-onset systemic lupus erythematosus: clinical features, course, and prognosis
2012-12-01

Predictors of organ damage in systemic lupus erythematosus: the Hopkins Lupus Cohort

Michelle A. Petri
2012-08-14

HLA-DRB1*04/*13 alleles are associated with vascular disease and antiphospholipid antibodies in systemic lupus erythematosus.

Lars Klareskog, Leonid Padyukov, Elisabet Svenungsson, Johanna Sandling, Ann-Christine Syvänen, Ulf Sundin, Emeli Lundström, Lars Rönnblom, Iva Gunnarsson, Andreas Jönsen, Dag Leonard, Gunnel Nordmark, Gunnar Sturfelt, Kerstin Elvin, Agneta Zickert
2012-01-01

Risk factors for cardiovascular mortality in patients with systemic lupus erythematosus, a prospective cohort study

Julia Simard, Ingrid E Lundberg, Elisabet Svenungsson, Anders Larsson
2011-11-21

Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus

Elena Sanchez, Jennifer A Kelly, Timothy B. Niewold, Robert P. Kimberly, Marta E Alarcón-Riquelme, Javier Martin, Timothy Vyse, John D Reveille, Michelle A. Petri, John B. Harley, Judith A. James, Carl D. Langefeld, Gary S. Gilkeson, Lindsey A. Criswell, Patrick M Gaffney, Betty P. Tsao, Graciela S Alarcón, Joan T Merrill, Rosalind Ramsey-Goldman, Susan A. Boackle, Jeffrey C Edberg, Amr H Sawalha, Travis S Hughes, Robert Hal Scofield
2011-02-17

Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes

Marta E Alarcón-Riquelme, Michelle A. Petri, John B. Harley, Peter K. Gregersen, Carl D. Langefeld, Lindsey A. Criswell, Patrick M Gaffney, Betty P. Tsao, Susan Manzi

Article - wd:Q91887909

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