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Mutations in spliceosome genes and therapeutic opportunities in myeloid malignancies

author

Justin Taylor

Stanley C Lee

published in: Genes, Chromosomes and Cancer

date of publication: 2019-09-03

Cites articles 151

Date

Title

Authors

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Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss
2019-02-01

PRMT5 Modulates Splicing for Genome Integrity and Preserves Proteostasis of Hematopoietic Stem Cells
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Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia

Jochen Imig, Akihide Yoshimi, Iannis Aifantis
2018-11-06

Modeling human RNA spliceosome mutations in the mouse: not all mice were created equal

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2018-10-15

Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene U2af1

Dennis Liang Fei, Benjamin Durham, Tuo Zhang, Akihide Yoshimi, Robert K. Bradley, Omar Abdel-Wahab
2018-09-07

Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia

Tetsuichi Yoshizato, Hideki Makishima, Kenichi Chiba, Yuichi Shiraishi, Seishi Ogawa, Aiko Sato-Otsubo, Keisuke Kataoka, Yosaku Watatani, Masashi Sanada
2018-09-01

PRMT5 Regulates DNA Repair by Controlling the Alternative Splicing of Histone-Modifying Enzymes

Pierre-Jacques Hamard
2018-08-01

Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations

Sydney S Lu, Bo Liu, Akihide Yoshimi, Benjamin Durham, Robert K. Bradley, Daichi Inoue, Young Rock Chung, Omar Abdel-Wahab, Stanley Chun-Wei Lee, Xiao-Jing Zhang, James Palacino, Silvia Buonamici
2018-07-27

Spliceosome Mutations Induce R Loop-Associated Sensitivity to ATR Inhibition in Myelodysplastic Syndromes

Pavankumar N.G. Reddy, Timothy A. Graubert
2018-07-09

Somatic mutations precede acute myeloid leukemia years before diagnosis

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Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations

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Srsf2P95H initiates myeloid bias and myelodysplastic/myeloproliferative syndrome from hemopoietic stem cells

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Protein Arginine Methyltransferase 5 (PRMT5) as an Anticancer Target and Its Inhibitor Discovery

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H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers

Akihide Yoshimi, Justin Taylor, Teng Teng
2018-01-27

The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations

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Physiological Srsf2 P95H expression causes impaired hematopoietic stem cell functions and aberrant RNA splicing in mice

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Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.

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LNA/DNA mixmer-based antisense oligonucleotides correct alternative splicing of the SMN2 gene and restore SMN protein expression in type 1 SMA fibroblasts

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Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex

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Structure of a pre-catalytic spliceosome

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The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes

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2017-03-16

Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15

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