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Blood-based systems biology biomarkers for next-generation clinical trials in Alzheimer's disease

author

Andrea Vergallo

Steven J Kiddle

Janet Woodcock

1948 -

published in: Dialogues in Clinical Neuroscience

date of publication: 2019-01-01

main subject: biomarker, Alzheimer's disease

Cites articles 112

Date

Title

Authors

2019

Biomarker-Drug and Liquid Biopsy Co-development for Disease Staging and Targeted Therapy: Cornerstones for Alzheimer's Precision Medicine and Pharmacology

Edward J Goetzl
2019-01-01

The Alzheimer Precision Medicine Initiative

Harald Hampel, George Perry, Andrea Vergallo, Alzheimer Precision Medicine Initiative (APMI)
2019-01-21

Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease

Christian Barro, Peter R Schofield, Martin Rossor, Bernardino F. Ghetti, James M Noble, Alison Goate, Tammie L. Benzinger, Brian A Gordon, Mathias Jucker, Anne M Fagan, John C. Morris, Randall J. Bateman, Neill R Graff-Radford, Colin L. Masters, Stephanie A Schultz, Eric McDade, John M Ringman, Dominantly Inherited Alzheimer Network Trials Unit, Stephen Salloway, Johannes Levin, Jasmeer Chhatwal, Guoqiao Wang, Oliver Preische, Jens Kuhle, Susanne Graeber, Christoph Laske, Jonathan Vöglein
2019-09-01

DIABLO: an integrative approach for identifying key molecular drivers from multi-omics assays

Florian Rohart, Casey P. Shannon
2019-02-01

A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease

Francesco Panza, Madia Lozupone, Bruno Imbimbo
2019-01-21

The impact of amyloid-beta and tau on prospective cognitive decline in older individuals

Bernard J Hanseeuw, Rachel F Buckley, Heidi Jacobs, Rebecca Betensky, Rebecca E. Amariglio
2018-12

Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci

Knut Engedal, Ingvild Saltvedt, Andreas Engvig, Dag Aarsland, Srdjan Djurovic, Ole A. Andreassen, Hreinn Stefansson, Anders M. Dale, Geir Selbæk, Kári Stefánsson, Geir Bråthen, Tormod Fladby, Ina S Almdahl, Rahul S Desikan, Stacy Steinberg, Arvid Rongve, Jon Snaedal, Ingun D. Ulstein, Sigrid B Sando, Anne Brækhus, Lavinia Athanasiu, Fred Andersen, Eystein Stordal, Shahram Bahrami, Aree Witoelar
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A two-step immunoassay for the simultaneous assessment of Aβ38, Aβ40 and Aβ42 in human blood plasma supports the Aβ42/Aβ40 ratio as a promising biomarker candidate of Alzheimer's disease

Oliver Wirths, Jens Wiltfang
2018-12-01

Current state of Alzheimer's fluid biomarkers

Philip Scheltens, Michelle M Mielke, Harald Hampel, Henrik Zetterberg, Kaj Blennow, Anne M Fagan, Jeffrey L. Cummings, John Q. Trojanowski
2018-12

Regulatory and Health Technology Assessment Considerations for Disease-Modifying Drugs in Alzheimer's Disease

Jacoline Bouvy, Pall F Jonsson
2018

A Brief Synopsis on the Genetics of Alzheimer's Disease
2018-11-09

Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease.

Henrik Zetterberg, Dennis J. Selkoe, Robert A Rissman
2018-10-11

Extracellular vesicles, new actors in the search for biomarkers of dementias
2018-11-01

Blood-based biomarkers for Alzheimer disease: mapping the road to the clinic

Colin L. Masters, Kaj Blennow, Henrik Zetterberg, Steven J Kiddle, José Luis Molinuevo, Sid O'Bryant, Richard Batrla, Harald Hampel
2018-09-29

Alzheimer's disease (AD) therapeutics - 1: Repeated clinical failures continue to question the amyloid hypothesis of AD and the current understanding of AD causality
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Plasma Amyloid as Prescreener for the Earliest Alzheimer Pathological Changes

Inge Mw Verberk, Sander C J Verfaillie, Philip Scheltens, Wiesje van der Flier, Niels D Prins, Charlotte Teunissen, Bart N M van Berckel, Rosalinde E R Slot, Hans Heijst
2018-07-20

Alzheimer's disease and blood-based biomarkers - potential contexts of use

Martina Zvěřová
2018-01-01

Editorial: Turning Point towards Blood Biomarker-Guided Targeted Therapy for Precision Medicine in Alzheimer's disease
2018-01-01

Editorial: Plasma Biomarker for Alzheimer's Disease: Are We Ready Now for Clinical Practice and Drug Trials?
2018-06-21

The National Institute on Aging-Alzheimer's Association Framework on Alzheimer's disease: Application to clinical trials
2018-04-24

The Role of Genetics in Advancing Precision Medicine for Alzheimer's Disease-A Narrative Review

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Accelerating Alzheimer's disease drug innovations from the research pipeline to patients.

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NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease.

Philip Scheltens, Reisa Sperling, David M. Holtzman, Kaj Blennow, William J. Jagust, Maria C Carrillo, Clifford Jack, Jason Karlawish, Katherine P Rankin, Frank Jessen, Christopher C Rowe, Thomas J Montine, Creighton H Phelps, Heather M Snyder, Eric R Siemers
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Plasma phospho-tau181 increases with Alzheimer's disease clinical severity and is associated with tau- and amyloid-positron emission tomography

Michelle M Mielke, David S Knopman, Ronald C. Petersen, Val J. Lowe, Mary M Machulda, Prashanthi Vemuri, Rosebud O Roberts, Clifford Jack, Jeffrey L Dage, Clinton E Hagen
2018-01-01

A Blood Test for Alzheimer's Disease: Progress, Challenges, and Recommendations.

Steven J Kiddle, Richard Dobson, Nicola Voyle
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Understanding Alzheimer Disease at the Interface between Genetics and Transcriptomics

Jan Verheijen
2018-01-01

Revolution of Alzheimer Precision Neurology Passageway of Systems Biology and Neurophysiology.

Nicola Toschi, Claudio Babiloni, Filippo Baldacci, Arun L W Bokde, Francesco Cacciola, Andrea Duggento, Maya Koronyo-Hamaoui, Christian Neri, Andrea Vergallo, Nicolas Villain, Enrica Cavedo, Olaf Sporns, Olivier Colliot, George Perry, Robert Nistico, Marie-Odile Habert
2018-01-01

Systems Biology Methods for Alzheimer's Disease Research Toward Molecular Signatures, Subtypes, and Stages and Precision Medicine: Application in Cohort Studies and Trials.

Harald Hampel, Craig W Ritchie
2018-03-01

Cerebrospinal fluid biomarkers measured by Elecsys assays compared to amyloid imaging.

Suzanne E Schindler, David M. Holtzman, Anne M Fagan, Tammie L. Benzinger, John C. Morris, Brian A Gordon
2018-02-27

CSF biomarkers of Alzheimer's disease concord with amyloid-β PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER and ADNI cohorts.

Oskar Hansson, Alzheimer's Disease Neuroimaging Initiative, Henrik Zetterberg, Kaj Blennow, John Q. Trojanowski, Erik Stomrud
2018-02-16

Precision pharmacology for Alzheimer's disease.

Andrea Vergallo, A Claudio Cuello, George Perry, Filippo Baldacci, Janet Woodcock, Alzheimer Precision Medicine Initiative (APMI)
2018-01-31

High performance plasma amyloid-β biomarkers for Alzheimer's disease.

Taisuke Tomita, Colin L. Masters, Koichi Tanaka

Article - wd:Q95579827

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